The Omega-3 Fatty Acid Docosahexaenoic Acid Attenuates Organic Dust-Induced Airway Inflammation

Nordgren, Tara M.; Friemel, Taylor; Heires, Art J.; Poole, Jill; Wyatt, Todd A.; Romberger, Debra J.

doi:10.3390/nu6125434

Cited by 34 publications

(36 citation statements)

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confidence: 66%

“…Similar beneficial results have been observed in adult animals in acute lung injury models (8,11,20,47). Other pulmonary disease models where benefits were seen with DHA or its downstream metabolites include cystic fibrosis, asthma, and pulmonary fibrosis (29,31,51).In a recent issue of the journal, Ali and colleagues (1) elegantly show that apoptosis persists in the lungs of 8-wk-old mice who had been exposed to perinatal inflammation (maternal systemic inflammation) and postnatal hyperoxia [up to postnatal day (PND) 14] followed by return of the animals to room air. This was accompanied by upregulation of some of the proteins associated with the apoptotic pathways.…”

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confidence: 64%

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Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury?

Lingappan

Moorthy

2015

American Journal of Physiology-Lung Cellular and Molecular Phys

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Lingappan K, Moorthy B. Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury?. Am J Physiol Lung Cell Mol Physiol 309: L1383-L1386, 2015. First published September 11, 2015 doi:10.1152/ajplung.00313.2015The effect of adverse perinatal environment (like maternal infection) has long-standing effects on many organ systems, including the respiratory system. Use of maternal nutritional supplements is an exciting therapeutic option that could be used to protect the developing fetus. In a recent issue of the journal, Ali and associates (Ali M, Heyob KM, Velten M, Tipple TE, Rogers LK. Am J Physiol Lung Cell Mol Physiol 309: L441-L448, 2015) specifically look at maternal docosahexaenoic acid (DHA) supplementation and its effect on chronic apoptosis in the lung in a mouse model of perinatal inflammation and postnatal hyperoxia. Strikingly, the authors show that pulmonary apoptosis was augmented even 8 wk after the hyperoxiaexposed mice had been returned to room air. This effect was significantly attenuated in mice that were subjected to maternal dietary DHA supplementation. These findings are novel, significantly advance our understanding of chronic effects of adverse perinatal and neonatal events on the developing lung, and thereby offer novel therapeutic options in the form of maternal dietary supplementation with DHA. This editorial reviews the long-term effects of adverse perinatal environment on postnatal lung development and the protective effects of dietary supplements such as DHA. docosahexaenoic acid; hyperoxia MATERNAL INFLAMMATION DURING pregnancy can occur by intraor extrauterine processes. Maternal infections both systemic (urinary tract infection, periodontitis) and chorioamnionitis have been associated with premature birth (17,27,36,49). Chorioamnionitis leads to fetal lung inflammation in animal models (18,28). The clinical correlation between chorioamnionitis and development of bronchopulmonary dysplasia (BPD) is not strong, with evidence being available both for and against the association (19,41). In animal models, chorioamnionitis induces lung maturation (increase in surfactant proteins) but also causes delayed alveolarization and vascular injury (15, 18). Intra-amniotic lipopolysaccharide (LPS) on embryonic day 15 increases alveolar type II cell number through Toll-like receptor-4 signaling (33). Maternal inflammation can potentially initiate the inflammatory cascade in the fetal lung, which can be further potentiated by postnatal exposures such as hyperoxia (45). Antenatal corticosteroids (maternal ␤-methasone) given to pregnant ewes decrease intrauterine inflammation-induced TGF-␤ signaling in fetal lungs (9). Cao et al. showed that maternal exposure to systemic endotoxin in pregnant rats increases pulmonary inflammation in the pups, altered gene expression of molecules involved in alveologenesis, and delayed morphological maturation (6). Salminen et al. found that, following systemic maternal endotoxin administration, the inflammatory signal is rapidl...

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supporting

confidence: 66%

supporting

confidence: 64%

Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury?

Lingappan

Moorthy

2015

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…Interestingly, it has been reported that diets high in poly-unsaturated fatty acids may significantly decrease mortality risk while improving clinical outcomes in patients experiencing acute lung injury or acute respiratory distress syndrome (37). We have recently demonstrated that treatment with the omega-3 fatty acid docosahexaenoic acid for one week prior to a single DE exposure significantly reduced neutrophil influx and pro-inflammatory cytokine production (38). Yet, no previous studies have reported a role for SPM in organic dust-induced inflammation or identified the specific effects that MaR1 may influence during these lung inflammatory processes.…”

Section: Discussionmentioning

confidence: 99%

Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust

Nordgren¹,

Bauer²,

Heires³

et al. 2015

Translational Research

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Agriculture industry workers are at a higher risk for chronic bronchitis and obstructive pulmonary diseases, and current therapeutics are not entirely effective. We previously found that the specialized pro-resolving lipid mediator (SPM) maresin-1 (MaR1) reduced pro-inflammatory cytokine release and intracellular adhesion molecule-1 (ICAM-1) expression in bronchial epithelial cells exposed to extracts of organic dust (DE) derived from swine confinement facilities in vitro. The objective of this study was to determine whether MaR1 is effective at limiting lung inflammation associated with acute and repetitive exposures to DE in an established murine model of inhalant dust exposures. C57Bl/6 mice were treated with MaR1 or vehicle control and intranasally instilled with DE once or daily for 3 weeks. Bronchial alveolar lavage fluid was analyzed for total and differential cell counts and pro-inflammatory cytokine levels, and lung tissues were assessed for histopathology and ICAM-1 expression. In both single and repetitive DE exposure studies, MaR1 significantly decreased bronchoalveolar lavage neutrophil infiltration, IL-6, TNF-α, and CXCL1 levels without altering repetitive DE-induced bronchiolar/alveolar inflammation or lymphoid aggregate formation. Lung tissue ICAM-1 expression was also reduced in both single and repetitive exposure studies. These data suggest that MaR1 might contribute to an effective strategy to reduce airway inflammatory diseases induced by agricultural-related organic dust environmental exposures.

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“…Actually, it is well known that the organic acids (esters) have various pharmacological activities, such as antiinflammatory activity . And total organic acids have also been reported to have the activities of antitussive effect in crude and processed Pinelliae Rhizoma.…”

Section: Resultsmentioning

confidence: 73%

Rapid characterization of chemical constituents of Platycodon grandiflorum and its adulterant Adenophora stricta by UPLC‐QTOF‐MS/MS

et al. 2017

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Platycodon grandiflorum (PG) is extensively used for treating cough, excessive phlegm, sore throat, bronchitis and asthma, whereas Adenophora stricta (AS) is commonly used to reduce phlegm, clear lung and tonify stomach. Due to similar appearances, PG is sometimes adulterated with cheap AS so as to gain profits. And this will inevitably result in different pharmacological property. In order to further clarify the differences in the chemical composition of these two Chinese herbs, the ultra-high performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry coupled with UNIFI platform was used to establish a reliable, simple, sensitive and rapid analytical method. Seventy-five compounds, including triterpenoid saponins, organic acids, flavonoids, steroids, phenols, etc., were identified from PG based on MS data and retention time under the optimized conditions. Meanwhile, 57 compounds including triterpenoid saponins, organic acids, steroids, phenols, alkaloids, etc. were identified from AS. Among all the identified compounds, there were only 14 common components (mainly organic acids) existing in two herbs, and most of the other chemical compositions are totally different between the two herbs. Based on the results, AS cannot substitute for PG. In addition, PG adulterated with AS will lead a poor efficacy in clinical application. In addition, the systematic comparison of similarities and differences between two Chinese herbs will provide reliable characterization profiles to clarify the pharmacological fundamental substances.

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The Omega-3 Fatty Acid Docosahexaenoic Acid Attenuates Organic Dust-Induced Airway Inflammation

Cited by 34 publications

References 58 publications

Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury?

Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury?

Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust

Rapid characterization of chemical constituents of Platycodon grandiflorum and its adulterant Adenophora stricta by UPLC‐QTOF‐MS/MS

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