The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NO<sup>•</sup> response of isolated rat aorta

Rietjens, Saskia J.; Bast, Aalt; Vente, Jan de; Haenen, Guido R.M.M.

doi:10.1152/ajpheart.00755.2006

Cited by 73 publications

(62 citation statements)

References 21 publications

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“…According to previous study, the antioxidant agent would protect the aorta from further oxidative damage (Rietjens et al, 2007). This condition would then inhibit the ultrastructural changes of aorta thus prevent the development of atherosclerotic lesion as shown in our study.…”

Section: Electron Microscopic Observationsupporting

confidence: 68%

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

Zainalabidin¹,

Budin²,

Anuar³

et al. 2018

J App Pharm Sci

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Chronic hyperglycaemia produces excessive free radicals which could lead to diabetic complications. Hibiscus sabdariffa Linn. is proven to have high antioxidant and antihyperlipidemic properties. The aim of the study was to investigate the effects of H. sabdariffa polyphenol-rich extract (HPE) in the aorta of diabetic rats. Twenty-four male rats were randomly divided into three groups, i.e. non-diabetes mellitus (NDM), diabetes mellitus (DM) and diabetes mellitus with HPE (DM + HPE). HPE at 100 mg/kg or saline as control vehicle were administered daily through oral gavage for 28 days prior to sacrification and the aorta was isolated for further analysis. The glucose level in DM + HPE was significantly lower compared to DM, indicating its potential as an antidiabetic agent. Conversely, catalase (CAT), superoxide dismutase (SOD) activity and the level of glutathione (GSH) in DM + HPE were significantly higher than DM. The level of malondialdehyde (MDA) and protein carbonyl were significantly lower in DM + HPE than DM. Lipid profile analysis demonstrated a significant decrease in triglyceride, total cholesterol and LDL-C in DM + HPE compared to DM, however, HDL-C was significantly increased. Microscopic observation showed a disrupted morphology of the thoracic aorta in diabetic rats. HPE may exert protective effects by acting as an antidiabetic, antihyperlipidemic and antioxidant agent to the thoracic aorta in diabetic rats.

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Section: Electron Microscopic Observationsupporting

confidence: 68%

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

Zainalabidin¹,

Budin²,

Anuar³

et al. 2018

J App Pharm Sci

View full text Add to dashboard Cite

show abstract

“…This event requires the achievement of high concentrations of polyphenols (in the mM range), concentrations hardly reached in humans [6]. In fact, a regular consumption of olive oil, like it happens in a Mediterranean diet, allows to rich blood concentrations of HT equivalent to 50-160 nM [44][45][46].…”

Section: Discussionmentioning

confidence: 99%

Oleuropein and hydroxytyrosol inhibit MCF‐7 breast cancer cell proliferation interfering with ERK1/2 activation

Sirianni

Chimento

Luca

et al. 2010

Molecular Nutrition Food Res

144

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The growth of many breast tumors is stimulated by estradiol (E2), which activates a classic mechanism of regulation of gene expression and signal transduction pathways inducing cell proliferation. Polyphenols of natural origin with chemical similarity to estrogen have been shown to interfere with tumor cell proliferation. The aim of this study was to investigate whether hydroxytyrosol (HT) and oleuropein (OL), two polyphenols contained in extra-virgin olive oil, can affect breast cancer cell proliferation interfering with E2-induced molecular mechanisms. Both HT and OL inhibited proliferation of MCF-7 breast cancer cells. Luciferase gene reporter experiments, using a construct containing estrogen responsive elements able to bind estrogen receptor alpha (ERalpha) and the study of the effects of HT or OL on ERalpha expression, demonstrated that HT and OL are not involved in ERalpha-mediated regulation of gene expression. However, further experiments pointed out that both OL and HT determined a clear inhibition of E2-dependent activation of extracellular regulated kinase1/2 belonging to the mitogen activating protein kinase family. Our study demonstrated that HT and OL can have a chemo-preventive role in breast cancer cell proliferation through the inhibition of estrogen-dependent rapid signals involved in uncontrolled tumor cell growth.

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“…Many of these benefits have been attributed to the phenolic components of olive oil, the prime fat source in the Mediterranean diet. The major phenolic compounds in this oil are tyrosol (Tyr, 4-(2-hydroxyethyl) phenol) and hydroxytyrosol (HTyr, 4-(2-Hydroxyethyl)-1,2-benzenediol) [32,33]. These compounds are also present in white wines [34].…”

Section: Introductionmentioning

confidence: 98%

“…Many of these benefits can be associated with its well-recognized antioxidant activity [55][56][57][58][59][60][61][62][63], which has been reported to be higher than that of a-tocopherol [64][65][66]. HTyr has been proven to efficiently scavenge peroxyl [67][68][69], NO [33], tert-butylhydroperoxide [70], and 2,2-diphenyl-1-picrylhydrazyl (DPPH) [71] radicals. It is also a potent scavenger of hydroxyl radical [33,43], which was attributed to its catechol moiety [33].…”

Section: Introductionmentioning

confidence: 99%

A quantum chemical study on the free radical scavenging activity of tyrosol and hydroxytyrosol

et al. 2012

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The free radical scavenging activity of hydroxytyrosol (HTyr) and tyrosol (Tyr) has been studied in aqueous and lipid solutions, using the density functional theory. Four mechanisms of reaction have been considered: single electron transfer (SET), sequential electron proton transfer (SEPT), hydrogen transfer (HT), and radical adduct formation. It was found that while SET and SEPT do not contribute to the overall reactivity of HTyr and Tyr toward Á OOH and Á OCH 3 radicals, they can be important for their reactions with Á OH, Á OCCl 3 , and Á OOCCl 3 . The Á OOH-scavenging activity of HTyr and Tyr was found to take place exclusively by HT, and it is also predicted to be the main mechanism for their reactions with Á OCH 3 . HT is proposed as the main mechanism for the scavenging activity of HTyr and Tyr when reacting with other Á OR and Á OOR radicals, provided that R is an alkyl or an alkenyl group. The major products of reaction are predicted to be the phenoxyl radicals. In addition, Tyr was found to be less efficient than HTyr as free radical scavenger. Moreover, while HTyr is predicted to be a good peroxyl scavenger, Tyr is predicted to be only moderately for that purpose.

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The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NO^• response of isolated rat aorta

Abstract: Rietjens SJ, Bast A, de Vente J, Haenen GR. The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NO• response of isolated rat aorta.

Cited by 73 publications

References 21 publications

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

Oleuropein and hydroxytyrosol inhibit MCF‐7 breast cancer cell proliferation interfering with ERK1/2 activation

A quantum chemical study on the free radical scavenging activity of tyrosol and hydroxytyrosol

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