The Oligomer Species: Mechanistics and Biochemistry

Stefani, Massimo

doi:10.1002/9783527654185.ch7

Cited by 2 publications

(3 citation statements)

References 156 publications

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“…As many recent studies have revealed (27,38), the binding of oligomers onto the cell membrane may cause the local destabilization and permeation of the latter or form unintended pores, giving rise to abnormal leakage of ions (especially Ca 2þ ) and eventually the death of cells. According to this general picture, we denote the cells by Cðs; wÞ, where s ¼ 0=1 and w˛½0; 1.…”

Section: Methodsmentioning

confidence: 99%

“…In the second part, we need to model the interaction between oligomers and cells. As many recent literatures have revealed [Fandrich12,Stefani13], the binding of oligomers onto the cell membrane may cause the breakage of the latter, give rise to the leakage of ions (especially Ca 2+ ) and eventually the death of cells. Based on this general picture, we assume that the cells under consideration can adopt two different states: one is the normal state (denoted by C ), the other is the damaged state caused by oligomer binding (denoted by * C ).…”

Section: The Kinetics Of Amyloid Formation and Cell Damage Both Can B...mentioning

confidence: 99%

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A Kinetic Model for Cell Damage Caused by Oligomer Formation

Hong

Huang

Yong

2015

Biophysical Journal

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It is well known that the formation of amyloid fiber may cause invertible damage to cells, although the underlying mechanism has not been fully understood. In this article, a microscopic model considering the detailed processes of amyloid formation and cell damage is constructed based on four simple assumptions, one of which is that cell damage is raised by oligomers rather than mature fibrils. By taking the maximum entropy principle, this microscopic model in the form of infinite mass-action equations together with two reaction-convection partial differential equations (PDEs) has been greatly coarse-grained into a macroscopic system consisting of only five ordinary differential equations (ODEs). With this simple model, the effects of primary nucleation, elongation, fragmentation, and protein and seeds concentration on amyloid formation and cell damage have been extensively explored and compared with experiments. We hope that our results will provide new insights into the quantitative linkage between amyloid formation and cell damage.

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Section: Methodsmentioning

confidence: 99%

Section: The Kinetics Of Amyloid Formation and Cell Damage Both Can B...mentioning

confidence: 99%

A Kinetic Model for Cell Damage Caused by Oligomer Formation

Hong

Huang

Yong

2015

Biophysical Journal

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“…However, this view has been challenged again and again in recent years, with accumulated evidences coming from the morphology, atomic structure and functions of oligomers and fibrils both in vitro and in vivo [141,142]. Now heterogeneous oligomers are generally believed far more toxic than mature fibrils [143][144][145]. Meanwhile, solvable monomers are considered as less harmful to cells even in a misfolded state [146,147].…”

Section: E How Cytotoxicity Arisementioning

confidence: 99%

Statistical Mechanics and Kinetics of Amyloid Fibrillation

Hong

Lee

Huang

2017

Biophysics and Biochemistry of Protein Aggregation

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Amyloid fibrillation is a protein self-assembly phenomenon that is intimately related to wellknown human neurodegenerative diseases. During the past few decades, striking advances have been achieved in our understanding of the physical origin of this phenomenon and they constitute the contents of this review. Starting from a minimal model of amyloid fibrils, we explore systematically the equilibrium and kinetic aspects of amyloid fibrillation in both dilute and semi-dilute limits. We then incorporate further molecular mechanisms into the analyses. We also discuss the mathematical foundation of kinetic modeling based on chemical mass-action equations, the quantitative linkage with experimental measurements, as well as the procedure to perform global fitting.

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The Oligomer Species: Mechanistics and Biochemistry

Cited by 2 publications

References 156 publications

A Kinetic Model for Cell Damage Caused by Oligomer Formation

A Kinetic Model for Cell Damage Caused by Oligomer Formation

Statistical Mechanics and Kinetics of Amyloid Fibrillation

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