The olfactory function in patients with common variable immunodeficiency

Magliulo, Giuseppe; Iannella, Giannicola; Ciofalo, Andrea; Angeletti, Diletta; Pulvirenti, Federica; Quinti, Isabella

doi:10.1016/j.anorl.2018.02.003

Cited by 3 publications

(8 citation statements)

References 28 publications

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“…The study population consisted of 30 patients with CVID, 18 with hypogammaglobulinemia, and 10 with SAD. Furthermore, the study found a statistically significant reduction in sinus surgeries after IVIG therapy 26 . Reeder et al.…”

Section: Resultsmentioning

confidence: 85%

“…In this study, 19% of the patients had undergone FESS and needed to be on Ig replacement therapy due to continued infections. Only two patients (3.4%) needed FESS while on Ig therapy for continued symptoms 26 . Another study by Hoehle et al.…”

Section: Resultsmentioning

confidence: 95%

“…This yielded a total of 42 papers included in the systematic review (Figure 1). 8–49 The Oxford levels of evidence assigned included eight level 3 studies, and 34 level 4 studies, encompassing case series/retrospective reviews, case–control, and prospective studies. Additionally, four systematic reviews related to this topic were identified 4,5,50,51 .…”

Section: Resultsmentioning

confidence: 99%

“…Treatment of patients with rhinosinusitis and PAD Twenty of the included studies discussed treatment of PAD in patients with refractory rhinosinusitis. 10,11,17,20,21,25,26,[28][29][30][32][33][34][35][36]39,44,[46][47][48] Treatment options discussed in these studies included clinical response to the Pneumovax-23 vaccination, prophylaxis antibiotics, immunoglobulin (Ig) replacement therapy, and surgical treatment.…”

Section: 31mentioning

confidence: 99%

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Evaluation and treatment of rhinosinusitis with primary antibody deficiency in adults: Evidence‐based review with recommendations

Makary

Luong

Azar

et al. 2023

Int Forum Allergy Rhinol

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BackgroundThere is clear evidence that the prevalence of primary antibody deficiency (PAD) is higher in patients with recurrent and chronic rhinosinusitis (CRS) than in the general population. The purpose of this multi‐institutional and multidisciplinary evidence‐based review with recommendations (EBRR) is to thoroughly review the literature on rhinosinusitis with PAD, summarize the existing evidence, and provide recommendations on the evaluation and management of rhinosinusitis in patients with PAD.MethodsThe PubMed, EMBASE, and Cochrane databases were systematically reviewed from inception through August 2022. Studies on the evaluation and management of rhinosinusitis in PAD patients were included. An iterative review process was utilized in accordance with EBRR guidelines. Levels of evidence and recommendations on the evaluation and management principles for PAD were generated.ResultsA total of 42 studies were included in this evidence‐based review. These studies were evaluated on incidence of PAD in rhinosinusitis patients, incidence of rhinosinusitis in PAD patients, and on the different treatment modalities used and their outcome. The aggregate quality of evidence was varied across reviewed domains.ConclusionBased on the currently available evidence, PAD can occur in up to 50% of patients with recalcitrant CRS. Despite the presence of multiple studies addressing rhinosinusitis and PAD, the level of evidence supporting different treatment options continues to be lacking. Optimal management requires a multidisciplinary approach through collaboration with clinical immunology. There is need for higher‐level studies that compare different treatments in patients with PAD and rhinosinusitis.

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Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: 31mentioning

confidence: 99%

See 2 more Smart Citations

Evaluation and treatment of rhinosinusitis with primary antibody deficiency in adults: Evidence‐based review with recommendations

Makary

Luong

Azar

et al. 2023

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

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“…In these patients, altered levels of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in olfactory cleft mucus are associated with reduced olfactory identification scores (Wu et al 2018). Additionally, clinical studies indicate that immunodeficiencies (Magliulo et al 2019) or uncontrolled activation of immune cells occurring in autoimmune diseases (Shin et al 2019) can alter the capacity to smell, typically at the onset of disease. There are also olfactory disorders associated with immunomodulatory therapies, such as interferon-α treatment used to treat patients with hepatitis (Maruyama et al 1998;Kraus and Vitezic 2000;Mayet 2007).…”

Section: Osn Activity and Inflammation: Roles Of The Immune Systemmentioning

confidence: 99%

Modulation of olfactory signal detection in the olfactory epithelium: focus on the internal and external environment, and the emerging role of the immune system

2021

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Detection and discrimination of odorants by the olfactory system plays a pivotal role in animal survival. Olfactory-based behaviors must be adapted to an ever-changing environment. Part of these adaptations includes changes of odorant detection by olfactory sensory neurons localized in the olfactory epithelium. It is now well established that internal signals such as hormones, neurotransmitters, or paracrine signals directly affect the electric activity of olfactory neurons. Furthermore, recent data have shown that activity-dependent survival of olfactory neurons is important in the olfactory epithelium. Finally, as olfactory neurons are directly exposed to environmental toxicants and pathogens, the olfactory epithelium also interacts closely with the immune system leading to neuroimmune modulations. Here, we review how detection of odorants can be modulated in the vertebrate olfactory epithelium. We choose to focus on three cellular types of the olfactory epithelium (the olfactory sensory neuron, the sustentacular and microvillar cells) to present the diversity of modulation of the detection of odorant in the olfactory epithelium. We also present some of the growing literature on the importance of immune cells in the functioning of the olfactory epithelium, although their impact on odorant detection is only just beginning to be unravelled.

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Olfactory function in patients with obstructive sleep apnea: a meta-analysis study

Iannella

Magliulo

Maniaci

et al. 2020

Eur Arch Otorhinolaryngol

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The olfactory function in patients with common variable immunodeficiency

Cited by 3 publications

References 28 publications

Evaluation and treatment of rhinosinusitis with primary antibody deficiency in adults: Evidence‐based review with recommendations

Evaluation and treatment of rhinosinusitis with primary antibody deficiency in adults: Evidence‐based review with recommendations

Modulation of olfactory signal detection in the olfactory epithelium: focus on the internal and external environment, and the emerging role of the immune system

Olfactory function in patients with obstructive sleep apnea: a meta-analysis study

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