The oil from Moringa oleifera seeds accelerates chronic skin wound healing

Ventura, Ana Clara Sans Salomão Brunow; Paula, Thalita Cristina de; Gonçalves, Jenifer Pendiuk; Soley, Bruna da Silva; Cretella, Ananda Beatriz Munhoz; Otuki, Michel Fleith; Cabrini, Daniela Almeida

doi:10.1016/j.phyplu.2021.100099

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…It is responsible for efficiently accelerating inflammation, thus, appropriately stimulating fibroblast activity, wound myofibroblast contraction, and matrix deposition in chronic wound healing in immunosuppressed and diabetic mice. 59 Water-soluble lectins from M. oleifera seeds promoted immunomodulation in human peripheral blood mononuclear cells that induced a potential wound healing profile through activation of CD8+ T lymphocytes. 60 The aqueous extract of M. oleifera bark increases the amount of hydroxyproline (a direct estimate of collagen synthesis) and also opposes the action of dexamethasone to some extent on collagen synthesis, maturation, deposition, epithelialization period, and hydroxyproline content.…”

Section: Effect Of M Oleifera Extract On Chronic Woundsmentioning

confidence: 99%

Moringa oleifera Lam. to accelerate wound healing: a review

Jaya,

Syamsunarno,

Sahiratmadja

2023

JMedScie

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An injury to the skin that disrupts the soft tissue may form a wound. The healing process in response to injury is a dynamic and well-regulated process of cellular, humoral, and molecular mechanisms that consists of four partly overlapping phases: hemostasis, inflammation, proliferation, and remodeling. An impaired wound-healing process may cause a formation of an abnormal scar and chronic wounds, leading to a reduced life quality. Therefore, it needs an optimal prevention strategy. Many modalities have been claimed to accelerate wound healing. The trend of using natural products is increasing in most Southeast Asian countries due to their biodiversity. Nowadays, studies on natural compounds are increasing to accelerate wound healing. Moringa oleifera Lam. is a high-value plant that each part of it has a high nutritional value as well as a great range of medicinal uses, including anti-inflammatory, antimicrobial, antioxidant, and wound healing properties. In this review, we have explored the M. oleifera that are very rich in vitamins, minerals, fatty acids, and phytochemical compounds like quercetin, kaempferol, and vicenin-2, that play a role in the wound healing process. Moreover, these compounds may enhance the healing of wounds with pathological conditions such as diabetes, immunocompromised and persistent infection.

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Section: Effect Of M Oleifera Extract On Chronic Woundsmentioning

confidence: 99%

Moringa oleifera Lam. to accelerate wound healing: a review

Jaya,

Syamsunarno,

Sahiratmadja

2023

JMedScie

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“…Waktu ini lebih cepat dibandingkan kelompok control tanpa penggunaan salep atau obat apapun yang membutuhkan waktu 14 hari. (Ventura et al, 2021). Akan tetapi pada sampel dengan kondisi immunosuppressed membutuhkan waktu lebih lama yaitu 12 hari dari pada kondisi sehat.…”

Section: Moringa Oleifera Dapat Mempercepat Penyembuhan Lukaunclassified

“…Dari penelitian yang telah dilakukan pada artikel ini menunjukkan baik kondisi sehat maupun kondisi lainnya, penggunaan ekstrak biji kelor dari Moringa oleifera dapat mempercepat penutupan luka. (Ventura et al, 2021).…”

Section: Moringa Oleifera Dapat Mempercepat Penyembuhan Lukaunclassified

Ekstrak Moringa Oleifera Mempercepat Proses Penyembuhan Luka: Systematic Review

Asrul¹,

Rivai²,

Syisnawati³

et al. 2023

far

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Kulit merupakan organ terluar dan terbesar pada tubuh yang berfungsi sebagai barrier dari lingkungan eksternal. Luka yang terjadi pada jaringan kulit dapat menjadi lesi atau penyakit. Mekanisme penyembuhan luka dilakukan untuk melindungi tubuh. Artikel ini bertujuan untuk mengertahui peran ekstrak Moringa Oleifera pada system imun dalam proses penyembuhan luka. Metode yang digunakan adalah sistematik review. Penelusuran artikel dilakukan pada 5 database yaitu : PubMed, Science Direct, ProQuest, Springer Link dan Google Scholar. Data yang diperoleh dari seleksi literatur sejumlah tujuh dari 198 artikel. Hasil dari review ini menunjukkan bahwa ekstrak Moringa oleifera mempercepat penyembuhan luka. Moringa oleifera juga efektif pada beragam mekanisme seberti antimikroba, antioksidan, proliferasi, penutupan luka lebih cepat. Pemanfataan ekstrak Moringa oleifera dapat berasal dari ekstrak biji ataupun daun dan dimanfaatkan baik pada penyembuhan luka pada kondisi normal, diabetes, dan infeksi patogen.

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“…Mauritia flexuosa oil is rich in fatty acids, has an immunomodulatory character, acting as a chemotactic agent and an angiogenesis promoter, and may interfere with the inflammatory process [23][24][25][26][27][28][29][30][31][32]. It has already been observed that extra virgin olive oil, Moringa oleifera oil, and Melaleuca alternifolia oil have demonstrated promising efficacy in the treatment, healing, and closure of wounds through their anti-inflammatory, antioxidant, antimicrobial properties and by stimulating the angiogenic activities necessary for wound healing [72][73][74]. The combination of biomaterials has a common interest because they act on molecular and cellular events that aim to repair the defect in tissue integrity [75,76].…”

Section: Healing Activitymentioning

confidence: 99%

Potential Wound Healing Effect of Gel Based on Chicha Gum, Chitosan, and Mauritia flexuosa Oil

et al. 2022

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Wounds are considered a clinically critical issue, and effective treatment will decrease complications, prevent chronic wound formation, and allow rapid healing. The development of products based on naturally occurring materials is an efficient approach to wound healing. Natural polysaccharides can mimic the extracellular matrix and promote cell growth, thus making them attractive for wound healing. In this context, the aim of this work was to produce a gel based on chicha gum, chitosan, and Mauritia flexuosa oil (CGCHO) for wound treatment. TG and DTG analyzed the thermal behavior of the materials, and SEM investigated the surface roughness. The percentages of total phenolic compounds, flavonoids, and antioxidants were determined, presenting a value of 81.811 ± 7.257 µmol gallic acid/g Mauritia flexuosa oil, 57.915 ± 0.305 µmol quercetin/g Mauritia flexuosa oil, and 0.379 mg/mL, respectively. The anti-inflammatory was determined, presenting a value of 10.35 ± 1.46% chicha gum, 16.86 ± 1.00% Mauritia flexuosa oil, 10.17 ± 1.05% CGCHO, and 15.53 ± 0.65% chitosan, respectively. The materials were tested against Gram-negative (Klebsiella pneumoniae) and Gram-positive (Staphylococcus aureus) bacteria and a fungus (Candida albicans). The CGCHO formulation showed better antimicrobial activity against Gram-positive bacteria. In addition, an in vivo wound healing study was also performed. After 21 days of treatment, the epidermal re-epithelialization process was observed. CGCHO showed good thermal stability and roughness that can help in cell growth and promote the tissue healing process. In addition to the good results observed for the antimicrobial, antioxidant, anti-inflammatory activities and providing wound healing, they provided the necessary support for the healing process, thus representing a new approach to the wound healing process.

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The oil from Moringa oleifera seeds accelerates chronic skin wound healing

Cited by 9 publications

References 28 publications

Moringa oleifera Lam. to accelerate wound healing: a review

Moringa oleifera Lam. to accelerate wound healing: a review

Ekstrak Moringa Oleifera Mempercepat Proses Penyembuhan Luka: Systematic Review

Potential Wound Healing Effect of Gel Based on Chicha Gum, Chitosan, and Mauritia flexuosa Oil

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