The off-label use, utility and potential value of tDCS in the clinical care of particular neuropsychiatric conditions

Bikson, Marom; Paneri, Bhaskar; Giordano, James

doi:10.1093/jlb/lsw044

Cited by 10 publications

(5 citation statements)

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“…In the main, it will be important to weigh and balance the potential benefits and harms of commission (ie, engaging tES) and omission (ie, not engaging/using tES). 219,220,224,225 Information from the biomedical research, direct-to-consumer, and do-it-yourself communities suggests and supports broader use, as well as the utility and effectiveness of tES. Some of this information may be anecdotal and derived from case and/or case series reports, yet it is nevertheless vital to document and follow.…”

Section: The Trajectory and Tasks Of Research In Tes And Its Translatmentioning

confidence: 99%

Mechanisms and Effects of Transcranial Direct Current Stimulation

et al. 2017

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The US Air Force Office of Scientific Research convened a meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine to discuss most pressing issues facing ongoing research in the field of transcranial direct current stimulation (tDCS) and related techniques. In this study, we present opinions prepared by participants of the meeting, focusing on the most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research. Scientific, medical, and ethical considerations support the ongoing testing of tDCS in healthy and clinical populations, provided best protocols are used to maximize safety. Notwithstanding the need for ongoing research, promising applications include enhancing vigilance/attention in healthy volunteers, which can accelerate training and support learning. Commonly, tDCS is used as an adjunct to training/rehabilitation tasks with the goal of leftward shift in the learning/treatment effect curves. Although trials are encouraging, elucidating the basic mechanisms of tDCS will accelerate validation and adoption. To this end, biomarkers (eg, clinical neuroimaging and findings from animal models) can support hypotheses linking neurobiological mechanisms and behavioral effects. Dosage can be optimized using computational models of current flow and understanding dose–response. Both biomarkers and dosimetry should guide individualized interventions with the goal of reducing variability. Insights from other applied energy domains, including ionizing radiation, transcranial magnetic stimulation, and low-level laser (light) therapy, can be prudently leveraged.

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Section: The Trajectory and Tasks Of Research In Tes And Its Translatmentioning

confidence: 99%

Mechanisms and Effects of Transcranial Direct Current Stimulation

et al. 2017

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“…Transcranial brain stimulation techniques are already being used as an adjuvant and off‐label therapeutic option to treat neuropsychiatric and neurological disorders such as depression, chronic migraine and pain syndromes . Specifically, transcranial direct current stimulation (tDCS) facilitates or inhibits neuronal activity and therefore temporarily modulates local neuronal processes, as well as complex cortical functions .…”

Section: Introductionmentioning

confidence: 99%

Double transcranial direct current stimulation of the brain increases cerebral energy levels and systemic glucose tolerance in men

Wardzinski¹,

Friedrichsen²,

Dannenberger³

et al. 2019

J Neuroendocrinology

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Transcranial direct current stimulation (tDCS) is a neuromodulatory method that has been tested experimentally and has already been used as an adjuvant therapeutic option to treat a number of neurological disorders and neuropsychiatric diseases. Beyond its well known local effects within the brain, tDCS also transiently promotes systemic glucose uptake and reduces the activity of the neurohormonal stress axes. We aimed to test whether the effects of a single tDCS application could be replicated upon double stimulation to persistently improve systemic glucose tolerance and stress axes activity in humans. In a single‐blinded cross‐over study, we examined 15 healthy male volunteers. Anodal tDCS vs sham was applied twice in series. Systemic glucose tolerance was investigated by the standard hyperinsulinaemic‐euglycaemic glucose clamp procedure, and parameters of neurohormonal stress axes activity were measured. Because tDCS‐induced brain energy consumption has been shown to be part of the mechanism underlying the assumed effects, we monitored the cerebral high‐energy phosphates ATP and phosphocreatine by 31phosphorus magnetic resonance spectroscopy. As hypothesised, analyses revealed that double anodal tDCS persistently increases glucose tolerance compared to sham. Moreover, we observed a significant rise in cerebral high‐energy phosphate content upon double tDCS. Accordingly, the activity of the neurohormonal stress axes was reduced upon tDCS compared to sham. Our data demonstrate that double tDCS promotes systemic glucose uptake and reduces stress axes activity in healthy humans. These effects suggest that repetitive tDCS may be a future non‐pharmacological option for combating glucose intolerance in type 2 diabetes patients.

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“…Here, we offer a perspective on tDCS for the enhancement of physical performance in sport. The ethical and legal implications of the transition of tDCS from academic experimental work to general-public use, are discussed elsewhere (Janssens and Kraft, 2012; Bain et al, 2015; Fregni et al, 2015; Bikson et al, 2016a; Kuersten and Hamilton, 2016; Zettler, 2016). …”

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confidence: 99%