The oestrogen receptor 2 (<i>ESR2</i>) gene in female-pattern hair loss: replication of association with rs10137185 in German patients

Redler, Silke; Birch, Pattie; Drichel, Dmitriy; Hofmann, P; Dobson, K.; Böhmer, Anne C.; Becker, Jéssica; Giehl, Kathrin; Tazi-Ahnini, Rachid; Kruse, Roland; Wolff, Hans; Miesel, Anja; Fischer, Tobias W.; Böhm, Markus; Nuwayhid, R.; Bartels, Natalie Garcia; Lutz, G.; Becker, Tim; Blume-Peytavi, Ulrike; Nöthen, Markus M.; Messenger, A.G.; Betz, Regina C.

doi:10.1111/bjd.12756

Cited by 12 publications

(8 citation statements)

References 9 publications

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“…=.012); the strongest association was found for rs10137185 in the late‐onset FPHL subgroup ( P uncorr. =.010) . We had earlier investigated four variants in the ESR2 gene in our German/UK FPHL sample and found no association .…”

Section: Heritable Factors—the Present Status Of Fphl Genetic Researchmentioning

confidence: 75%

Genetics and other factors in the aetiology of female pattern hair loss

Redler

Messenger

Betz

2017

Experimental Dermatology

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Pattern hair loss is the most common form of hair loss in both women and men. Male pattern hair loss, also termed male androgenetic alopecia (M-AGA), is an androgendependent trait that is predominantly genetically determined. Androgen-mediated mechanisms are probably involved in female pattern hair loss (FPHL) in some women but the evidence is less strong than in M-AGA; other non-androgenic pathways, including environmental influences, may contribute to the aetiology. Genome-wide association studies have identified several genetic loci for M-AGA and have provided better insight into the underlying biology. However, the role of heritable factors in and it has long been assumed that FPHL shares the same aetiology;hence, the term "female androgenetic alopecia" is often applied to this condition. However, the role of androgens in causing FPHL is less clear than in men. The genetic studies performed so far have not led to any firm conclusions but rather suggest different pathways for M-AGA and FPHL.In this review, we summarize what is known about the aetiology of FPHL and its relationship to M-AGA. Our main focus is on the results of genetic studies performed within the last decade. We also discuss the role of endocrine and other factors in the pathogenesis. | PREVALENCEPublished data on the prevalence of FPHL show some variation between studies, perhaps reflecting the difficulty in classifying mild forms of the condition. However, all show an increasing prevalence with age. Studies in women of white European ethnicity in the USA, [2] UK [3] and Australia [4] record a prevalence of 3%-12% in the third decade, rising to 14%-28% in the sixth decade and 29%-56%

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Section: Heritable Factors—the Present Status Of Fphl Genetic Researchmentioning

confidence: 75%

Genetics and other factors in the aetiology of female pattern hair loss

Redler

Messenger

Betz

2017

Experimental Dermatology

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“…Even though initially Redler et al did not observe any significant correlations in the German and British populations, they did confirm the significance of rs10137185 in a later study involving the German population only. The authors pointed to potentially important variables such as the number of patients included in the study and a later stage of alopecia progression [22].…”

Section: Discussionmentioning

confidence: 99%

“…With respect to the CYP19A1 gene, 13 SNPs were selected, and with respect to the ESR2 gene, 11 SNPs were selected for analysis in the study (Table 2) [18][19][20][21][22][23][24][25][26][27]. The SNPs were selected based on literature data.…”

Section: Snp Selectionmentioning

confidence: 99%

The role of CYP19A1 and ESR2 gene polymorphisms in female androgenetic alopecia in the Polish population

Łukasik¹,

Kozicka²,

Pisarek³

et al. 2022

pdia

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Introduction: Androgenetic alopecia is the most common type of non-cicatricial alopecia both in male and female patients. The mechanism that leads to hair loss is similar in both sexes, but the underlying cause, and especially the role of genes and sex hormones in the pathogenesis of the disease in women has not fully been explained as of yet. So far, a few attempts have been made to assess selected SNPs for CYP19A1 and ESR2 genes, but their results are not unequivocal and fully reproducible. Aim: To investigate the association of 13 CYP19A1 and 11 ESR2 gene SNPs with female androgenetic alopecia (FAGA) in a population of Polish patients, including some already genotyped SNPs of possible importance for FAGA pathophysiology in other populations. Material and methods: Twenty-four genetic polymorphisms were analysed for the ESR2 and CYP19A1 genes in 117 patients with FAGA and 128 healthy subjects treated at the Department of Dermatology in Krakow. Results: In the studied Polish population, none of the selected SNPs, frequently detected in the Caucasian population and linked with the transformation pathway of sex hormones, showed a significant association with FAGA. Conclusions: Further studies into the genetic background of androgenetic alopecia are needed. Ethnic differences as well as the size of the studied population may be of great significance for the obtained results.

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“…Compared to androgenetic alopecia in men, less is known regarding the etiology of FPHL, 12 and several uncertainties regarding the role of androgens in FPHL still remain 13 . A higher frequency of alopecia in first‐degree male relatives of women with FPHL has been found, 12 and although genetic studies have suggested some association between the AR/EDA2 locus and the estrogen receptor (ESR2), available data are still inconclusive 12,14,15 . Despite the benign course of the disease, FPHL significantly affects the quality of life (QOL) of women 16‐19 .…”

Section: Introductionmentioning

confidence: 99%

“…13 A higher frequency of alopecia in first-degree male relatives of women with FPHL has been found, 12 and although genetic studies have suggested some association between the AR/EDA2 locus and the estrogen receptor (ESR2), available data are still inconclusive. 12,14,15 Despite the benign…”

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confidence: 99%

Accuracy of clinical diagnosis and videodermoscopy in female pattern hair loss

Mancilla

Restrepo²,

Sanclemente

2020

Skin Research and Technology

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Female androgenic alopecia (FAGA) or female pattern hair loss (FPHL) is a non-scarring hair disease characterized by progressive hair diminishment that leads to the decrease of its density in the scalp. [1][2][3][4] It begins after puberty and its prevalence increases progressively with age, affecting 3.1% to 6% of Asian women, 5-7 19% of Caucasian women in the United States, 8 38% of British women, 6,8,9 and 32.2% of Australian women. 10 In Colombia, there are no data regarding FPHL incidence and prevalence rates, but it is a very frequent cause of dermatological consultation in the city of Medellín. 11 Compared to androgenetic alopecia in men, less is known regarding the etiology of FPHL, 12 and several uncertainties regarding the role of androgens in FPHL still remain. 13 A higher frequency of alopecia in first-degree male relatives of women with FPHL has been found, 12 and although genetic studies have suggested some association between the AR/EDA2 locus and the estrogen receptor (ESR2), available data are still inconclusive. 12,14,15 Despite the benign

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The oestrogen receptor 2 (ESR2) gene in female-pattern hair loss: replication of association with rs10137185 in German patients

Cited by 12 publications

References 9 publications

Genetics and other factors in the aetiology of female pattern hair loss

Genetics and other factors in the aetiology of female pattern hair loss

The role of CYP19A1 and ESR2 gene polymorphisms in female androgenetic alopecia in the Polish population

Accuracy of clinical diagnosis and videodermoscopy in female pattern hair loss

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