The Octopamine Receptor Is a Possible Target for Eugenol-Induced Hyperactivity in the Blood-Sucking Bug Triatoma infestans (Hemiptera: Reduviidae)

Reynoso, Mercedes María Noel; Lucı́a, Alejandro; Zerba, Eduardo; Alzogaray, Raúl A.

doi:10.1093/jme/tjz183

Cited by 9 publications

(10 citation statements)

References 22 publications

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“…The rapid action of monoterpenes against some pests suggests a neurotoxic mode of action. This hypothesis was confirmed by Reynoso, et al [ 47 ], who have demonstrated repellent and insecticidal activity of eugenol against the blood-sucking bug Triatoma infestans (Klug; Reduviidae) through activation of the octopamine receptor.…”

Section: Plant Derived Insecticides That Affect the Nervous Systemmentioning

confidence: 52%

“…Previous studies have reported the presence of octopamine receptors in a large variety of insects, including, firefly, flies, nymphs, cockroaches and lepidopterans [ 46 , 47 , 48 ]. As these receptors do not conform to the receptor categories that have been recognized in vertebrates, agonists of octopamine receptors may be a valuable candidate for a commercial pesticide, once they are target-specific, less toxic to mammals and have a different mechanism of action when compared to the majority of pesticides currently in the market [ 47 ].…”

Section: Plant Derived Insecticides That Affect the Nervous Systemmentioning

confidence: 99%

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Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects, Applications and Challenges

Sylvestre²,

et al. 2021

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Pests and diseases are responsible for most of the losses related to agricultural crops, either in the field or in storage. Moreover, due to indiscriminate use of synthetic pesticides over the years, several issues have come along, such as pest resistance and contamination of important planet sources, such as water, air and soil. Therefore, in order to improve efficiency of crop production and reduce food crisis in a sustainable manner, while preserving consumer’s health, plant-derived pesticides may be a green alternative to synthetic ones. They are cheap, biodegradable, ecofriendly and act by several mechanisms of action in a more specific way, suggesting that they are less of a hazard to humans and the environment. Natural plant products with bioactivity toward insects include several classes of molecules, for example: terpenes, flavonoids, alkaloids, polyphenols, cyanogenic glucosides, quinones, amides, aldehydes, thiophenes, amino acids, saccharides and polyketides (which is not an exhaustive list of insecticidal substances). In general, those compounds have important ecological activities in nature, such as: antifeedant, attractant, nematicide, fungicide, repellent, insecticide, insect growth regulator and allelopathic agents, acting as a promising source for novel pest control agents or biopesticides. However, several factors appear to limit their commercialization. In this critical review, a compilation of plant-derived metabolites, along with their corresponding toxicology and mechanisms of action, will be approached, as well as the different strategies developed in order to meet the required commercial standards through more efficient methods.

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Section: Plant Derived Insecticides That Affect the Nervous Systemmentioning

confidence: 52%

Section: Plant Derived Insecticides That Affect the Nervous Systemmentioning

confidence: 99%

Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects, Applications and Challenges

Sylvestre²,

et al. 2021

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“…While, the locomotor activity in the blood-sucking bug increased when treated with low concentration of eugenol ( Moretti et al, 2017 ). The volatile component phentolamine hydrochloride prohibit locomotor activity of the immature Triatoma infestans ( Reynoso et al, 2020 ). While in our study, ablation, HCL, and two silicon compounds decrease walking abilities of fire ant workers.…”

Section: Discussionmentioning

confidence: 99%

Preference and effect of gustatory sense on sugar-feeding of fire ants

Jaleel

Shi

et al. 2021

PeerJ

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Background The red imported fire ant is one of the notorious species of ants all over the world. Sugar is one of the most important components of food and necessary for the survival of ants. Because more than 70% food of fire ants is honeydew produced by Homopteran insects such as aphids and scales. Methodology It is well known that beetles, flies, and honey bees can recognize the sugar taste through their legs and antennae, but in the case of fire ants, no records regarding gustatory sense were published. In the current study, considering the importance of sugar bait, we investigated the gustatory sense of the fire ant workers to sucrose via behavioral sequence and gustatory behavior. First, the feeding sequence (ethogram) of the fire ant workers on most preferred sugar (sucrose) solution was observed and categorized. Secondly, the gustatory behavior of treated fire ant workers (without flagellum and foreleg tarsi treated with HCL solution) was observed on the sucrose solution. In addition, using scanning electron microscopy (SEM) techniques, we identified the possible porous sensilla types on antenna flagellum and foreleg tarsi of fire ant workers. Results Based on the results of feeding sequence, foreleg tarsi of workers were the main body appendages in the detection of the sucrose droplet as compared to antennae flagellum and palps. Feeding time of treated workers with HCL solution was significantly decreased on sucrose solution as compared to those workers having no flagellum. While both types of treated workers have less feeding time in comparison to normal workers. Based on the results of feeding sequence analysis and feeding time, it is indicating that the foreleg tarsi of workers play a more important role in the detection of sucrose solution as compared to antennae flagellum. Based on the SEM results, sensilla chaetic, trichoid II, and basiconic I and II have a clear pore at their tip. This study provides a substantial basis for elucidating the gustatory function of antennal and tarsal sensilla on appendages of fire ant workers to sugars and further baits improvement for the management of fire ants.

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“…What mechanism is responsible for the fact that menthol and menthyl acetate synergise azamethiphos under conditions where eugenol does not synergise it? The answer could be in the nicotinic acetylcholinesterase receptors (nAChR), which are inhibited by both menthol and OP [39,40]. Then, it is possible that if menthol and azamethiphos bind in a non-competitive way on these receptors, their joint application would cause synergism.…”

Section: Discussionmentioning

confidence: 99%

Botanical monoterpenes synergise the toxicity of azamethiphos in the vector of Chagas disease, Triatoma infestans (Hemiptera: Reduviidae)

Reynoso

Seccacini

Zerba

et al. 2020

Tropical Med Int Health

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objective To investigate what toxicological interactions occur when binary combinations of azamethiphos and botanical monoterpenes (eugenol, menthol or menthyl acetate) are applied to Triatoma infestans. methods The toxicity of binary mixtures of azamethiphos and sublethal doses of a monoterpene (eugenol, menthol or menthyl acetate) was evaluated in nymphs of the first stage of T. infestans. Experiments using exposure to filter papers and topical application were carried out. Values of Lethal Concentration 50% (LC50) were calculated in the first case, and values of Lethal Dose 50% (LD50) in the second. results The LC50 of azamethiphos applied on filter paper was 50.3 µg/cm 2. However, when it was simultaneously applied with a sublethal concentration of monoterpene, its toxicity increased (LC50 with eugenol = 11.20 µg/cm 2 , LC50 with menthyl acetate = 5.30 µg/cm 2 , LC50 with menthol = 7.26 µg/cm 2). When applied topically, the LD50 of azamethiphos was 7.85 µg/insect, but its toxicity drastically increased when it was applied together with sublethal doses of menthol (LD50 = 0.00016 µg/insect) or menthyl acetate (LD50 = 0.00051 µg/insect). The simultaneous application with eugenol did not significantly change azamethiphos toxicity (LD50 = 12.79 µg/ insect). conclusions The toxicity of azamethiphos in T. infestans was synergised when it was applied together with eugenol, menthol or menthyl acetate on a filter paper. However, only menthol and menthyl acetate synergysed azamethiphos when mixtures were topically applied. The drastic effects of menthol and menthyl acetate in topical application experiments should be further studied as they could be the basis for developing more efficient triatomicidal products with a lower content of conventional insecticides than those currently used for controlling T. infestans. keywords kissing bug, Chagas disease, synergism, monoterpene, insecticide Sustainable Development Goals (SDGs): SDG 3 (good health and well-being), SDG 15 (life on land), SDG 17 (partnerships for the goals)

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The Octopamine Receptor Is a Possible Target for Eugenol-Induced Hyperactivity in the Blood-Sucking Bug Triatoma infestans (Hemiptera: Reduviidae)

Cited by 9 publications

References 22 publications

Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects, Applications and Challenges

Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects, Applications and Challenges

Preference and effect of gustatory sense on sugar-feeding of fire ants

Botanical monoterpenes synergise the toxicity of azamethiphos in the vector of Chagas disease, Triatoma infestans (Hemiptera: Reduviidae)

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