Three cross-cutting issues—bias and objectivity in social science research, normative standards to guide policy development, and subjectivity applied within moral contexts—are examined in relation to 2 research studies conducted in school and community settings. In each case, the focus of the study (health services in schools, teen pregnancy prevention programs) raised complex ethical and political concerns in designing and conducting research on topics that were highly contested and emotionally charged. Successful resolution of these issues depends upon the development of a new framework that allows researchers and policy makers to balance ethical, political, and scientific concerns in ways that do not privilege one over the other.