The Occurrence of Zinc in the Human Prostate Gland

Mawson, C. A.; Fischer, Michael

doi:10.1139/cjms52-043

Cited by 83 publications

(69 citation statements)

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“…In the rat prostate, high MT concentration was seen in the lateral prostate, which has a high zinc concentration (Gunn and Gould 1957;Muntzing et al 1977;Bataineh et al 1986;Umeyama et al 1987;Suzuki et al 1991). In human prostate, a high MT concentration in tissues of the peripheral zone, which also exhibit high zinc concentration has been described (Mawson and Fisher 1952;Suzuki et al 1991). MT secreted into the prostatic fluid by prostatic epithelial cells we have recently found using radioimmunoassay.…”

Section: Discussionmentioning

confidence: 99%

Binding of Metallothionein to Rat Spermatozoa.

Suzuki

Nakajima

Yamamoto

et al. 1994

Tohoku J. Exp. Med.

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Binding studies of metallothionein and rat spermatozoa were performed using 125I-Tyr-metallothionein (1251-MT). Reactions between 1251-MT and spermatozoa indicated that MT bound in two forms , namely, middle affinity (Kdl=2 x 10-9 M) binding and low affinity (Kd2=1 x 10_8 M) binding. Labeled MT binding to spermatozoa was inhibited by adding anti-MT antibody. Total binding reactions of MT were temperature and incubation time dependent. By transmission electron microscopy using a gold conjugate (indirect method), gold particles bound to MT were shown to bind to the cell membrane of the head and the proximal portion of the tail. By optical autoradiography, grains of labeled MT were localized mainly in the head and the proximal portion of the tail. By electron microscopical autoradiography, grains of labeled MT were identified mainly in the cell membrane of the head and tail and partly in the nucleus. These results suggest that MT has both specific and non-specific binding sites on the spermatozoal membrane. metallothionein (MT); spermatozoa; autoradiography; transmission electron microscopy Metallothionein (MT) is a metal-binding protein with a low molecular weight of approximately 6,000 and with high cysteine and sulfur content (Margoshes and Vallee 1957). It has been identified in a variety of organs, including the prostate (Waalkes et al. 1982;Bataineh et al. 1986;Umeyama et al. 1987;Suzuki et al. 1991), and binds class II-B metals, such as cadmium and zinc. Zinc is concentrated in the prostatic tissue and secreted into prostatic fluid (Mawson and Fisher

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Section: Discussionmentioning

confidence: 99%

Binding of Metallothionein to Rat Spermatozoa.

Suzuki

Nakajima

Yamamoto

et al. 1994

Tohoku J. Exp. Med.

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“…Zinc concentration is high in prostatic tissue and fluid (Mawson and Fischer 1952a;Gyorkey et al 1967 ;Anderson and Fair 1976;Ogunlewe et al 1989), and the concentration of zinc has been found to affect male infertility (Anderson et al 1976). This shows MT of the prostate binds to zinc.…”

Section: Resultsmentioning

confidence: 99%

“…The concentration of zinc is high in prostatic tissues and fluids (Mawson and Fischer 1952a;Gyorkey et al 1967; Anderson and Fair 1976;Ogunlewe and Osegbe 1989). We reported the localization of MT in the rat and human prostate by immunohistochemistry (Umeyama et al 1987; Suzuki et al 1991) The essential role of MT in the prostate gland remains unclear.…”

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confidence: 88%

Metallothionein of Prostatic Tissues and Fluids in Rats and Humans.

Suzuki

Yamanaka

Tamura

et al. 1992

Tohoku J. Exp. Med.

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“…There is good evidence that zinc may contribute to prostate cancer incidence. Total zinc levels in the prostate are 10 times higher than in other soft tissues (Mawson and Fisher, 1952). Uptake of zinc via a membrane transporter into prostatic epithelial cells is under the control of hormones (testosterone, prolactin) (Costello et al, 1999).…”

Section: Zincmentioning

confidence: 99%

‘Mealthy’ food: meat as a healthy and valuable source of micronutrients

Nöhr

Biesalski

2007

Animal

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Over the last two or three decades meat and especially liver have been looked upon as unhealthy food with high fat content and carcinogenic potential. In addition, its content of highly valuable micronutrients has mostly been ignored. As a result, the mean uptake and serum levels of several micronutrients in the population are below the recommended levels. In the meantime, the contamination of liver with heavy metals and other contaminants has fallen far below the allowed thresholds and sometimes even below the detection limit while its content of micronutrients like iron, folate, selenium or zinc are still high. As a further advantage, the bioavailability of many micronutrients often is better from meat and liver then from plant sources. Considering these advantages and the low content of contaminants in meat and liver leads us to propose that meat -including livershould be a regular part of a mixed and balanced healthy diet along with vegetables and fruits as the major components to ensure an optimal supply of micronutrients.

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The Occurrence of Zinc in the Human Prostate Gland

Cited by 83 publications

References 0 publications

Binding of Metallothionein to Rat Spermatozoa.

Binding of Metallothionein to Rat Spermatozoa.

Metallothionein of Prostatic Tissues and Fluids in Rats and Humans.

‘Mealthy’ food: meat as a healthy and valuable source of micronutrients

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