The occurrence of translocation (15;17) in acute promyelocytic leukemia: An update

Braekeleer, Marc De

doi:10.1016/0165-4608(86)90190-1

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…T h e second unusual feature was the lack of a t(15;17) which is associated with APL in 60-96% of studied patients (De Braekeleer 1986;. No chromosomal variants involving chromosomes 15 and 17 were detected.…”

Section: Discussionmentioning

confidence: 91%

Myelodysplastic syndrome transforming to acute promyelocytic‐like leukemia with trisomy and rearrangement of chromosome II

Najfeld¹,

Chen

Scalise³

et al. 1994

Genes Chromosomes & Cancer

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Variants of the t(15;17)(q22;q12-q21) chromosomal rearrangement associated with acute promyelocytic leukemia (APL) have been previously described and they frequently involve either chromosome 15 and/or 17. Previously we reported a rare variant t(11;17). We now describe two patients with myelodysplastic syndrome (MDS) that transformed to APL-like leukemia. Both had trisomy 11 at the diagnosis of APL-like leukemia. Following treatment for APL, patient 1 reverted to MDS and showed a normal karyotype. When leukemia recurred, his bone marrow karyotype was 47,XY,t(4;11), +11,der(22)t(1;22). Both patients were treated with all-trans retinoic acid (ATRA) for APL for 5 weeks, but failed to respond. The karyotype of patient 1 after ATRA treatment was 46,XY,t(4;11); the trisomy 11 had been lost and the bone marrow was replaced with immature myeloblasts without promyelocytes. In patient 2, the karyotype remained the same as at diagnosis, i.e., 47,X,-Y,dir ins(4;7),del(5), +6,del(7), +8, + 11,-18. Molecular analysis by reverse transcriptase PCR analysis showed the presence of wild type retinoic acid receptor alpha (RARA) and the absence of the PML-RARA chimeric gene associated with t(15;17). Additional analysis of PLZF, a new zinc finger gene associated with t(11;17), also showed the absence of this hybrid gene. These data support the concept that APL is a heterogeneous disorder and that variants with chromosome 11 rearrangement exist that do not respond to ATRA.

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Section: Discussionmentioning

confidence: 91%

Myelodysplastic syndrome transforming to acute promyelocytic‐like leukemia with trisomy and rearrangement of chromosome II

Najfeld¹,

Chen

Scalise³

et al. 1994

Genes Chromosomes & Cancer

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show abstract

“…Zarabi and R~s n e r '~ reported 12 cases of AML following treatment of NHL and reviewed the literature. Survival after the diagnosis of acute leukemia ranged from 3 days to 14 months with a median of 3 months.…”

Section: Discussionmentioning

confidence: 99%