The Occurrence of Squamous Epithelium in the Endometrium

Ms, Baggish; Jd, Woodruff

doi:10.1097/00006254-196702000-00008

Cited by 68 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several theories regarding the cellular origin of PESCC have been proposed: 1) reserve or stem cells located between the glandular basement membrane and the endometrial columnar cell layer;4 2) squamous metaplasia of the normal endometrium;5 and 3) heterotopic cervical tissue 6. It has been reported that vitamin A deficiency, anti-estrogen treatment, pyometra, chronic infection, uterine prolapse, myoma, intrauterine device, history of pelvic irradiation and curettage are associated with squamous metaplasia of the endometrium 2,5,7,8…”

Section: Discussionmentioning

confidence: 99%

Primary Endometrial Squamous Cell Carcinoma: A Case Report and Review of Relevant Literature on Korean Women

Lee

Choi

2012

Korean J Pathol

View full text Add to dashboard Cite

Primary endometrial squamous cell carcinoma (PESCC) is an extremely rare tumor with unclear pathogenesis. A 54-year-old postmenopausal woman presented with a 6-month history of vaginal bleeding. The patient was provisionally diagnosed with uterine submucosal leiomyoma. This was followed by total hysterectomy with a bilateral salpingo-oophorectomy under the laparoscopic guidance. Histopathologically, the tumor was PESCC which was accompanied by a lack of the tumor in the uterine cervix. The tumor showed positive immunoreactivity for p16INK4a. But there was no evidence of human papillomavirus (HPV) on in situ hybridization and HPV DNA chip analysis. We also present a review of the relevant literature on Korean women.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary Endometrial Squamous Cell Carcinoma: A Case Report and Review of Relevant Literature on Korean Women

Lee

Choi

2012

Korean J Pathol

View full text Add to dashboard Cite

show abstract

“…Various other situations including uterine artery embolisation of leiomyoma,60 vitamin A deficiency61 and even progestin therapy62 63 have been reported as possible aetiopathogenetic factors of ESM.…”

Section: Epithelial Emcsmentioning

confidence: 99%

Endometrial metaplasias and reactive changes: a spectrum of altered differentiation

2010

View full text Add to dashboard Cite

Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. Hormonal or irritative stimuli are the main inducing factors of EMCs, although some metaplasias have a mutational origin. EMCs vary from reactive, degenerative lesions to those able to associate with malignancy or those having a preneoplastic potential. The most common types of EMCs are ciliated tubal metaplasia (CTM) and mucinous metaplasia (MM), which occur in simple and complex glands, and possibly these architectural changes hold the same prognostic significance as they do in hyperplastic endometrioid lesions. Immunohistochemically, CTM is positive for LhS28, bcl-2, PAX2 and p16

show abstract

“…6 Further research supports this finding. [7][8][9] Human papilloma virus is known to have a definite role in the pathogenesis of SCC of the uterine cervix; however, its role in endometrial SCC is still to be determined. 6 In cases of PESCC, it is important to exclude cervical SCC extension into the endometrium and squamous differentiation of an endometrioid adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Primary Endometrial Squamous Cell Carcinoma In Situ: Report of a rare disease

Jetley¹,

Jairajpuri²,

Hassan³

et al. 2015

SQUMJ

View full text Add to dashboard Cite

Squamous cell carcinoma (SCC) of the endometrium, whether primary or secondary to cervical cancer, is a rare entity. Primary endometrial squamous cell carcinoma in situ is even more uncommon; it usually occurs in postmenopausal women and has a strong association with pyometra. We report a 60-year-old multiparous postmenopausal woman who presented to the Hakeem Abdul Hameed Centenary Hospital, New Delhi, India, in May 2014 with a lower abdominal swelling corresponding in size to a pregnancy of 26 gestational weeks and vaginal discharge of one year's duration. A total abdominal hysterectomy with a bilateral salpingooophorectomy was performed, which revealed an enlarged uterus with pyometra. Histopathology showed that the entire endometrial lining had been replaced with malignant squamous cells without invasion of the myometrium. Immunohistochemistry revealed that the tumour cells were positive for p63 with a high Ki-67 labelling index. No adjuvant therapy was required and the patient was disease-free at a seven-month follow-up.

show abstract

The Occurrence of Squamous Epithelium in the Endometrium

Cited by 68 publications

References 0 publications

Primary Endometrial Squamous Cell Carcinoma: A Case Report and Review of Relevant Literature on Korean Women

Primary Endometrial Squamous Cell Carcinoma: A Case Report and Review of Relevant Literature on Korean Women

Endometrial metaplasias and reactive changes: a spectrum of altered differentiation

Primary Endometrial Squamous Cell Carcinoma In Situ: Report of a rare disease

Contact Info

Product

Resources

About