The Occurrence of Sleep‐Disordered Breathing Among Patients With Head and Neck Cancer

Friedman, Michael; Landsberg, Roee; Pryor, Shepherd; Syed, Zubair; Ibrahim, Hani; Caldarelli, David D.

doi:10.1097/00005537-200111000-00008

Cited by 74 publications

(98 citation statements)

References 14 publications

(16 reference statements)

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“…Moreover when upper airway obstruction is due to epiglottis collapse (lax epiglottis is very common in irradiated patients), positive pressure may exacerbate upper Our patients were affected by severe OSAS due to epiglottis collapse. In case of OSAS due to epiglottis collapse the management can be surgical and consists of laser assisted or robotic epiglottectomy but patients with head and neck cancer are not likely to be candidates for upper airway surgery because of the risk of poor wound healing and swallowing disfunction [1].…”

Section: Discussionmentioning

confidence: 99%

“…The intermittent hypoxia, consequent to obstruction, and the sleep fragmentation lead to an increased cardiovascular risk and daytime sleepiness. Some authors reported a high prevalence of OSAS in patients treated for head and neck cancer, underlining the importance to screen them to increase their quality of life [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, most of patients included in these studies (67 %) discontinued use of Continuous Positive Airway Pressure (CPAP), due to pain and xerostomia, secondary to treatment [1]. We describe two cases of severe OSAS induced by surgery and radiotherapy, treated by Mandibular Advancing Devices (MADs).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Two Cases of Severe Obstructive Sleep Apnea Induced by Neck Radiotherapy Treated with an Oral Device

Piccin

Sorrenti

Milano

2015

J. Maxillofac. Oral Surg.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Two Cases of Severe Obstructive Sleep Apnea Induced by Neck Radiotherapy Treated with an Oral Device

Piccin

Sorrenti

Milano

2015

J. Maxillofac. Oral Surg.

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“…Several small case series have described an increased risk of OSA in patients with squamous cell head and neck cancers. Using polysomnography (PSG) as the gold standard, these reports describe an incidence of OSA ranging from 8% to 92% [7,[15][16][17][18]. Only one study was in a pretreatment group, and the rest were in head and neck cancer patients posttreatment (radiation or surgery).…”

Section: Introductionmentioning

confidence: 99%

Sleep-Related Breathing Disorders in Patients With Tumors in the Head and Neck Region

Faiz

Balachandran

Hessel³

et al. 2014

The Oncologist

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Background. Sleep disturbance is a prominent complaint of cancer patients. Most studies have focused on insomnia and cancer-related fatigue. Obstructive sleep apnea (OSA) has been reported in small studies and case reports. Methods. In a retrospective review of patients who underwent formal sleep evaluation and polysomnography (PSG) from 2006 to 2011, 56 patients with tumors in the head and neck region were identified. Clinical characteristics, sleep-related history, and PSG data were reviewed. Results. Most patients had active cancer (80%), and the majority had squamous pathology (68%). Prominent symptoms included daytime fatigue (93%), daytime sleepiness (89%), and snoring (82%). Comorbid conditions primarily included hypertension (46%) and hypothyroidism (34%). Significant sleeprelated breathing disorder was noted in 93% of patients, and 84% met clinical criteria for OSA. A male predominance (77%) was noted, and patients were not obese (body mass index ,30 kg/m 2 in 52%).The majority of patients (79%) underwent radiation prior to sleep study, of which 88% had OSA, and in the

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“…53 Head and neck cancer patients may also have sleep problems related to difficulty with oral secretions, dysphagia, cough, aspiration, xerostomia, pain, and sleep apnea. 54 Our prior work has shown that poor sleep is correlated with nicotine use and low physical activity, which may confound the analyses. Behavioral and pharmaceutical interventions may help head and neck cancer patients improve their sleep; however, the underlying causes of insomnia should first be assessed and treated.…”

mentioning

confidence: 99%

Pretreatment Health Behaviors Predict Survival Among Patients With Head and Neck Squamous Cell Carcinoma

Duffy

Ronis

McLean

et al. 2009

JCO

138

150

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A B S T R A C T PurposeOur prior work has shown that the health behaviors of head and neck cancer patients are interrelated and are associated with quality of life; however, other than smoking, the relationship between health behaviors and survival is unclear. Patients and MethodsA prospective cohort study was conducted to determine the relationship between five pretreatment health behaviors (smoking, alcohol, diet, physical activity, and sleep) and all-cause survival among 504 head and neck cancer patients. ResultsSmoking status was the strongest predictor of survival, with both current smokers (hazard ratio [HR] ϭ 2.4; 95% CI, 1.3 to 4.4) and former smokers (HR ϭ 2.0; 95% CI, 1.2 to 3.5) showing significant associations with poor survival. Problem drinking was associated with survival in the univariate analysis (HR ϭ 1.4; 95% CI, 1.0 to 2.0) but lost significance when controlling for other factors. Low fruit intake was negatively associated with survival in the univariate analysis only (HR ϭ 1.6; 95% CI, 1.1 to 2.1), whereas vegetable intake was not significant in either univariate or multivariate analyses. Although physical activity was associated with survival in the univariate analysis (HR ϭ 0.95; 95% CI, 0.93 to 0.97), it was not significant in the multivariate model. Sleep was not significantly associated with survival in either univariate or multivariate analysis. Control variables that were also independently associated with survival in the multivariate analysis were age, education, tumor site, cancer stage, and surgical treatment. ConclusionVariation in selected pretreatment health behaviors (eg, smoking, fruit intake, and physical activity) in this population is associated with variation in survival.

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The Occurrence of Sleep‐Disordered Breathing Among Patients With Head and Neck Cancer

Abstract: Identification and treatment of OSA may be an important factor in improving quality of life for patients with head and neck cancer.

Cited by 74 publications

References 14 publications

Two Cases of Severe Obstructive Sleep Apnea Induced by Neck Radiotherapy Treated with an Oral Device

Two Cases of Severe Obstructive Sleep Apnea Induced by Neck Radiotherapy Treated with an Oral Device

Sleep-Related Breathing Disorders in Patients With Tumors in the Head and Neck Region

Pretreatment Health Behaviors Predict Survival Among Patients With Head and Neck Squamous Cell Carcinoma

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