“…For example, as shown in Table 1, the maximum concentration (c max ) of roxithromycin (RTM) was up to 630 ng L − 1 in Bohai Bay (Zou et al, 2011) of the of sulfamethoxazole (SMX) was up to 77 ng L − 1 in Liaodong Bay of the BS, the c max of dehydrated erythromycin (ETM-H 2 O) was up to 1730 ng L − 1 in Victoria Harbour of Hong Kong, China (Minh et al, 2009), the c max of SMX was up to 43 ng L − 1 in Belgian coastal harbours (Wille et al, 2010), and so on. However, the most recent studies mainly pay attention to semi-enclosed areas with poor water-exchange ability, such as the coastal areas of the three main bays (Bohai Bay, Laizhou Bay and Liaodong Bay) of the BS Zhang et al, 2012b;Zou et al, 2011) and Victoria Harbour of Hong Kong (Gulkowska et al, 2007;Minh et al, 2009;Xu et al, 2007b). Limited information is available regarding the presence of antibiotics in open coastal areas, which usually have stronger water-exchange ability and less serious pollution than semi-enclosed areas.…”