The occurrence of sacroiliitis in HLA-B*35-positive patients with undifferentiated spondyloarthritis. A cross sectional MRI study

Šošo, Daniela; Aljinović, Jure; Marinović, Ivanka; Kojundžić, Sanja Lovrić; Jeličić, Esma Čečuk; Krstulović, Daniela Marasović

doi:10.1007/s10067-020-04999-4

Cited by 4 publications

(7 citation statements)

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“…On the other hand, in our study [30] some HLA-B*35 patients complained of pain and swelling of the joints and tendons or these symptoms were detected by a physician during a clinical examination. We found that the HLA-B*35 allele was associated with a five-fold greater chance of finding peripheral joint synovitis in un-axSpa patients.…”

Section: Introductioncontrasting

confidence: 50%

“…Given that we also noticed an increased frequency of the HLA-B*35 allele in patients with symptoms of axSpA and without any other known cause of axSpA, we conducted a study in which we confirmed the connection between sacroiliitis detected by MRI and the HLA-B*35 allele in patients with un-axSpA [30].…”

Section: Introductionmentioning

confidence: 65%

“…The association between HLA-B*35 allele and SpA, whether in the axial or the peripheral form of the disease, has long been known [20][21][22][23][24][25][26][31][32][33]. Indeed, in our study, a large proportion of the HLA-B*35 positive patients with preliminary diagnosis of un-axSpA had joint and tendon pain and swelling according to patients or their physicians [30], which we evaluated by US. In current practice in rheumatology, US is used to evaluate peripheral joint and periarticular abnormalities, whether to confirm or refute them [40] or to detect their subclinical presence, which would otherwise be missed on examination [41].…”

Section: Discussionmentioning

confidence: 86%

“…US was performed in 72 HLA-B*35 positive patients with preliminary diagnosis of un-axSpA and joint and tendon problems. These patients were part of our cross-sectional study that showed an association between sacroiliitis detected by MRI and HLA-B*35 allele after patients with HLA-B*27 allele, psoriasis, IBD, preceding infections and juvenile SpA were excluded [30]. Detailed history taking and additional laboratory analysis were performed to rule out other types of arthritis.…”

Section: Methodsmentioning

confidence: 99%

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Ultrasound-Verified Peripheral Arthritis in Patients with HLA-B*35 Positive Spondyloarthritis

Šošo

Aljinović

Kojundžić

et al. 2021

Life

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Background: We aimed to investigate possible association between the HLA-B*35 allele and peripheral arthritis, tenosynovitis and enthesitis. Methods: Ultrasound of peripheral joints and tendons was performed in 72 HLA-B*35 positive patients with preliminary diagnosis of undifferentiated axial form of spondyloarthitis and joint and tendon pain. Patients with other known types of axial and peripheral spondyloarthritis were excluded as well as patients with other known types of arthritis. Results: Pathological changes were found in the joints of 33 (46%) patients and on the tendons in 13 (18%) patients. The most common ultrasound findings were joint effusion and synovial proliferation with positive power Doppler signal grade 1. The most common ultrasound finding in patients with painful tendons was tenosynovitis. A higher disease activity and an increased incidence of elevated CRP (≥5 mg/L) were more often observed in the group with positive ultrasound findings. Conclusion: In this study, we showed that the HLA-B*35 allele could be a potential risk factor for developing peripheral arthritis, but not for tenosynovits and enthesitis in patients with the undifferentiated axial form of spondyloarthritis. This result may influence the follow up of these patients, especially since it gives us an opportunity to consider the use of different types of DMARDs in the treatment of these patients.

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Section: Introductioncontrasting

confidence: 50%

Section: Introductionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

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Ultrasound-Verified Peripheral Arthritis in Patients with HLA-B*35 Positive Spondyloarthritis

Šošo

Aljinović

Kojundžić

et al. 2021

Life

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“…ere are currently 86 polypeptide isoforms and 97 nucleotide variants present in this group [25]. Apart from its well-established association with the accelerated progression of HIV infection to AIDS, HLA-B * 35 has been reported to be associated with Juvenile idiopathic arthritis-related uveitis, self-limiting unclassified rheumatism, sacroiliitis in undifferentiated spondyloarthropathy, and oral aphthosis [26][27][28][29][30][31][32]. e literature on ocular involvement in HLA-B * 35 positivity is scarce and shows its presence in up to 24% of uveitis patients in a small-sized prospective study [33].…”

Section: Discussionmentioning

confidence: 99%

Describing the Clinical and Laboratory Features and HLA-B Pattern of Adult-Onset Idiopathic Autoimmune Uveitis at a Tertiary Hospital in South India: A Cross-Sectional Study

Visalakshy

Surendran

Ganu

et al. 2022

The Scientific World Journal

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Introduction. There is a scarcity of information available on clinical and laboratory features of adult-onset idiopathic autoimmune uveitis. Therefore, we conducted a single centre descriptive cross-sectional study. Patients and Methods. A chart review of all patients with idiopathic autoimmune uveitis with onset after 18 years of age who were referred to the rheumatology department between January 2017 and December 2018 was performed. Their clinical features, demographic features, and HLA-B genotypes were documented and described. Results. Out of 210 patients referred to rheumatology, 66 were found to have uveitis, and 16 of these had an adult-onset idiopathic autoimmune uveitis. Apart from a slight female preponderance (62.5%), our patients were characterized by a high proportion of panuveitis (4 out of 16, i.e., 25%). There was an increased frequency of occurrence of synechiae (5 out of 16, i.e., 31.3%), retinal vasculitis (4 out of 16, i.e., 25%), optic disc edema (3 out of 16, i.e., 18.8%), and cystoid macular edema (seen in 2 patients, i.e., 12.5%). These features correlated with the anatomical subtypes. Retinal vasculitis and optic disc edema present in three fourth of all panuveitis cases were the most prominent features. The odds of finding HLA-B∗35 in retinal vasculitis were 33 times higher than odds of finding it in idiopathic autoimmune uveitis patients not having retinal vasculitis (OR 33; 95% CI 1.6–698). Conclusion. Idiopathic autoimmune uveitis in our patients is characterized by a high frequency of panuveitis and retinal vasculitis, and complications with a probable association between HLA-B∗35 and retinal vasculitis.

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Human Leukocyte Antigen B*27-Negative Spondyloarthritis: Clinical, Serological, and Radiological Features of a Single-Center Cohort

Mariani,

Alunno,

Di Ruscio

et al. 2023

Diagnostics

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The strong genetic association between HLA-B*27 and spondyloarthritis (SpA) accounts for about 90% of the susceptibility to axial SpA (axSpA), and the presence of HLA-B*27 is helpful in classifying patients according to the Assessment of SpondyloArthritis International Society (ASAS) classification criteria. However, over the years, other HLA-B alleles have been associated with an increased risk of developing SpA; on this basis, the aim of our study was to describe the demographic, clinical, and radiological characteristics of a cohort of SpA patients who were negative for HLA-B*27. We identified 85 patients with a clinical diagnosis of SpA displaying HLA-B alleles other than HLA-B*27; HLA-B*51 emerged as the most prevalent allele (N = 33, 39%), regardless of the fulfilment of either the axial or the peripheral ASAS criteria. The second most prevalent allele in the full cohort (N = 16, 19%) and in the patients fulfilling either the axial or the peripheral criteria was HLA-B*35. The third most prevalent allele in the full cohort was HLA-B*18 (N = 12, 15%), which was also the second most prevalent allele in the patients fulfilling neither of the two sets of criteria. Overall, the clinical picture was similar across the subgroups fulfilling the different sets of ASAS criteria; however, the patients not fulfilling any ASAS criteria had a higher likelihood of having arthritis compared to the patients fulfilling the axial criteria, whereas the Bath Ankylosing Spondylitis Functional Index was significantly higher in those patients fulfilling the axial criteria compared to those who did not fulfill any criteria. Our results indicate that other HLA alleles, beyond HLA-B*27, could be useful in facilitating SpA diagnosis, particularly in patients with a clinical picture which is consistent with SpA but does not fulfill the ASAS classification criteria.

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The occurrence of sacroiliitis in HLA-B*35-positive patients with undifferentiated spondyloarthritis. A cross sectional MRI study

Cited by 4 publications

References 42 publications

Ultrasound-Verified Peripheral Arthritis in Patients with HLA-B*35 Positive Spondyloarthritis

Ultrasound-Verified Peripheral Arthritis in Patients with HLA-B*35 Positive Spondyloarthritis

Describing the Clinical and Laboratory Features and HLA-B Pattern of Adult-Onset Idiopathic Autoimmune Uveitis at a Tertiary Hospital in South India: A Cross-Sectional Study

Human Leukocyte Antigen B*27-Negative Spondyloarthritis: Clinical, Serological, and Radiological Features of a Single-Center Cohort

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