The occurrence of osteosarcoma after tibial fracture repair in a dog

Isaka, Mitsuhiro; Kokubo, Daiki; Sakai, Toshikazu

doi:10.4314/ovj.v11i1.3

Cited by 6 publications

(3 citation statements)

References 11 publications

(17 reference statements)

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“…reports describe an OS developing 6 years after a TPLO procedure 26 ; a Cane Corso is reported to have OS arising 6 years after a tibial tuberosity advancement 31 ; and in a Labrador Retriever 12 years after tibial fracture repair. 32 This latter dog died 1 month following amputation of the tumourcontaining limb. 32 Fracture-induced or metallic implantassociated OS specifically developing around the TPLO plate has a median occurrence of 2 to 4 years following the procedure.…”

Section: Discussionmentioning

confidence: 97%

“…32 This latter dog died 1 month following amputation of the tumourcontaining limb. 32 Fracture-induced or metallic implantassociated OS specifically developing around the TPLO plate has a median occurrence of 2 to 4 years following the procedure. 30 Factors possibly promoting the development of fracture-related sarcomas include patient sensitivity to the implant, implant corrosion, instability of the fracture or inappropriate bone healing.…”

Section: Discussionmentioning

confidence: 97%

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Spontaneous Regression and Reoccurrence of Osteosarcoma in a Canine Tibia

Obringer

Coolman

Crawford³

2021

VCOT Open

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A 32-month-old female Labrador Retriever mix-breed presented for right pelvic limb lameness with firm swelling on the lateral aspect of the stifle. Radiographs revealed a mass with periosteal elevation along the lateral cortex of the proximal tibia. Histology on a core biopsy sample was diagnostic for osteosarcoma. Surgical treatment was declined. Eight months post diagnosis, the patient was re-evaluated by the primary care veterinarian and had no lameness, pain, or tibial swelling. Sixty-three months later (5.2 years), the patient presented for cranial cruciate ligament ruptures. Radiographs revealed a smooth bony protuberance on the lateral aspect of the right proximal tibia in the area of the previous osteosarcoma. The patient underwent bilateral tibial plateau levelling osteotomies. The surgical recovery was uneventful with normal healing. Twenty-seven months following surgery, the patient returned for painful swelling around the right proximolateral tibia. Radiographs revealed an 8 × 9 cm osteoproliferative and osteolytic lesion of the proximal tibia. Osteosarcoma was confirmed via core biopsy. The bone tumour grew rapidly, and the patient was euthanatized 3 months thereafter. This case report demonstrates the unusual occurrence of an osteosarcoma in a young dog which spontaneously regressed. Ninety months (7.5 years) after clinical resolution of the initial tumour, osteosarcoma formed again in the same location. Lifetime patient monitoring with repeated clinical exams, serial radiographs, and multiple biopsies by the same surgeon, pathologists, and radiologist are unique features of this case report.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Spontaneous Regression and Reoccurrence of Osteosarcoma in a Canine Tibia

Obringer

Coolman

Crawford³

2021

VCOT Open

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“…True incidence of STS in dogs is unknown but it has been previously suggested that these tumours account for 9%–15% of all cutaneous and subcutaneous canine tumours 1 . The underlying causes for sarcomas are varied and multifactorial 2–28 . In dogs, STS have been associated with radiation, trauma, chronic inflammation and parasitic infection 2–6 .…”

Section: Introductionmentioning

confidence: 99%

Outcome with surgical treatment of canine soft tissue sarcoma in the region of the ischiatic tuberosity: A veterinary society of surgical oncology retrospective study

Paulos

Boston

Skinner

et al. 2022

Vet Comparative Oncology

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The aim of this study was to determine the outcome of dogs with soft tissue sarcoma (STS) within the region of the ischiatic tuberosity (ITSTS) treated surgically. This was a multi‐institutional retrospective study. Fifty‐two dogs met the inclusion criteria, which were: histologically confirmed STS in the region of the IT treated with surgical resection between March 1st, 2009 and March 1st, 2021 with a minimum follow‐up time of 6 months. Data collected included patient signalment, preoperative diagnostics, surgical intent/method, surgical complications, histopathology, margins, outcome and cause of death. Statistical analyses were performed to determine significant factors in the treatment and prognosis of ITSTS. Overall survival time (OST) and disease progression were negatively associated with tumour grade, while recurrence was positively associated with grade and incomplete margins. Of the 52 included dogs, there were 24 grade I, 20 grade II and 7 grade III tumours. Forty dogs had reported histopathologic margins of which 26 were reported to be complete and 14 were incomplete. OST and progression‐free survival was not reached for tumours graded as I or II and was 255 and 268 days respectively, for grade III. Median time to recurrence was not reached for tumours excised with complete margins and was 398 days for those with incomplete margins. The surgical complication rate was 25%. ITSTS was not found to be a unique clinical entity in dogs as tumour behavior, treatment recommendations, and prognosis were similar to STS in other locations, with overall outcome and prognosis influenced by histologic grade and margins. While surgical complications were common, none resulted in significant morbidity or mortality.

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