18 ground sections, one each from the same number of fluorosed human deciduous teeth, were screened by transmitted light microscopy for the presence of inhomogenous areas in the outer region of the enamel. Ground sections as well as broken surfaces from five of these teeth were then also studied by scanning electron microscopy, with and without in vitro etching. In unetched material, the results showed the anatomical surface of the teeth to be smooth, pitted or very rough. The latter types frequently showed irregular elevations above the surface plane. In the subsurface part, the inhomogenous regions displayed an outer area of a sintered texture with barely visible prismatic markings, but sometimes showing a layered appearance parallel to the anatomical surface. Deeper areas showed clearly identifiable, and sometimes markedly hollowed-out, prisms. The altered outer regions were, in comparison with nonaltered outer regions, found to be relatively resistant to in vitro acid etching. These observations are interpreted as mainly reflecting post-formative changes, linked with decalcification and recalcification, and they are briefly discussed in relation to caries susceptibility.