The occurrence of infective endocarditis with Staphylococcus lugdunensis bacteremia: A retrospective cohort study and systematic review

Non, Lemuel; Santos, Carlos

doi:10.1016/j.jinf.2016.10.003

Cited by 39 publications

(41 citation statements)

References 31 publications

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“…Staphylococcus lugdunensis is responsible for infections ranging from minor skin and soft tissue infections (Bocher et al, 2009; Arias et al, 2010) to invasive diseases such as infective endocarditis (Non and Santos, 2017), bone and joint infections (Douiri et al, 2016; Lourtet-Hascoët et al, 2016; Argemi et al, 2017a), prosthetic device-infections (Anguera, 2005; Shah et al, 2010) and vascular catheter-related infections (Ebright et al, 2004), both in healthy host and immune-compromised patients. One of the characteristics of S. lugdunensis infections is the development of deep-seated abscess lesions that cannot be cleared without surgical intervention associated with effective antibiotic therapy (Arias et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Comparative Genome Analysis of Staphylococcus lugdunensis Shows Clonal Complex-Dependent Diversity of the Putative Virulence Factor, ess/Type VII Locus

et al. 2019

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Staphylococcus lugdunensis is a commensal bacterium of human skin that has emerged as a virulent Coagulase-Negative Staphylococcus in both community-acquired and healthcare associated infections. Genotyping methods have shown a clonal population structure of this pathogen but failed to identify hypervirulent lineages. Here, complete genomes of three pathogenic and three carriage S. lugdunensis strains were obtained by Single-Molecule sequencing (PacBio) and compared to 15 complete genomes available in GenBank database. The aim was to identify (i) genetic determinants specific to pathogenic or carriage strains or specific to clonal complexes (CCs) defined by MultiLocus Sequence Typing, and (ii) antibiotic resistance genes and new putative virulence factors encoded or not by mobile genetic elements (MGE). Comparative genomic analysis did not show a strict correlation between gene content and the ability of the six strains to cause infections in humans and in a Galleria mellonella infection model. However, this study identified new MGEs (five prophages, two genomic islands and one plasmid) and genetic variations of some putative virulence-associated loci, especially in CC3 strains. For a clonal population, high variability and eight CC-dependent genetic organizations were observed for the ess locus, which encodes a putative type VII secretion system (T7SS) homologous to that of S. aureus. Further phenotypic and functional studies are needed to characterize this particular CC3 and to evaluate the role of T7SS in the virulence of S. lugdunensis.

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Section: Introductionmentioning

confidence: 99%

Comparative Genome Analysis of Staphylococcus lugdunensis Shows Clonal Complex-Dependent Diversity of the Putative Virulence Factor, ess/Type VII Locus

et al. 2019

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“…Clinically significant bacteremia was established in 2 patients and was treated; blood contamination with S. lugdunensis was diagnosed in the other two patients. Even though S. lugdunensis is a part of the normal skin flora and its isolation in blood cultures can represent contamination, the detection of this organism even in a single blood culture should be thoroughly evaluated as S. lugdunensis bacteremia can be associated with an aggressive infection such as endocarditis [31314]. A small study by Fadel et al found that clinically significant bacteremia occurred in 16 out of 29 (45%) patients with single S. lugdunensis -positive blood cultures [15].…”

Section: Discussionmentioning

confidence: 99%

A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States

et al. 2019

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Background Staphylococcus lugdunensis is a coagulase-negative staphylococcus (CoNS) that is a part of the normal human skin flora. Even though it belongs to CoNS family, it can cause severe and destructive infections in a similar fashion to Staphylococcus aureus . Skin and soft tissue infections (SSTI), bacteremia and endocarditis are amongst the most common clinical presentations. Diagnosis and clinical presentation of infections caused by S. lugdunensis in cancer patients is limited. Materials and Methods We performed a retrospective chart review of 24 patients who had cultures positive for S. lugdunensis . Out of 24 patients, 14 patients were diagnosed with a true infection and 10 other patients were considered to be colonized with this pathogen. We analyzed clinical manifestation, treatment and response to therapy. Results SSTI was the most common presentation in our study patients. All patients diagnosed with SSTI had a prior surgery or an invasive procedure at the affected site. Five urinary tract infections (UTIs), one catheter-associated bloodstream infection, and a deep pelvic abscess were other reported infections in our study. We observed that S. lugdunensis remains susceptible to a variety of antibiotics, with all isolates susceptible to vancomycin and linezolid and most remain susceptible to fluoroquinolone and trimethoprim/ sulfamethoxazole. All 14 patients received antibiotics and improved. Conclusion In our case series, SSTI was common and diagnosed in 50% of the patients with clinically significant isolates for S. lugdunensis . This is consistent with prior studies indicating that S. lugdunensis is a significant pathogen in SSTIs. UTI was the second most common infection type in our patient population.

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“…A series of cases of infective endocarditis among patients with S. lugdunensis bacteraemia was recently reported in this journal by Non et al. 1 In addition to other reports of endocarditis, 2 , 3 , 4 this organism has also increasingly been recognized in association with invasive infections at other sites including those arising in an orthopaedic setting. 5 , 6 A recent retrospective study of prosthetic joint infections (PJI) in France found that S. lugdunensis may result in less favourable outcomes than other CoNS, with reported outcomes similar to S. aureus .…”

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confidence: 88%

Metalware-associated orthopaedic infections caused by Staphylococcus lugdunensis : An emerging pathogen

Gow

Atkins

et al. 2017

Journal of Infection

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The occurrence of infective endocarditis with Staphylococcus lugdunensis bacteremia: A retrospective cohort study and systematic review

Cited by 39 publications

References 31 publications

Comparative Genome Analysis of Staphylococcus lugdunensis Shows Clonal Complex-Dependent Diversity of the Putative Virulence Factor, ess/Type VII Locus

Comparative Genome Analysis of Staphylococcus lugdunensis Shows Clonal Complex-Dependent Diversity of the Putative Virulence Factor, ess/Type VII Locus

A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States

Metalware-associated orthopaedic infections caused by Staphylococcus lugdunensis : An emerging pathogen

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