The occurrence of IgM and complement factors along myelin sheaths of peripheral nerves An immunohistochemical study of the Guillain-Barré syndrome

Luijten, J.A.F.M.; Faille-Kuyper, Eva H. Baart de la

doi:10.1016/0022-510x(72)90009-3

Cited by 68 publications

(8 citation statements)

References 3 publications

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“…This finding could be related to an abnormal permeability of the nerve blood vessels [13] as already shown in EAN, the animal model for Guillain-Barr6 polyradiculoneu ropathy [16]. As a matter of fact, according to other authors, just in 50-60% of AIDP cases immunoglobulins are found on the myelinated fibers [10,13]. DIF in vas culitis-associated neuropathies demonstrated mainly fi brinogen deposits within the epineurial and endoneurial vessels.…”

Section: Discussionmentioning

confidence: 90%

“…Immunoglobulins and complement deposits in pe ripheral nerves were previously reported in a number of polyneuropathies [9,13,23], Immunoglobulins were demonstrated by immunofluorescence techniques in neuropathies associated with paraproteinemia [1,5,12,19,21,22], diabetic neuropathy [4], paraneoplastic neu ropathy [17], acute inflammatory demyelinating polyra diculoneuropathy (AIDP) [10,14], chronic inflamma tory demyelinating polyradiculoneuropathy (CIDP) [3], in a wide variety of hereditary neurological disorders, collagen vascular diseases, toxic neuropathies and even in human nonpathological nerves [23].…”

Section: Introductionmentioning

confidence: 99%

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Direct Immunofluorescence in Sural Nerve Biopsies

Schenone

Martini²,

Tabaton³

et al. 1988

Eur Neurol

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Direct immunofluorescence (DIF) has been carried out in 66 sural nerve biopsies using antibodies against human IgG, IgA, IgM, C3, C4, albumin, fibrinogen, and ĸ- and λ-chains. In 37 out of 63 (59%) different neuropathies immunoglobulins or other plasma proteins were found within the peripheral nerves. IgM along the myelin sheaths were found in monoclonal IgM-K-associated demyelinating peripheral neuropathy and chronic inflammatory demyelinating peripheral neuropathy. IgM within the perineurium were detected in hereditary, diabetic, paraneoplastic, paraproteinemic and neuropathies of unknown cause. In inflammatory, vasculitic, hereditary and toxic neuropathies fibrinogen, albumin, IgG and IgA were variably observed in endoneurium, endoneurial vessels, perineurium and epineurial vessels. In our experience DIF appears to be just an unspecific marker of sural nerve pathology. In selected cases however DIF may be helpful in the diagnosis or in better understanding the pathogenetic mechanisms of the disease.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Direct Immunofluorescence in Sural Nerve Biopsies

Schenone

Martini²,

Tabaton³

et al. 1988

Eur Neurol

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“…Several other observations regarding the association of autoantibodies and GBS are noteworthy. (I) Some authors described deposits of IgM and IgG in peripheral nerve tis sue fibers [11,38], while others [39,40] failed to observe similar findings. (2) No class switching from IgM to IgG was observed [29] in myelin autoantibodies, to mark the possible generation o f an immunologic memory.…”

Section: Autoantibodiesmentioning

confidence: 85%

Guillain-Barré as an Autoimmune Disease

Shoenfeld

George²,

Peter³

1996

Int Arch Allergy Immunol

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Guillain-Barré syndrome (GBS) entails a demyelinating process of the peripheral nervous system. The etiopathogenesis of the syndrome is still a matter of debate although considerable progress has been accomplished in the recent years. Abundant evidence has been put forward so as to support the role of the immune system in initiating and perpetuating the ongoing damage culminating in the emergence of the clinically overt syndrome. As such, data on the involvement of the humoral immune pathways add to the information already presented with regard to cell-mediated mechanisms participating in disruption of peripheral nerve. The following review will focus on the current knowledge of these complex mechanisms and the relative significance of each in the pathogenesis of GBS.

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“…A nerve from one of the patients (case 4) with chronic Guillain-Barre syndrome (see Luitjen and Baart de la Faille-Kuyper, 1972), and the nerve from case 5, with an axonal neuropathy, both showed affinity for the monoclonal IgM-Kappa in case I serum. The other cases, and a normal nerve, as also shown by Propp et al (1975), showed no such affinity.…”

Section: Discussionmentioning

confidence: 98%