The Occurrence of Antibody Markers of Hepatitis B Virus Infection in an HBsAg‐Negative Blood Donor Population

Katchaki, J. N.; Waart, M. van der; Siem, T. H.; Brouwer, R.; Schuurs, A.H.W.M.

doi:10.1111/j.1423-0410.1979.tb02262.x

Cited by 10 publications

(4 citation statements)

References 14 publications

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“…In addition, all sera containing anti-HBs but no anti-HBc, and most sera positive for anti-HBc but negative for anti-HBs, contained no anti-HBe. This is in agreement with the limited data presented by Katchaki et al [15] and Frosner et al [7].…”

Section: Discussionsupporting

confidence: 94%

“…It remains to be determined whether or not the above situations correlate with the presence of anti-HBe. The occurrence of anti-HBe in the absence of other HBV markers has been previously demonstrated [15]. In the present study, 2 of 485 individuals negative for HBsAg, anti-HBs and anti-HBc were posi-tive for anti-HBe.…”

Section: Discussionsupporting

confidence: 75%

“…So far, the duration of the anti-HBe response after HBV infection has not been studied. Very limited data suggest that determination of anti-HBe may help to discriminate between different states of HBV infection in HBsAg-negative individuals [5,7,15]. The present paper reports on the incidence of anti-HBe in HBsAg-negative individuals and discusses its significance to differentiate various states of HBV infection.…”

mentioning

confidence: 84%

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Significance of Antibody to Hepatitis Be Antigen (Anti-HBe) in HBsAg-Negative Individuals

Hess¹,

Arnold²,

Gahl³

et al. 1981

Vox Sanguinis

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A study was initiated to assess the significance of antibody to hepatitis B e antigen (anti-HBe) in HBsAg-negative individuals. Anti-HBe was demonstrated in the majority of sera positive for anti-HBs and anti-HBe. All sera positive for anti-HBs and negative for anti-HBe and most sera positive for anti-HBe but negative for anti-HBs were anti-HBe-negative. This implies that the antibody response to HBeAg is of shorter duration than that to HBsAg and HBeAg. Anti-HBe may help to discriminate between various states of hepatitis B virus infection found to be associated with anti-HBc-positive but HBsAg- and anti-HBs-negative sera. 2 individuals were anti-HBe-positive but HBsAg-, anti-HBs- and anti-HBc-negative, this finding is not understood.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 75%

mentioning

confidence: 84%

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Significance of Antibody to Hepatitis Be Antigen (Anti-HBe) in HBsAg-Negative Individuals

Hess¹,

Arnold²,

Gahl³

et al. 1981

Vox Sanguinis

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“…The transfusion of blood containing anti-HBs is reported to be no more likely to transmit hepatitis B than blood which is negative for HBsAg and anti-HBS [6,7], and it, therefore, seems reasona ble that donors who are transiently positive for HBsAg and go on to produce anti-HBs are reinstated as acceptable blood donors. Knowing the reward in terms of donors re stored to the active panel could quite possi bly have a bearing on the effort put into the follow-up of HBsAg-reactive donors.…”

Section: Introductionmentioning

confidence: 99%

Frequency and Persistence of Serologic Markers Following Three Different Manifestations of Hepatitis B Virus Infection

Wilkinson¹

1983

Vox Sanguinis

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30 asymptomatic chronic carriers of hepatitis B surface antigen (HB(s)Ag), 6 asymptomatic blood donors transiently infected with hepatitis B virus, and 38 patients with acute hepatitis B were tested for HB(s)Ag, anti-HB(s), HB(e)Ag, anti-HB(e) and anti-HB(c). Comparison of these results revealed significant variation in the frequency of HB(e)Ag which was present in 1 (3.3%) carrier, 2 (33.3%) of the transiently positive donors, and in 24 (63.2%) of the patients with acute hepatitis. Anti-HB(e) was found in 28 (93.3%) of the carriers, 4 (66.6%) of the transiently positive donors, and in 8 (21%) of the patients. Variation was also seen in the strength of anti-HB(c), with only the chronic carriers having titres which were consistently high (above 1,000). Retesting the two groups of donors after a period of approximately 2 years showed no change in the serologic status of the chronic carriers, while amongst the transient HB(s)Ag positives the 2 HB(e)Ag reactives had seroconverted, 1 of the anti-HB(e) positives had become non-reactive, and 2 of the 6 had developed anti-HB(s). 6 of the patients with acute hepatitis B were serologically reexamined during convalescence and showed results similar to those seen in the transiently HB(s)Ag-positive donors, with clearance of HB(s)Ag in all, seroconversion from HB(e)Ag to anti-HB(e) in 4, and the production of anti-HB(s) in 4.

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Contrasting patterns and frequency of antibodies to the surface, core, and e antigens of hepatitis b virus in blood donors and in homosexual patients

Tedder

Cameron

Wilson-Croome

et al. 1980

Journal of Medical Virology

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An attempt was made to assess the significance of the relatively frequent low-titre positive reactions in radioimmunoassays for antibody to hepatitis B surface antigen. Serum specimens negative for surface antigen were assayed for antibodies to the surface, core, and e antigens of the Hepatitis B virus. Two populations were studied - one of low hepatitis B incidence (2000 blood donors) and one of high incidence (200 male patients attending a clinic for sexually transmitted diseases). The validity of some singly occurring low-titre anti-HBs and anti-HBc reactions is questioned, and the occurrence of positive reactions unrelated to previous hepatitis B infection inferred.

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The Occurrence of Antibody Markers of Hepatitis B Virus Infection in an HBsAg‐Negative Blood Donor Population

Cited by 10 publications

References 14 publications

Significance of Antibody to Hepatitis Be Antigen (Anti-HBe) in HBsAg-Negative Individuals

Significance of Antibody to Hepatitis Be Antigen (Anti-HBe) in HBsAg-Negative Individuals

Frequency and Persistence of Serologic Markers Following Three Different Manifestations of Hepatitis B Virus Infection

Contrasting patterns and frequency of antibodies to the surface, core, and e antigens of hepatitis b virus in blood donors and in homosexual patients

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