The Occurence of Mood and Anxiety Disorders in Heart Transplant Recipients

Pudło, Robert; Piegza, Magdalena; Zakliczyńśki, Michał; Zembala, Michał

doi:10.1016/j.transproceed.2009.09.031

Cited by 20 publications

(8 citation statements)

References 15 publications

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“…[16][17][18][19][20]33 Items from published measures that were applicable to the post-heart transplant experience were selected or adapted as appropriate, and nine items were selected with responses on a 5-point Likert scale ranging from "never" (1) to "always" ( 5). An additional three items were included inquiring about understanding of complications of heart transplantation and discussing worries about complications with loved ones and healthcare team members with responses on a 5-point Likert scale ranging from "strongly disagree" (1) to "strongly agree" (5). All metric items were discussed with experts in medical management of pediatric heart transplantation as well as psychological care post pediatric heart transplantation.…”

Section: Measure Developmentmentioning

confidence: 99%

“…Transplantation also seeks to improve the health-related quality of life for pediatric patients with end-stage heart disease; however, a subset remains at risk for impaired psychological well-being following transplant, 3 as well as impaired health-related quality of life, neuropsychological outcomes, and family function as compared to non-transplant recipients. 4 While mental health disorders are well studied in adult patients after heart transplantation, [5][6][7] less is known about the long-term mental health of pediatric heart transplant recipients. [8][9][10] Limited studies suggest that pediatric heart transplant patients may have increased risk of psychological disorders when compared to the general population.…”

mentioning

confidence: 99%

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Generalized and specific anxiety in adolescents following heart transplant

McCormick

Schumacher

Zamberlan

et al. 2019

Pediatric Transplantation

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Despite advancements in medical and surgical management, heart transplantation is the only life-prolonging option for some pediatric patients with end-stage heart disease. According to data from the Pediatric Heart Transplant Study, the numbers of both listed and transplanted pediatric patients are slowly increasing, with improving post-transplant survival. 1 However, the risk of morbidity and death remain. For many pediatric patients and their caregivers, life postheart transplantation results in improved physical functioning, but also involves the management of a new chronic condition and the potential for complications such as infection, rejection, renal failure,

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Section: Measure Developmentmentioning

confidence: 99%

mentioning

confidence: 99%

Generalized and specific anxiety in adolescents following heart transplant

McCormick

Schumacher

Zamberlan

et al. 2019

Pediatric Transplantation

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show abstract

“…Compounding the concept of T‐cell‐dependent mood modulation, striking alterations in human behaviour can also be induced by a wide range of immunomodulatory drugs. Cyclosporine, a T‐cell‐directed immunosuppressive peptide widely used in organ transplantation, has been shown to induce a range of neuropsychological problems including depression and anxiety both in patients and in experimental animals . Chemotherapy also commonly causes acute psychological complications, too severe to be considered a reaction to the treatments physical effects alone …”

Section: Leucocytes Lymphocytes Cognition and Depression: The Immunmentioning

confidence: 99%

“…Cyclosporine, a T-cell-directed immunosuppressive peptide widely used in organ transplantation, has been shown to induce a range of neuropsychological problems including depression and anxiety both in patients and in experimental animals. [68][69][70] Chemotherapy also commonly causes acute psychological complications, too severe to be considered a reaction to the treatments physical effects alone. 71,72 While it seems clear that these cells have an influence on our emotional state, the key question that remains to be addressed is how and by what mechanisms?…”

Section: Leucocytes Lymphocytes Cognition and Depression: The Immunmentioning

confidence: 99%

‘As above, so below’ examining the interplay between emotion and the immune system

et al. 2014

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SummaryWhile the concept of a palpable relationship between our mental and physical well-being is certainly not new, it is only in the light of modern scientific research that we have begun to realize how deeply connected our emotional and immune states may be. We begin this review with a series of studies demonstrating how four fundamental emotional responses: anger, anxiety, mirth and relaxation are able modulate cytokine production and cellular responses to a variety of immune stimuli. These modulations are shown to be either detrimental or beneficial to a patient's health dependent on the context and duration of the emotion. We also discuss the reverse, highlighting research demonstrating how the loss of key immune cells such as T lymphocytes in clinical and animal studies can negatively impact both emotional well-being and cognition. Additionally, to give a more complete picture of the manifold pathways that link emotion and the immune system, we give a brief overview of the influence the digestive system has upon mental and immunological health. Finally, throughout this review we attempt to highlight the therapeutic potential of this burgeoning field of research in both the diagnosis and treatment of immune and disorders. As well as identifying some of the key obstacles the field must address in order to put this potential into practice.

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“…Thus, up to 40% -51% of post-transplant patients have any of these psychiatric disorders [6,7]. In contrast, mania appears not be that frequent in this adult population, with only 8% having a manic episode post-transplant, and additional 33% slightly elevated mood, highest within the first 3 weeks post-transplant [8]. Interestingly, the first onset of bipolar disorder has been documented as late as 5 years post-transplant [9].…”

Section: Introductionmentioning

confidence: 99%

Rapid cycling bipolar disorder post-heart transplant: A case report

Thompson¹,

Cosker²,

Body³

et al. 2018

Case Rep Imag Surg

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There are few reports of psychiatric complications following transplant surgery in older people. Here we present a longitudinal assessment of a 69-year-old lady, a carrier of Duchenne's muscular dystrophy, who after having a heart transplant developed transient and prolonged neurological and psychiatric features. Initially the presentation resembled steroid induced psychosis with an underlying delirium; however, this evolved into an episode of rapid cycling diurnal mood variation. The following admission was due to being mute and un-cooperative with a poor oral intake. She was admitted to hospital again following a grand-mal seizure and now experiencing previous symptoms of delirium (hallucinations, irritability, and aggression) and had some cognitive impairment with fronto-executive dysfunction, alongside rapid cycling diurnal mood. We believe this to be the first time a rapid-cycling bipolar disorder has been described in an older person post-heart transplant surgery.

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The Occurence of Mood and Anxiety Disorders in Heart Transplant Recipients

Cited by 20 publications

References 15 publications

Generalized and specific anxiety in adolescents following heart transplant

Generalized and specific anxiety in adolescents following heart transplant

‘As above, so below’ examining the interplay between emotion and the immune system

Rapid cycling bipolar disorder post-heart transplant: A case report

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