The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis

Angelova-Fischer, Irena; Bauer, Andrea S.; Hipler, Uta‐Christina; Petrov, Igor; Kazandjieva, Jana; Brückner, Thomas; Diepgen, Thomas L.; Tsankov, Nikolaï; Williams, Mary L.; Fischer, Tanja; Elsner, Peter; Fluhr, Joachim W.

doi:10.1111/j.1365-2133.2005.06697.x

Cited by 51 publications

(45 citation statements)

References 28 publications

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“…0.0001, n = 106). Although a similar but weak correlation between the barrier function and the disease severity of AD was reported in lesional skin [26][27][28] , that observation in this study of nonlesional skin strongly suggests that the decreased barrier function in nonlesional skin is an important factor that varies depending on the severity of AD. Thus, it is likely that the level of barrier function in the nonlesional skin is affected secondly by the intensity of cutaneous infl ammatory reaction seen in the lesional skin, suggesting its association with a postinfl ammatory response.…”

Section: Discussioncontrasting

confidence: 36%

Recharacterization of the Nonlesional Dry Skin in Atopic Dermatitis through Disrupted Barrier Function

Matsuki¹,

Kiyokane²,

Matsuki

et al. 2004

Exog Dermatol

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Background: The etiology of the nonlesional dry and barrier-disrupted skin of patients with atopic dermatitis (AD) is still unclear. Objective: To determine whether disrupted barrier function in the nonlesional skin is associated with inflammatory or postinflammatory events, which are relevant to the severity of AD or local dry skin properties, respectively. Methods: We evaluated the barrier function and the water content of nonlesional forearm skin and compared these with the severity of AD and the intensity of dryness/scaling/itchiness at the same skin sites. Results: The transepidermal water loss (TEWL) significantly increased in proportion to the severity of AD with a markedly high correlation coefficient (r = 0.834, p < 0.0001, n = 106), while the capacitance decreased in proportion to the severity of AD with a relatively lower correlation coefficient (r = –0.720, p < 0.0001, n = 106) compared with TEWL. Relationship between TEWL and capacitance values in association with the AD severity revealed that the two parameters are well distributed, corresponding to the severity of AD, and that the elevated TEWL more adequately reflects the difference between healthy control and the mild group of AD compared with the reduced capacitance. Comparison with dry skin properties revealed that while the capacitance values were highly correlated with dryness (r = –0.752, p < 0.0001, n = 106) and with scaling (r = –0.697, p < 0.0001, n = 106), the TEWL was also related to dryness (r = 0.788, p < 0.0001, n = 106) with a higher correlation coefficient compared with capacitance and to scaling (r = 0.697, p < 0.0001, n = 106). Conclusion: Our results indicate that the barrier disruption in the nonlesional skin is well suited to reflect the severity of AD as well as the dry skin properties, providing a useful insight into understandings of diagnosis and clinical improvement during therapy.

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Section: Discussioncontrasting

confidence: 36%

Recharacterization of the Nonlesional Dry Skin in Atopic Dermatitis through Disrupted Barrier Function

Matsuki¹,

Kiyokane²,

Matsuki

et al. 2004

Exog Dermatol

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“…Wykazuje dobrą korelację ze wskaźnikiem SCORAD oraz poziomem interleukiny 16 w surowicy w ostrym stadium choroby. Jest jedynym do tej pory narzędziem uwzględniającym funkcję bariery naskórka w ocenie nasilenia atopowego zapalenia skóry [42].…”

Section: Objective Severity Assessment Of Atopic Dermatitis (Osaad)unclassified

Assessment of the severity of atopic dermatitis

Bożek¹,

Reich²

2016

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“…OSAAD is a severity evaluation scale in AD including TEWL, SCH using a noninvasive bioengineering methods and estimation of affected body surface area (BSA). The method is suitable for both children and adults with AD compared with classical scoring system (Angelova-Fischer et al, 2005). The OSAAD score have several advantages over the clinical scoring methods.…”

Section: Assessment Of Clinical Scoring Systemsmentioning

confidence: 99%

“…The OSAAD score have several advantages over the clinical scoring methods. Measurement of TEWL and SCH is reproducible and reliable under given standard environment condition and instrument devices (Angelova-Fischer et al, 2005), able to evaluate quantitatively the severity scale of skin barrier impairment, sensitive to minor fluctuations in the course of AD development, and consequently applicable to assessment of treatment effects. The limitations of this technique are the inter-or intra-variability in AD patients, influenced by anatomic sites, environmental changes, etc.…”

Section: Assessment Of Clinical Scoring Systemsmentioning

confidence: 99%

Advances in Assessing the Severity of Atopic Dermatitis

Di¹,

Zhang²,

Lv³

et al. 2012

Atopic Dermatitis - Disease Etiology and Clinical Management

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The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis

Abstract: This is the first study validating the OSAAD score as a sensitive and reliable tool for the assessment of the severity of atopic dermatitis in adult patients.

Cited by 51 publications

References 28 publications

Recharacterization of the Nonlesional Dry Skin in Atopic Dermatitis through Disrupted Barrier Function

Recharacterization of the Nonlesional Dry Skin in Atopic Dermatitis through Disrupted Barrier Function

Assessment of the severity of atopic dermatitis

Advances in Assessing the Severity of Atopic Dermatitis

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