The obese inflammatory microenvironment may promote breast DCIS progression
Ola Habanjar,
Rawan Nehme,
Nicolas Goncalves-Mendes
et al.
Abstract:IntroductionDuctal carcinoma in situ (DCIS), characterized by a proliferation of neoplastic cells confined within the mammary ducts, is distinctly isolated from the surrounding stroma by an almost uninterrupted layer of myoepithelial cells (MECs) and by the basement membrane. Heightened interactions within the adipose microenvironment, particularly in obese patients, may play a key role in the transition from DCIS to invasive ductal carcinoma (IDC), which is attracting growing interest in scientific research. … Show more
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