The nutritional herb Epimedium grandiflorum inhibits the growth in a model for the Luminal A molecular subtype of breast cancer

Telang, Nitin T.; Gou, Li; Katdare, Meena; Sepkovic, Daniel W.; Bradlow, H. Leon; Wong, George Y.

doi:10.3892/ol.2017.5720

Cited by 20 publications

(16 citation statements)

References 29 publications

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“…Up to now, more than 270 compounds were isolated from Epimedium species. The major active components are flavonoids and corresponding derivatives, with antitumor, antioxidative, antiosteoporosis, and protective effects [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Study on DNA Barcoding of Medicinally Important Genus Epimedium L. (Berberidaceae)

Guo

Ren

et al. 2018

Genes

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Genus Epimedium consists of approximately 50 species in China, and more than half of them possess medicinal properties. The high similarity of species’ morphological characteristics complicates the identification accuracy, leading to potential risks in herbal efficacy and medical safety. In this study, we tested the applicability of four single loci, namely, rbcL, psbA-trnH, internal transcribed spacer (ITS), and ITS2, and their combinations as DNA barcodes to identify 37 Epimedium species on the basis of the analyses, including the success rates of PCR amplifications and sequencing, specific genetic divergence, distance-based method, and character-based method. Among them, character-based method showed the best applicability for identifying Epimedium species. As for the DNA barcodes, psbA-trnH showed the best performance among the four single loci with nine species being correctly differentiated. Moreover, psbA-trnH + ITS and psbA-trnH + ITS + rbcL exhibited the highest identification ability among all the multilocus combinations, and 17 species, of which 12 are medicinally used, could be efficiently discriminated. The DNA barcode data set developed in our study contributes valuable information to Chinese resources of Epimedium. It provides a new means for discrimination of the species within this medicinally important genus, thus guaranteeing correct and safe usage of Herba Epimedii.

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Section: Introductionmentioning

confidence: 99%

A Systematic Study on DNA Barcoding of Medicinally Important Genus Epimedium L. (Berberidaceae)

Guo

Ren

et al. 2018

Genes

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“…Non-toxic natural nutritional products may represent testable alternatives for endocrine therapy-resistant post-menopausal breast cancer (17,18,(28)(29)(30)(31), and thereby, may provide treatment options against the clinical limitations of current aromatase inhibitor-based therapy (2,3,6,9,10). Two species belonging to the Tabebuia genus have documented anti-cancer activity.…”

Section: Discussionmentioning

confidence: 99%

Growth inhibitory efficacy and anti‑aromatase activity of Tabebuia avellanedae in a model for post‑menopausal Luminal A breast cancer

Telang¹,

Nair

Wong³

2019

biom rep

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Aromatase inhibitors (AIs) represent a treatment option for post-menopausal estrogen receptor-positive (ER +) breast cancer as monotherapy, or in combination with cyclin-dependent kinase 4/6 or mTOR inhibitors. Long-term treatment with these agents leads to dose-limiting toxicity and drug resistance. Natural substances provide testable alternatives to current therapy. Tabebuia avellanedae (TA) tree is indigenous to the Amazon rainforest. The inner bark of TA represents a medicinal dietary supplement known as Taheebo. Non-fractionated aqueous extract from TA is an effective growth inhibitor in the Luminal A and triple negative breast cancer models. The quinone derivative naphthofurandione (NFD) is a major bioactive agent in TA. The present study examined the efficacy of finely ground powder from the inner bark of TA, available under the name of Taheebo-NFD-Marugoto (TNM). The ER + MCF-7 cells stably transfected with the aromatase gene MCF-7 AROM represented a model for aromatase-expressing post-menopausal breast cancer. Anchorage-independent colony formation, cell cycle progression, pro-apoptotic caspase 3/7 activity, apoptosis-specific gene expression, aromatase activity and select estradiol (E 2) target gene expression represented the mechanistic end points. Treatment of MCF-7 AROM cells with TNM induced a dose-dependent reduction in E 2-promoted anchorage-independent colony number. Mechanistic assays on TNM-treated MCF-7 AROM cells demonstrated that TNM at a concentration of 10 µg (NFD content: 2 ng), induced S-phase arrest, increased pro-apoptotic caspase 3/7 activity, increased pro-apoptotic BAX and decreased anti-apoptotic BCL-2 gene expression, and inhibited aromatase activity. Additionally, TNM treatment downregulated ESR-1 (gene for ER-α), aromatase and progesterone gene expression and reduced mRNA levels of E 2 target genes pS2, GRB2 and cyclin D1. Inhibition of aromatase activity, based on the NFD content of TNM was superior to the clinical AIs Letrozole and Exemestane. These data demonstrated the potential efficacy of TNM as a nutritional alternative for current therapy of aromatase positive, post-menopausal breast cancer.

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“…Breast cancer is a multifaceted and heterogeneous disease [ 95 ]. Based on the presence or absence of three molecular biomarkers, estrogen receptor-α (ER-α), progesterone receptor (PR), and human epidermal growth factor-2 (HER2), breast cancer is classified into five distinct molecular subtypes: (a) luminal A (positive for ER-α and/or PR while negative for HER-2); (b) luminal B (positive for ER-α and/or PR as well as HER2); (c) HER-2 overexpressing; (d) triple-negative; and (e) normal breast-like tumors [ 96 , 97 ]. Triple-negative breast cancer (TNBC) is a heterogenetic and aggressive subtype of breast cancer that is negative for the expression of ER-α, PR, and HER2 [ 98 ].…”

Section: Anticancer Activities Of Rutinmentioning

confidence: 99%

Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach

Nouri

Fakhri

Nouri

et al. 2020

Cancers

131

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Multiple dysregulated signaling pathways are implicated in the pathogenesis of cancer. The conventional therapies used in cancer prevention/treatment suffer from low efficacy, considerable toxicity, and high cost. Hence, the discovery and development of novel multi-targeted agents to attenuate the dysregulated signaling in cancer is of great importance. In recent decades, phytochemicals from dietary and medicinal plants have been successfully introduced as alternative anticancer agents due to their ability to modulate numerous oncogenic and oncosuppressive signaling pathways. Rutin (also known as rutoside, quercetin-3-O-rutinoside and sophorin) is an active plant-derived flavonoid that is widely distributed in various vegetables, fruits, and medicinal plants, including asparagus, buckwheat, apricots, apples, cherries, grapes, grapefruit, plums, oranges, and tea. Rutin has been shown to target various inflammatory, apoptotic, autophagic, and angiogenic signaling mediators, including nuclear factor-κB, tumor necrosis factor-α, interleukins, light chain 3/Beclin, B cell lymphoma 2 (Bcl-2), Bcl-2 associated X protein, caspases, and vascular endothelial growth factor. A comprehensive and critical analysis of the anticancer potential of rutin and associated molecular targets amongst various cancer types has not been performed previously. Accordingly, the purpose of this review is to present an up-to-date and critical evaluation of multiple cellular and molecular mechanisms through which the anticancer effects of rutin are known to be exerted. The current challenges and limitations as well as future directions of research are also discussed.

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The nutritional herb Epimedium grandiflorum inhibits the growth in a model for the Luminal A molecular subtype of breast cancer

Cited by 20 publications

References 29 publications

A Systematic Study on DNA Barcoding of Medicinally Important Genus Epimedium L. (Berberidaceae)

A Systematic Study on DNA Barcoding of Medicinally Important Genus Epimedium L. (Berberidaceae)

Growth inhibitory efficacy and anti‑aromatase activity of Tabebuia avellanedae in a model for post‑menopausal Luminal A breast cancer

Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach

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