The nutraceutical potential ofLepidium sativum L.seed flavonoid-rich extract in managing metabolic syndrome components

Abstract

The present study aimed to investigate the phytochemical and pharmacological identities of a Lepidium sativum L. (LS) flavonoid‐rich extract and its beneficial effects on metabolic, hormonal, and histological status. Chemical screening, as well as high‐performance liquid chromatography with diode‐array detection (HPLC‐DAD) identified high concentrations of the main flavonoid compounds in LS crude extract such as flavonols (quercetin, kaempferol), flavones (luteolin, apigenin), and especially flavanones (naringin, naringenin). Examinations of the biochemical and histopathological aspects showed the curative effects carried by LS flavonoid‐rich extracts on high‐fat diet‐fed Wistar rats. In this study, we propose that these molecules probably exerted the bioactivity observed in the treated group through improving insulin sensitivity, dyslipidemia, inflammation, and pancreas β cell integrity. Practical applications The LS seed is widely used in traditional medicine to treat hyperglycemia and inflammation. During the traditional mixture preparation, the thermal procedures could impair the bioactions of the most interesting group of LS phytoconstituants, flavonoids. In the present study, we propose an appropriate procedure to preserve those phytochemicals and suggest them as a substitute for the management of metabolic diseases. The dried LS extract showed an incredible set of effective flavonoids, which revealed hypoglycemic, hypolipidemic, anti‐inflammatory, cytoprotective, and antidiabetic activities. Thus, LS flavonoids constitute a remarkable product to consider in pharmaceutical industry targeting diabetes and heart diseases. Due to their enormous antioxidant potential, the LS flavonoids could be also used in food engineering and cosmetic preparations. Their practical applications is however often limited by low solubility and stability in lipophilic media. Therefore, a modification of the flavonoid structure is possibly required.

Anti-inflammatory and Immunomodulatory Properties of Lepidium sativum

“…Biochemical and histopathological examinations revealed the protective effects of L. sativum flavonoid-rich extracts on high-fat diet-fed Wistar rats. They suggested that flavonoids could improve insulin sensitivity, dyslipidemia, inflammation, and pancreatic β cell viability [ 62 ].…”

The efficacy of diet supplemented with Lepidium sativum (Chandrashoor) on expressed breast milk volume in hypogalactic mothers – An open-label noncross-over randomized trial

“…The increase in mammogenic hormonal levels has been proven in animal models secondary to action of bioactive flavonoids on mammary glands. [ 5 ] The animal models prove that the treatment of L. sativum seeds leads to growing of the dimension of lobules and an abundance of vesicles[ 6 7 ] with branching dilated alveoli for all animals in virgins, pregnant, and lactating rats. There are quite a few animal studies of L. sativum where it has been evaluated in animal models producing excellent results.…”

“…It has a high nutritional value as it is also rich in iron and proteins and used in the postnatal period for new mother as it gives her strength and stamina which eventually increases the breast milk production. [ 5 ] The galactogoggue effect of Lepidium sativus seeds has not been quantified in randomized control trials in humans till date. In this context, we propose to study the galactogogeus effect of L. sativum seeds in postnatal mothers through an open-label non crossover trial.…”

Health Benefits of Garden Cres Seeds

“…34 Rich amounts of flavonoids present in the L. sativum extract increase insulin sensitivity, inflammation, pancreatic cell integrity, and dyslipidemia. 35 Researches reveal that garden cress seeds contain trace elements that have antidiabetic properties. 36 Lepidine, semi-lepidine, and imidazole alkaloids found in L. sativum seeds also have an anti-diabetic effect by increasing the amount of insulin secreted by the surviving islet -cells in the pancreas.…”