We study the moduli space of congruence classes of isometric surfaces with the same mean curvature in 4-dimensional space forms. Having the same mean curvature means that there exists a parallel vector bundle isometry between the normal bundles that preserves the mean curvature vector fields. We prove that if both Gauss lifts of a compact surface to the twistor bundle are not vertically harmonic, then there exist at most three nontrivial congruence classes. We show that surfaces with a vertically harmonic Gauss lift possess a holomorphic quadratic differential, yielding thus a Hopf-type theorem. We prove that such surfaces allow locally a oneparameter family of isometric deformations with the same mean curvature. This family is trivial only if the surface is superconformal. For such compact surfaces with non-parallel mean curvature, we prove that the moduli space is the disjoint union of two sets, each one being either finite, or a circle. In particular, for surfaces in R 4 we prove that the moduli space is a finite set, under a condition on the Euler numbers of the tangent and normal bundles.We give an application to Lagrangian surfaces in R 4 . Let J be a canonical complex structure on R 4 which is compatible with the orientation, i.e., for orthonormal vectors e 1 , e 2 ∈ R 4 , the oriented orthonormal basis {e 1 , e 2 , Je 1 , Je 2