The Nudix Hydrolase 7 is an Acyl-CoA Diphosphatase Involved in Regulating Peroxisomal Coenzyme A Homeostasis

Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform

“…6A). Nudt7 expression in the liver decreases in the fasted state and increases in the fed state, showing an inverse correlated with the hepatic concentration of CoA (9,26). Conversely, Nudt19 mRNA and protein levels in the kidneys did not change between the fed and fasted states, in spite of the fact that this enzyme contributes to the regulation of kidney CoA levels.…”

“…Nudt7 mRNA and protein levels in the liver are regulated by the nutritional state and are inversely correlated with the tissue concentration of CoA (9,26).…”

Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism

“…More detailed 17 Human ACOT4 combines the activities of three separate peroxisomal murine esterase encoded by Acot3 , Acot4 , and Acot5 (174). investigations showed that NUDT7 acts also acyl-CoAs, both medium-and long-chain acyl-CoAs, even choloyl-CoA and pristanoyl-CoA ( 191,192 ). The physiological role of NUDT7 is unclear.…”

Identification of Novel Plant Peroxisomal Targeting Signals by a Combination of Machine Learning Methods and in Vivo Subcellular Targeting Analyses

“…NUDT19 is a member of the nudix hydrolase family. NUDT7 and RP2p are peroxisomal in mammals and act as diphosphatases that cleave esterified or free CoASH into acyl-or 49-phosphopantetheine and 39,59-ADP, thereby regulating peroxisomal CoA homeostasis (Gasmi and McLennan, 2001;Ofman et al, 2006;Reilly et al, 2008).…”