The nucleotide sequence of Saccharomyces cerevisiae chromosome VII

Tettelin, Hervé; Carbone, M.; Albermann, Kaj; Albers, M.; Arroyo, Javier; Backes, U.; Barreiros, Tania; Bertani, Iris; Bjourson, Anthony J.; Brückner, Margit; Bruschi, Carlo V.; Carignani, Giovanna; Castagnoli, Luisa; Cerdan, Esperanza; Clemente, Maria Luisa; Coblenz, A.; Coglievina, Maristella; Coissac, Éric; Defoor, E.; Bino, S. Del; Delius, Hajo; Delneri, Daniela; Wergifosse, P de; Dujon, Bernard; Durand, Patrick; Entian, K. D.; Eraso, P.; Escribano, V.; Fabiani, Lucia; Fartmann, Berthold; Feroli, Fiorella; Feuermann, Marc; Frontali, Laura; Garcı́a-González, Maria Asunción; García-Sáez, M. I.; Goffeau, André; Guerreiro, Paulo; Hani, Jean; Hansen, M.; Hebling, Ulrike; Hernandez, K.; Heumann, Klaus G.; Hilger, François; Hofmann, Birgit; Indge, K. J.; James, C. M.; Klima, Raffaella; Kötter, Peter; Krämer, Bernd; Kramer, Wilfried; Lauquin, Guy J.‐M.; Leuther, H.; Louis, Edward J.; Maillier, Evelyne; Marconi, Andrea; Martegani, Enzo; Mazón, M. J.; Mazzoni, Cristina; McReynolds, A. D. K.; Melchioretto, Pasquale; Mewes, Hans‐Werner; Minenkova, Olga; Müller-Auer, S.; Nawrocki, Arkadiusz; Netter, Pierre; Neu, R.; Nombela, C; Oliver, S. G.; Panzeri, Laura; Paoluzi, Serena; Plevani, Paolo; Portetelle, Daniel; Portillo, F.; Potier, Serge; Purnelle, Bénédicte; Rieger, Michael A.; Riles, Linda; Rinaldi, Teresa; Robben, Johan; Rodrigues-Pousada, Claudina; Rodrı́guez-Belmonte, Esther; Rodríguez-Torres, Ana María; Rose, Matthias; Ruzzi, Maurizio; Saliola, Mirella; Sánchez-Pérez, Miguel; Schäfer, B.; Schäfer, Melanie; Scharfe, M.; Schmidheini, Tobias; Schreer, A.; Skála, J; Souciet, Jean-Luc; Steensma, H. Yde; Talla, Emmanuel; Thierry, Agnès; Vandenbol, Micheline; Aart, Quirina J. M. Van Der; Dyck, L Van; Vanoni, Marco; Verhasselt, Peter; Voet, Maria-Helena; Volckaert, Guido; Wambutt, R.; Watson, Martin D.; Weber, Nico; Wedler, E.; Wedler, H.; Wipfli, P.; Wolf, K.; Wright, L. F.; Zaccaria, Paolo; Zimmermann, M.; Zollner, Alfred; Kleine, K.

doi:10.1038/387s081

Cited by 83 publications

(16 citation statements)

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“…We had completed sequencing the YCp14 insert when the sequence of yeast chromosome VII, obtained during systematic sequencing of the yeast genome, became available in the databases. The SpeI-SphI fragment of the insert is located in the left arm of the chromosome, from nucleotides 114971 to 119543 (Tettelin et al 1997). The sequences are identical for the two a Minimal medium was used with the nitrogen source as indicated.…”

Section: Resultsmentioning

confidence: 99%

Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily

et al. 1998

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The ARO8 and ARO9 genes of Saccharomyces cerevisiae were isolated by complementation of the phenylalanine/tyrosine auxotrophy of an aro8 and aro9 double-mutant strain that is defective in aromatic aminotransferase I (aro8) and II (aro9). The genes were sequenced, and deletion mutants were constructed and analysed. The expression of ARO8 and ARO9 was studied. The deduced amino acid sequences of Aro8p and Aro9p suggest that the former is a 500-residue, 56168-Da polypeptide and the latter a 513-residue, 58516-Da polypeptide. They correspond, respectively, to Ygl202p and Yhr137p, two putative proteins of unknown function revealed by systematic sequencing of the yeast genome. We show that aromatic aminotransferases I and II are homologous proteins, members of aminotransferase subgroup I, and, together with three other proteins, they constitute within the subgroup a new subfamily of enzymes specialised for aromatic amino acid and alpha-aminoadipate transamination. ARO8 expression is subject to the general control of amino acid biosynthesis. ARO9 expression is induced when aromatic amino acids are present in the growth medium and also in aro8 mutants grown on minimal ammonia medium. An autonomously replicating sequence (ARS) element is located between the ARO8 gene and YGL201c which encodes a protein of the minichromosome maintenance family.

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Section: Resultsmentioning

confidence: 99%

Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily

et al. 1998

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“…In this study, we show that S. cerevisiae NAMase is encoded by the YGL037C open reading frame (ORF) discovered during the systematic sequencing of the yeast genome (Tettelin et al ., 1997). Expression of the NAMase protein and transcript was found to increase when the cells were grown under a variety of stress conditions, this increase requiring the presence of four stress response elements (STREs) (Moskvina et al ., 1998) in the 5′ non‐coding region of YGL037C.…”

Section: Introductionmentioning

confidence: 99%

Identification and functional analysis of the Saccharomyces cerevisiae nicotinamidase gene, PNC1

Ghislain

Talla

François

2001

Yeast

115

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Nicotinamidase (NAMase) from the budding yeast, Saccharomyces cerevisiae, was purified by Ni(2+) affinity chromatography and gel filtration. N-terminal microsequencing revealed sequence identity with a hypothetical polypeptide encoded by the yeast YGL037C open reading frame sharing 30% sequence identity with Escherichia coli pyrazinamidase/nicotinamidase. A yeast strain in which the NAMase gene, hereafter named PNC1, was deleted shows a decreased intracellular NAD(+) concentration, consistent with the loss of NAMase activity in the null mutant. In wild-type strains, NAMase activity is stimulated during the stationary phase of growth, by various hyperosmotic shocks or by ethanol treatment. Using a P(PNC1)::lacZ gene fusion, we have shown that this stimulation of NAMase activity results from increased levels of the protein and requires stress response elements in the 5'non-coding region of PNC1. These results suggest that NAMase helps yeast cells to adapt to various stress conditions and nutrient depletion, most likely via the activation of NAD-dependent biological processes.

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“…Recently, the complete genome of Saccharomyces cerevisiae was analyzed by several groups (Oliver et al 1992;Dojon et al 1994Dojon et al , 1997Feldman et al 1994;Johnston et al 1994Johnston et al , 1997Bussey et al 1995Bussey et al , 1997Murakami et al 1995;Galibert et al 1996;Goffeau et al 1996;Bowman et al 1997;Churcher et al 1997;Dietrich et al 1997;Jacq et Philippsen et al 1997;Tettelin et al 1997). We used their data from GenomeNet (http://www.genome.ad.jp) and analyzed them with a personal computer.…”

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confidence: 99%

Gene assembly consisting of small units with similar amino acid composition in the Saccharomyces cerevisiae genome

Sorimachi

Okayasu

2003

Mycoscience

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Amino acid compositions of all genes in Saccharomyces cerevisiae were determined using a computer analysis of the complete genome. The amino acid composition of an assembly of several genes or a single gene consisted of 3000-7000 amino acid residues forming a certain pattern of amino acid composition. This rule was independent not only of the gene size, but also of the gene position. Thus, the small units, consisting of 3000-7000 amino acid residues, showed a similar amino acid composition, and they formed all the genes in the complete genome.

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The nucleotide sequence of Saccharomyces cerevisiae chromosome VII

Cited by 83 publications

References 0 publications

Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily

Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily

Identification and functional analysis of the Saccharomyces cerevisiae nicotinamidase gene, PNC1

Gene assembly consisting of small units with similar amino acid composition in the Saccharomyces cerevisiae genome

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