The Nucleoside Transporters CNTs and ENTs

Ho, Horace T. B.; Wang, Joanne

doi:10.1002/9781118705308.ch7

Cited by 6 publications

(3 citation statements)

References 119 publications

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“…Except PMAT, all other members of the SLC29 family, namely, ENT1‐3, function as nucleoside transporters that specifically transport purine and pyrimidine nucleosides (e.g., uridine, adenosine, cytidine) and their structural analogs ( Table ). ENT1 and 2 are classic nucleoside transporters that play important roles in cellular uptake of physiologic nucleosides and therapeutic nucleoside analogs (e.g., cytarabine, fludarabine) . ENT3 is an intracellular transporter crucial for lysosomal and mitochondrial nucleoside transport .…”

Section: Organic Cation Transport and The Discovery Of Pmatmentioning

confidence: 99%

“…ENT1 and 2 are classic nucleoside transporters that play important roles in cellular uptake of physiologic nucleosides and therapeutic nucleoside analogs (e.g., cytarabine, fludarabine). 5,6 ENT3 is an intracellular transporter crucial for lysosomal and mitochondrial nucleoside transport. 7,8 Alternatively named ENT4, PMAT was initially hypothesized to transport nucleosides or related compounds.…”

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confidence: 99%

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The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition

Wang

2016

Clin Pharma and Therapeutics

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Plasma membrane monoamine transporter (PMAT) is a new polyspecific organic cation transporter that transports a variety of biogenic amines and xenobiotic cations. Highly expressed in the brain, PMAT represents a major uptake2 transporter for monoamine neurotransmitters. At the blood–cerebrospinal fluid (CSF) barrier, PMAT is the principal organic cation transporter for removing neurotoxins and drugs from the CSF. Here I summarize our latest understanding of PMAT and its roles in monoamine uptake and xenobiotic disposition.

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Section: Organic Cation Transport and The Discovery Of Pmatmentioning

confidence: 99%

mentioning

confidence: 99%

The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition

Wang

2016

Clin Pharma and Therapeutics

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“…Likewise, the screening of a series of 7-substituted 7-deazainosine derivatives provided several 6-O-alkylated analogues (6)(7)(8)(9) with nanomolar in vitro potency and is thus interesting for further in vivo evaluation [21]. Another advantage of nucleoside analogues is their high likelihood to cross the blood-brain barrier due to the various purine transporters lining this barrier [22]. Sufficient compound exposure in the central nervous system is essential for efficacy against stage-II of the disease and is a requirement in the current target product profile [23].…”

Section: Introductionmentioning

confidence: 99%

4E Interacting Protein as a Potential Novel Drug Target for Nucleoside Analogues in Trypanosoma brucei

et al. 2021

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Human African trypanosomiasis is a neglected parasitic disease for which the current treatment options are quite limited. Trypanosomes are not able to synthesize purines de novo and thus solely depend on purine salvage from the host environment. This characteristic makes players of the purine salvage pathway putative drug targets. The activity of known nucleoside analogues such as tubercidin and cordycepin led to the development of a series of C7-substituted nucleoside analogues. Here, we use RNA interference (RNAi) libraries to gain insight into the mode-of-action of these novel nucleoside analogues. Whole-genome RNAi screening revealed the involvement of adenosine kinase and 4E interacting protein into the mode-of-action of certain antitrypanosomal nucleoside analogues. Using RNAi lines and gene-deficient parasites, 4E interacting protein was found to be essential for parasite growth and infectivity in the vertebrate host. The essential nature of this gene product and involvement in the activity of certain nucleoside analogues indicates that it represents a potential novel drug target.

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The synergy between nucleotide biosynthesis inhibitors and antiviral nucleosides: New opportunities against viral infections?

Miranda

2022

Archiv der Pharmazie

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5ʹ-Phosphorylated nucleoside derivatives are molecules that can be found in all living organisms and viruses. Over the last century, the development of structural analogs that could disrupt the transcription and translation of genetic information culminated in the development of clinically relevant anticancer and antiviral drugs.However, clinically effective broad-spectrum antiviral compounds or treatments are lacking. This viewpoint proposes that molecules that inhibit nucleotide biosynthesis may sensitize virus-infected cells toward direct-acting antiviral nucleosides. Such potentially synergistic combinations might allow the repurposing of drugs, leading to the development of new combination therapies.

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The Nucleoside Transporters CNTs and ENTs

Cited by 6 publications

References 119 publications

The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition

The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition

4E Interacting Protein as a Potential Novel Drug Target for Nucleoside Analogues in Trypanosoma brucei

The synergy between nucleotide biosynthesis inhibitors and antiviral nucleosides: New opportunities against viral infections?

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