The Nucleoprotein Complement-Fixation Test in the Diagnosis of Systemic Lupus Erythematosus

DNA haemagglutination test in the diagnosis of systemic lupus erythematosus.

“…The results are readily reproducible and highly specific. Rheumatoid arthritis has been found to be attended by antibodies to nucleoprotein, histone, and whole nucleus (Rothfield and others, 1961;Dorner, Enderlin, Spiegelberg, and Miescher, 1961;Thompson, 1962, Ward, Johnson, andHolborow, 1964); antibodies to nucleoprotein have been found in systemic scleroderma and dermatomyositis (Friou, 1958;Bardawil, Toy, Galins, and Bayles, 1958;Scalettar, Marcus, Simonton, and Muschel, 1960). Positive cell tests have been reported in all these diseases (Kievits, Goslings, Schuit, and Hijmans, 1956;Marmont, 1959;Rothfield and others, 1961).…”

My career as an immunoglycobiologist

“…1) In addition, I participated in a study that demonstrated that autoantibodies in the sera of patients with systemic lupus erythematosus bound to a nucleoprotein antigen. 2) …”

Εφαρμογη Της Ανοσοενζυματικης Μεθοδου Δια Την Αναζητησιν Αντιπυρηνικων Αντισωματων

“…Miescher et al 1953, Miescher and Fauconnet 1954. Ή άντίδρασις τοΰ LE παράγοντος μετά τοΰ ανω τέρω συμπλέγματος προκαλεί σύνδεσιν τοΰ συμπληρώματος, το όποιον είναι άπαραίτητον εις τον σχηματισμον τών LE κυττάρων, Scalettar et al 1960. Λοΰ πυρήνος, ύπο δε τών TAN καί KUNKEL (1966) αντίσωμα έναντι, άλλου τινός διαλυτού συστατικού τοϋ πυρήνος κληθέντος SM.…”