The nuclear-cytoplasmic ratio controls the cell cycle period in compartmentalized frog egg extract
Liliana Piñeros,
Nikita Frolov,
Daniel Ruiz-Reynés
et al.
Abstract:Each proliferating cell replicates its DNA and internal components before distributing this material evenly to its daughters. Although the regulation of cyclin-dependent kinases (Cdks) that dictate orderly cell cycle progression is well characterized, how the subcellular localization of the cell cycle machinery contributes to timing is not well understood. We investigated the influence of the nucleus by reconstituting cell cycle oscillations in droplets of frog egg extract in the absence or presence of a nucle… Show more
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