The NRAMP1 polymorphism as a risk factor for tuberculous spondylitis

Abstract

In the present study, we analysed the association between the incidence of tuberculous spondylitis with the Natural Resistance Associated Macrophage Protein 1 (NRAMP1, also known as Solute Carrier Family 11a member1) polymorphism by studying the genetic segregation of this polymorphism and the incidence of the disease among members of the West Javanese population undergoing surgery for tuberculous spondylitis at our institution. We compared the distribution of NRAMP1 polymorphism at two specific sites, namely D543N, and 3’UTR, among subjects with pulmonary tuberculosis and tuberculous spondylitis. We found no significant differences in distribution of polymorphism between the two groups, or between pulmonary tuberculosis and tuberculous spondylitis compared to healthy subjects. However, a pattern emerged in that polymorphisms at the two sites seemed to be protective against development of tuberculous spondylitis in our study population. We concluded that in the West Javanese population, there is no association between NRAMP1 polymorphism with the propensity for development of pulmonary tuberculosis or tuberculous spondylitis. In fact, NRAMP1 may provide protection against the development of tuberculous spondylitis.Key Wordstuberculous spondylitis, NRAMP1, polymorphism

Effect of Preoperative Anti Tuberculosis Drug Administration Duration on Tuberculous Spondylitis Surgical Treatment Outcomes

“…In endemic regions, such as Indonesia, the incidence of spinal tuberculosis is affected by several genetic factors that caused increased susceptibility to the disease, such as NRAMP1 gene polymorphism. 2 Studies involving West Javanese subjects had found increased susceptibility towards spinal tuberculosis due to Fok1 vitamin D receptor gene polymorphisms and vitamin D deficiency. 3 Patients with TB spondylitis and neurological deficits may have better outcome if surgery treatment was carried out in the early course of the disease.…”

Identification of HLA-DQA1 as a Susceptibility Gene for Spinal Tuberculosis by Exome Sequencing

“…Disease susceptibility is determined by a variety of factors, not just following the Mendelian genetic model. Multiple genes lead to STB genetic susceptibility, such as NRAMP1, the vitamin D receptor (VDR) [ 5 – 8 ]. Two methods are used to detect genetic susceptibility: candidate gene strategy and whole-genome scanning strategy.…”