The NPY intergeniculate leaflet projections to the suprachiasmatic nucleus transmit metabolic conditions

Saderi, Nadia; Cázarez-Márquez, Fernando; Buijs, Frederik N; Salgado‐Delgado, Roberto; Guzmán-Ruiz, Mara; Basualdo, M. del Carmen; Escobar, Carolina

doi:10.1016/j.neuroscience.2013.05.004

Cited by 58 publications

(47 citation statements)

References 53 publications

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“…However, RC-cut animals responded to metabolic cues not only with an altered neuronal activation of the ARC but also of the SCN, illustrating that for proper function both the ARC and SCN depend on their interconnectivity through the SCN-ARC axis. This is consistent with observations that altered metabolic conditions of an animal change the activity of the ARC and that of the SCN simultaneously (Yi et al, 2008; Saderi et al, 2013). Moreover, recent findings show that the SCN readily modulates glucose sensing in the ARC in a time dependent manner (Chao et al, 2016) and light not only directly changes the neuronal activity of the SCN but also that of the ARC (Guzmán-Ruiz et al, 2014) further confirming the significance of the SCN-ARC axis.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Suprachiasmatic Nucleus Interaction with the Arcuate Nucleus; Essential for Organizing Physiological Rhythms

Buijs

Guzmán-Ruiz

León-Mercado

et al. 2017

eNeuro

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The suprachiasmatic nucleus (SCN) is generally considered the master clock, independently driving all circadian rhythms. We recently demonstrated the SCN receives metabolic and cardiovascular feedback adeptly altering its neuronal activity. In the present study, we show that microcuts effectively removing SCN-arcuate nucleus (ARC) interconnectivity in Wistar rats result in a loss of rhythmicity in locomotor activity, corticosterone levels, and body temperature in constant dark (DD) conditions. Elimination of these reciprocal connections did not affect SCN clock gene rhythmicity but did cause the ARC to desynchronize. Moreover, unilateral SCN lesions with contralateral retrochiasmatic microcuts resulted in identical arrhythmicity, proving that for the expression of physiological rhythms this reciprocal SCN-ARC interaction is essential. The unaltered SCN c-Fos expression following glucose administration in disconnected animals as compared to a significant decrease in controls demonstrates the importance of the ARC as metabolic modulator of SCN neuronal activity. Together, these results indicate that the SCN is more than an autonomous clock, and forms an essential component of a larger network controlling homeostasis. The present novel findings illustrate how an imbalance between SCN and ARC communication through circadian disruption could be involved in the etiology of metabolic disorders.

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Section: Discussionsupporting

confidence: 92%

“…5). Also, merely fasting, known to result in a moderate decrease of c-Fos in the ventral SCN (Saderi et al, 2013) did not result in any change in the RC-cut animals. Furthermore, a comparison of SHAM and RC-cut animals showed a significantly elevated SCN c-Fos expression in RC-cut animals in all conditions as compared with SHAM animals.…”

Section: Resultsmentioning

confidence: 91%

Suprachiasmatic Nucleus Interaction with the Arcuate Nucleus; Essential for Organizing Physiological Rhythms

Buijs

Guzmán-Ruiz

León-Mercado

et al. 2017

eNeuro

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“…To quantify GAD, ENK, NPY, and CTb immunoreactivities, five sections representing IGL from each brain were analyzed bilaterally using ImageJ 1.48v software, which performed optical density (OD) measurements based on gray levels of pixels. OD has been used in previous reports to quantify similar immunostainings in IGL and SCN (Saderi et al 2013;Engelberth et al 2014). For these measurements, the background was subtracted from the positive staining.…”

Section: Image Analysis and Statisticsmentioning

confidence: 99%

“…Moreover, the main well-known function of IGL is to promote non-photic phase-shifting (e.g. such as behavioral arousal and food intake) due to NPY action in SCN, through geniculo-hypothalamic tract (GHT; Biello et al 1994;Janik et al 1995;Harrington 1997;Saderi et al 2013). Additionally, IGL is thought to have an integrative function of photic and non-photic stimuli, since it also mediates the effects of constant light exposure to circadian system (Harrington 1997;Morin and Pace 2002;Gall et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in neurochemical components and retinal projections of rat intergeniculate leaflet

Fiuza

Silva

Pessoa

et al. 2015

AGE

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Aging leads to several anatomical and functional deficits in circadian timing system. In previous works, we observed morphological alterations with age in hypothalamic suprachiasmatic nuclei, one central component of this system. However, there are few data regarding aging effects on other central components of this system, such as thalamic intergeniculate leaflet (IGL). In this context, we studied possible age-related alterations in neurochemical components and retinal projections of rat IGL. For this goal, young (3 months), adult (13 months), and aged (23 months) Wistar rats were submitted to an intraocular injection of neural tracer, cholera toxin subunit b (CTb), 5 days before a tissue fixation process by paraformaldehyde perfusion. Optical density measurements and cell count were performed at digital pictures of brain tissue slices processed by immunostaining for glutamic acid decarboxylase (GAD), enkephalin (ENK), neuropeptide Y (NPY) and CTb, characteristic markers of IGL and its retinal terminals. We found a significant age-related loss in NPY immunoreactive neurons, but not in immunoreactivity to GAD and ENK. We also found a decline of retinal projections to IGL with age. We conclude aging impairs both a photic environmental clue afferent to IGL and a neurochemical expression which has an important modulatory circadian function, providing strong anatomical correlates to functional deficits of the aged biological clock.

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“…The intergeniculate leaflet (IGL) is also involved in receiving inputs from the vestibulo-visuomotor system, implying that circadian rhythmicity might be influenced by head motion [17,18].…”

Section: Thalamusmentioning

confidence: 99%

Auditory/Visual Integration Assessment and Treatment in Brain Injury Rehabilitation

Zelinsky¹

2014

Traumatic Brain Injury

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The NPY intergeniculate leaflet projections to the suprachiasmatic nucleus transmit metabolic conditions

Cited by 58 publications

References 53 publications

Suprachiasmatic Nucleus Interaction with the Arcuate Nucleus; Essential for Organizing Physiological Rhythms

Suprachiasmatic Nucleus Interaction with the Arcuate Nucleus; Essential for Organizing Physiological Rhythms

Age-related changes in neurochemical components and retinal projections of rat intergeniculate leaflet

Auditory/Visual Integration Assessment and Treatment in Brain Injury Rehabilitation

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