“…Instead, damaged membrane proteins are targeted for endocytosis and pass through the multivesicular body (MVB) and to the lysosome (in yeast, the vacuole), where they are eventually degraded (Piper & Luzio, 2007; Zhao et al ., 2013). Bul1 plays an important role in this plasma membrane quality control system by facilitating the Rsp5 ‐ dependent polyubiquitination of multiple protein targets which directs their sorting to the vacuole for degradation (Yashiroda et al ., 1996; De Craene et al ., 2001; Helliwell et al ., 2001; Crespo et al ., 2004; Merhi & André, 2012; O'Donnell, 2012; Zhao et al ., 2013). Disruption of this membrane protein quality control pathway has been previously linked to accelerated aging (Fabrizio et al ., 2010), while the Rsp5/Bul1 node, in particular, has been shown to ameliorate the effects of protein aggregation in a model of neurodegenerative diseases (Tardiff et al ., 2013).…”