The novelty value of the combined use of electroencephalography and transcranial magnetic stimulation for neuroscience research

Komssi, Soile; Kähkönen, Seppo

doi:10.1016/j.brainresrev.2006.01.008

Cited by 169 publications

(151 citation statements)

References 67 publications

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“…EEG activity following single-pulse TMS (Figure 3) to the left motor cortex at an intensity required to produce a 1-mV peak-to-peak MEP amplitude (B120 percent of MT), and recorded from the CZ electrode produced recordings that were consistent with those published previously (eg, Figure 1a from Komssi et al; Komssi and Kahkonen, 2006).…”

Section: Resultssupporting

confidence: 83%

“…Arrows indicate peaks that are consistent with those published previously (eg, Figure 1a from Komssi et al; Komssi and Kahkonen, 2006). Figure 4 (a) Cortical evoked activity following single-and paired-pulse stimulation over the left motor cortex.…”

Section: Association Between Lici and Cortical Evoked Activity In Thesupporting

confidence: 82%

“…Such limitations have recently been overcome (Komssi et al, 2004). To date, several published studies have combined TMS with EEG to evaluate the neurophysiological effects of TMS directly on the cortex (Komssi and Kahkonen, 2006). For example, Komssi et al (Komssi and Kahkonen, 2006) demonstrated that TMS applied to the hand area of the motor cortex generates several evoked responses in global mean field amplitude waveforms, while the effect of the TMS stimulus artifact is negligible.…”

Section: Introductionmentioning

confidence: 99%

“…To date, several published studies have combined TMS with EEG to evaluate the neurophysiological effects of TMS directly on the cortex (Komssi and Kahkonen, 2006). For example, Komssi et al (Komssi and Kahkonen, 2006) demonstrated that TMS applied to the hand area of the motor cortex generates several evoked responses in global mean field amplitude waveforms, while the effect of the TMS stimulus artifact is negligible. Although these studies have been invaluable for assessing the effects of TMS on cortical excitability by single-pulse stimulation, assessment of CI by paired-pulse stimulation (eg, LICI) has yet to be demonstrated.…”

Section: Introductionmentioning

confidence: 99%

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Long-Interval Cortical Inhibition from the Dorsolateral Prefrontal Cortex: a TMS–EEG Study

Daskalakis

Farzan

Barr

et al. 2008

Neuropsychopharmacol

213

194

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Several studies have demonstrated that cortical inhibition (CI) can be recorded by paired transcranial magnetic stimulation (TMS) of the motor cortex and recorded by surface electromyography (EMG). However, recording CI from other cortical regions that are more closely associated with the pathophysiology of some neurological and psychiatric disorders (eg, dorsolateral prefrontal cortex (DLPFC) in schizophrenia) was previously unattainable. This study, therefore, was designed to investigate whether CI could be measured directly from the motor cortex and DLPFC by combining TMS with electroencephalography (EEG). Long-interval CI (LICI) is a TMS paradigm that was used to index CI in the motor cortex and DLPFC in healthy subjects. In the motor cortex, LICI resulted in significant suppression (32.8 ± 30.5%) of mean cortical evoked activity on EEG, which was strongly correlated with LICI recorded by EMG. In the DLPFC, LICI resulted in significant suppression (30.1±26.9%) of mean cortical evoked activity and also correlated with LICI in the motor cortex. These data suggest that CI can be recorded by combining TMS with EEG and may facilitate future research attempting to ascertain the role of CI in the pathophysiology of several neurological and psychiatric disorders.

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Section: Resultssupporting

confidence: 83%

Section: Association Between Lici and Cortical Evoked Activity In Thesupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long-Interval Cortical Inhibition from the Dorsolateral Prefrontal Cortex: a TMS–EEG Study

Daskalakis

Farzan

Barr

et al. 2008

Neuropsychopharmacol

213

194

View full text Add to dashboard Cite

show abstract

“…A further goal of this study was to investigate short and long-lasting tDCS effects by evaluating the time course of induced changes at~0 and 30 min after tDCS. We employed TMS-evoked cortical responses (i.e., TEPs) as a novel probe of tDCS-induced cortical excitability changes (Ilmoniemi et al, 1997;Komssi and Kahkonen, 2006;Miniussi and Thut, 2009;Miniussi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Excitability modulation of the motor system induced by transcranial direct current stimulation: A multimodal approach

2013

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Anodal and cathodal transcranial direct current stimulations (tDCS) are both established techniques to induce cortical excitability changes. Typically, in the human motor system, such cortical modulations are inferred through changes in the amplitude of the motor evoked potentials (MEPs). However, it is now possible to directly evaluate tDCS-induced changes at the cortical level by recording the transcranial magnetic stimulation evoked potentials (TEPs) using electroencephalography (EEG). The present study investigated the modulation induced by the tDCS on the motor system. The study evaluates changes in the MEPs, in the amplitude and distribution of the TEPs, in resting state oscillatory brain activity and in behavioral performance in a simple manual response task. Both the short-and long-term tDCS effects were investigated by evaluating their time course at~0 and 30 min after tDCS. Anodal tDCS over the left primary motor cortex (M1) induced an enhancement of corticospinal excitability, whereas cathodal stimulation produced a reduction. These changes in excitability were indexed by changes in MEP amplitude. More interestingly, tDCS modulated the cortical reactivity, which is the neuronal activity evoked by TMS, in a polarity-dependent and site-specific manner. Cortical reactivity increased after anodal stimulation over the left M1, whereas it decreased with cathodal stimulation. These effects were partially present also at long term evaluation. No polarity-specific effect was found either on behavioral measures or on oscillatory brain activity. The latter showed a general increase in the power density of low frequency oscillations (theta and alpha) at both stimulation polarities. Our results suggest that tDCS is able to modulate motor cortical reactivity in a polarity-specific manner, inducing a complex pattern of direct and indirect cortical activations or inhibitions of the motor system-related network, which might be related to changes in synaptic efficacy of the motor cortex.

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Disrupting dorsolateral prefrontal cortex by rTMS reduces the P300 based marker of deception

Karton

Bachmann

2017

Brain and Behavior

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ObjectiveQuite many studies have revealed certain brain‐process signatures indicative of subject's deceptive behavior. These signatures are neural correlates of deception. However, much less is known about whether these signatures can be modified by noninvasive brain stimulation techniques representing methods of causal intervention of brain processes and the corresponding behavior. Our purpose was to explore whether such methods have an effect on these signatures.MethodsIt is well known that electroencephalographic event‐related potential component, P300, is sensitive to perception of critical items in a concealed information test, one of the central methods in deception studies. We examined whether the relative level of expression of P300 as a neural marker of deception can be manipulated by means of noninvasive neuromodulation. We used EEG/ERP recording combined with (i) neuronavigated repetitive transcranial magnetic stimulation (rTMS) and (ii) concealed information detection test. An opportunistically recruited volunteer group of normal adults formed our experimental group.ResultsWe show that offline rTMS to dorsolateral prefrontal cortex attenuated relative P300 amplitude in response to the critical items compared to the neutral items.ConclusionNoninvasive prefrontal cortex excitability disruption by rTMS can be used to manipulate the sensitivity of ERP signatures of deception to critical items in a concealment‐based variant of lie detection test.

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The novelty value of the combined use of electroencephalography and transcranial magnetic stimulation for neuroscience research

Cited by 169 publications

References 67 publications

Long-Interval Cortical Inhibition from the Dorsolateral Prefrontal Cortex: a TMS–EEG Study

Long-Interval Cortical Inhibition from the Dorsolateral Prefrontal Cortex: a TMS–EEG Study

Excitability modulation of the motor system induced by transcranial direct current stimulation: A multimodal approach

Disrupting dorsolateral prefrontal cortex by rTMS reduces the P300 based marker of deception

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