The Novel Use of PVP K30 as Templating Agent in Production of Porous Lactose

Abstract

It is necessary to prepare porous lactose in order to improve the dissolution behavior of insoluble active ingredient. In this study, polyvinylpyrrolidone K30 (PVP K30) was firstly utilized as a templating agent with different use levels in preparing porous lactose. Then, the physical properties were profoundly characterized. Finally, the porous lactose was also employed as a health functional food/drug carrier to explore the effect on the dissolution behavior of curcumin. The results confirmed that (i) porous lactose was successfully prepared using PVP K30 as templating agent; (ii) PVP K30 significantly improved the yield of lactose in the spray drying; (iii) the improved powder properties of porous lactose were more conducive to the downstream operating process for the preparation of health functional food or drug; and (iv) the porous lactose significantly improved the dissolution behavior of curcumin. Therefore, the results obtained are beneficial to boosting the development of porous materials.

Surface Modifiers on Composite Particles for Direct Compaction

“…First, they were separately prepared by co-spray drying. Then, the PVP was removed to prepare porous lactose [ 113 ]. When compared to the unprocessed lactose, the co-processed products exhibited improved flowability: (i) the AR was decreased from 56.7° to 42.2°, 40.5°, 40.0°, respectively; (ii) the Carr’s index was decreased from 47.0 to 31.7, 28.7, 32.3, respectively; and (iii) the Hausner ratio was decreased from 1.89 to 1.46, 1.40, 1.48, respectively.…”

Evaluation of Hydrophilic and Hydrophobic Silica Particles on the Release Kinetics of Essential Oil Pickering Emulsions

“…The specific surface area was calculated by the Brunauer–Emmett–Teller (BET) and Langmuir models, and the pore volume and pore size distribution were obtained by the Barrett–Joyner–Halenda (BJH) model based on adsorption data. Prior to measurement, the samples were degassed at 80 °C for 5 h in a FlowPrep 060 Sample Degas System (Micromeritics) …”

“…Particle size distribution was determined using laser diffraction of a Mastersizer 2000 (Malvern, U.K.) with a Hydro 2000MU dispersion unit by dispersing the powder in water for hydrophilic samples or ethanol for hydrophobic samples …”

“…Prior to measurement, the samples were degassed at 80 °C for 5 h in a FlowPrep 060 Sample Degas System (Micromeritics). 57 The morphology of silica samples was determined using a Quanta 250 scanning electron microscope (SEM). Before the measurement, each sample was sputter-coated with gold to increase electrical conductivity.…”

“…56 Particle size distribution was determined using laser diffraction of a Mastersizer 2000 (Malvern, U.K.) with a Hydro 2000MU dispersion unit by dispersing the powder in water for hydrophilic samples or ethanol for hydrophobic samples. 57 The bulk density (ρ) of the powder was measured by pouring the sample into a cylinder with a volume of 100 mL, scraping off the excess powder on the surface, weighing the mass, and calculating the bulk density as the ratio of mass occupied to the volume. 58 When the particle was a sphere, the ratio of the inner area (RI) of the silica samples was calculated as the ratio between the specific surface area and the geometric area.…”