The novel treatments based on tissue engineering, cell therapy and nanotechnology for cutaneous leishmaniasis

Abpeikar, Zahra; Safaei, Mohsen; Alizadeh, Ali; Goodarzi, Arash; Hatam, Gholamreza

doi:10.1016/j.ijpharm.2023.122615

Cited by 10 publications

(8 citation statements)

References 196 publications

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“…Liposomes and polymeric nanoparticles can transport drugs directly to infected cells, thereby improving therapeutic efficacy [ 72 ]. Studies have confirmed that the utilization of nanoparticles for drug delivery induces leishmanicidal mechanisms, such as the increased generation of free radicals, the disruption of the mitochondrial membrane, and the suppression of the enzyme trypanothionine reductase [ 73 ].…”

Section: Resultsmentioning

confidence: 99%

Overview of Research on Leishmaniasis in Africa: Current Status, Diagnosis, Therapeutics, and Recent Advances Using By-Products of the Sargassaceae Family

Abdoul-Latif,

Oumaskour,

Abdallah

et al. 2024

Pharmaceuticals

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Leishmaniasis in Africa, which has been designated as a priority neglected tropical disease by various global organizations, exerts its impact on millions of individuals, primarily concentrated within this particular region of the world. As a result of the progressively grave epidemiological data, numerous governmental sectors and civil organizations have concentrated their endeavors on this widespread outbreak with the objective of devising appropriate remedies. This comprehensive examination delves into multiple facets of this parasitic ailment, scrutinizing the associated perils, diagnostic intricacies, and deficiencies within the existing therapeutic protocols. Despite the established efficacy of current treatments, they are not immune to deleterious incidents, particularly concerning toxicity and the emergence of parasitic resistance, thus accentuating the necessity of exploring alternative avenues. Consequently, this research not only encompasses conventional therapeutic approaches, but also extends its scope to encompass complementary and alternative medicinal techniques, thereby striving to identify innovative solutions. A particularly auspicious dimension of this study lies in the exploration of natural substances and by-products derived from some brown algae of the Sargassaceae family. These resources possess the potential to assume a pivotal role in the management of leishmaniasis.

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Section: Resultsmentioning

confidence: 99%

Overview of Research on Leishmaniasis in Africa: Current Status, Diagnosis, Therapeutics, and Recent Advances Using By-Products of the Sargassaceae Family

Abdoul-Latif,

Oumaskour,

Abdallah

et al. 2024

Pharmaceuticals

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“…One of the main issues in the pharmaceutical and cosmetic industries is cutaneous infections [ 21 ]. By 2021, it is anticipated that the global market for skin disease treatment technologies would have grown to $20.4 billion from its estimated $17.1 billion in 2015, and revenue is expected to show an annual growth rate (CAGR 2023–2028) of 5.62%, resulting in a market volume of US$21.65bn by 2028.…”

Section: Past Research and Discussionmentioning

confidence: 99%

Nanoparticles assisted intra and transdermic delivery of antifungal ointment: an updated review

Tarannum,

Pooja,

Jakhar

et al. 2024

Discover Nano

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This review paper highlights the trans-dermic delivery of nanoparticles (NPs) based antifungal ointments with the help of nanotechnology. It also describes the novel trans-dermal approach utilizing various nanoparticles which enables an efficient delivery to the target site. This current review gives an overview about past research and developments as well as the current nanoparticle-based ointments. This review also presents data regarding types, causes of infection, and different pathogens within their infection site. It also gives information about antifungal ointments with their activity and side effects of antifungal medicines. Additionally, this review also focuses on the future aspects of the topical administration of nanoparticle-based antifungal ointments. These nanoparticles can encapsulate multiple antifungal drugs as a combination therapy targeting different aspects of fungal infection. Nanoparticles can be designed in such a way that they can specifically target fungal cells and do not affect healthy cells. Nanoparticle based antifungal ointments exhibit outstanding potential to treat fungal diseases. As further research and advancements evolve in nanotechnology, we expect more development of nanoparticle-based antifungal formulations shortly. This paper discusses all the past and future applications, recent trends, and developments in the various field and also shows its bright prospective in the upcoming years. Graphical abstract

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“…The intracellular amastigote form of Leishmania spp . allocates in macrophage phagolysosomes from infected individuals [ 63 ]. However, the intracellular uptake of bioactive molecules is especially hindered for hydrophobic molecules [ 64 ], making it difficult for the drug to reach the parasite.…”

Section: Reviewmentioning

confidence: 99%

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

Dourado,

Silva Medeiros,

do Nascimento Alencar

et al. 2024

Beilstein J. Nanotechnol.

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Leishmaniasis is a neglected tropical disease that has affected more than 350 million people worldwide and can manifest itself in three different forms: cutaneous, mucocutaneous, or visceral. Furthermore, the current treatment options have drawbacks which compromise efficacy and patient compliance. To face this global health concern, new alternatives for the treatment of leishmaniasis have been explored. Curcumin, a polyphenol obtained from the rhizome of turmeric, exhibits leishmanicidal activity against different species of Leishmania spp. Although its mechanism of action has not yet been fully elucidated, its leishmanicidal potential may be associated with its antioxidant and anti-inflammatory properties. However, it has limitations that compromise its clinical use. Conversely, nanotechnology has been used as a tool for solving biopharmaceutical challenges associated with drugs, such as curcumin. From a drug delivery standpoint, nanocarriers (1–1000 nm) can improve stability, increase solubility, promote intracellular delivery, and increase biological activity. Thus, this review offers a deep look into curcumin-loaded nanocarriers intended for the treatment of leishmaniasis.

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The novel treatments based on tissue engineering, cell therapy and nanotechnology for cutaneous leishmaniasis

Cited by 10 publications

References 196 publications

Overview of Research on Leishmaniasis in Africa: Current Status, Diagnosis, Therapeutics, and Recent Advances Using By-Products of the Sargassaceae Family

Overview of Research on Leishmaniasis in Africa: Current Status, Diagnosis, Therapeutics, and Recent Advances Using By-Products of the Sargassaceae Family

Nanoparticles assisted intra and transdermic delivery of antifungal ointment: an updated review

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

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