The novel RUNX3/p33 isoform is induced upon monocyte-derived dendritic cell maturation and downregulates IL-8 expression

Puig‐Kröger, Amaya; Aguilera-Montilla, Noemí; Martínez-Nuñez, Rocío T.; Domínguez-Soto, Ángeles; Sánchez-Cabo, Fátima; Martín‐Gayo, Enrique; Zaballos, Ángel; Toribio, Marı́a L.; Groner, Yoram; Ito, Yoshiaki; Dopazo, Ana; Corcuera, María Teresa; Martín, María Julia; Vega, Miguel A.; Corbí, Ángel L.

doi:10.1016/j.imbio.2010.05.018

Cited by 19 publications

(21 citation statements)

References 51 publications

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“…A growing body of literature suggests that RUNX3 plays an important role in normal immune system development [56,57], susceptibility to early life disease as a result of in utero exposures [41], and many cancers [58-68]. RUNX3 is important for normal cellular differentiation and development, including T-cell differentiation [56,57,66,69], macrophage differentiation [70], neuronal cell development [71] and cell-cycle progression [63], and is known to negatively regulate dendritic cell maturation [72]. RUNX3 is a tumor suppressor gene [58,60,62,67,73,74] and it interacts with β-catenin [61].…”

Section: Discussionmentioning

confidence: 99%

Placental DNA Methylation Alterations Associated with Maternal Tobacco Smoking at the RUNX3 Gene are also Associated with Gestational Age

et al. 2013

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Aims The developmental origins of health and disease hypothesis states that later-life disease may be influenced by the quality of the in utero environment. Environmental toxicants can have detrimental effects on fetal development, potentially through effects on placental development and function. Maternal smoking during pregnancy is associated with low birth weight, preterm birth and other complications, and exposure to cigarette smoke in utero has been linked to gross pathologic and molecular changes to the placenta, including differential DNA methylation in placental tissue. The aim of this study was to investigate the relationship between maternal smoking during pregnancy, methylation changes in the placenta and gestational age. Materials & methods We used Illumina®’s (CA, USA) Human Methylation27 BeadChip technology platform to investigate the methylation status of 21,551 autosomal, non-SNP-associated CpG loci in DNA extracted from 206 human placentas and examined loci whose variation in methylation was associated with maternal smoking during pregnancy. Results We found that methylation patterns of a number of loci within the RUNX3 gene were significantly associated with smoking during pregnancy, and one of these loci was associated with decreased gestational age (p = 0.04). Conclusion Our findings, demonstrating maternal smoking-induced changes in DNA methylation at specific loci, suggest a mechanism by which in utero tobacco smoke exposure could exert its detrimental effects upon the health of the fetus.

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Section: Discussionmentioning

confidence: 99%

Placental DNA Methylation Alterations Associated with Maternal Tobacco Smoking at the RUNX3 Gene are also Associated with Gestational Age

et al. 2013

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“…6) are consistent with recent findings showing that CD36 expression is increased by p33 but suppressed by p44, and CD11a or CD11c promoter activity is suppressed by p33 but increased by p44. 33 Although it has been suggested that p33 could compete with p44 for binding to cofactors such as TLE1, 33 the detailed mechanism mediating these opposing effects needs to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Increased genetic susceptibility to intestinal‐type gastric cancer is associated with increased activity of the RUNX3 distal promoter

Lim

Kim

et al. 2011

Cancer

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“…In addition to DC differentiation and maturation, RUNX3 regulates CD11c and chemokine expression in an isoform‐specific manner in vitro . As DC are central coordinators of adaptive immune responses and self‐tolerance, the importance of Runx proteins in their differentiation will have far‐reaching effects in the immune system.…”

Section: Runx In Myeloid Cell Specification and Functionsmentioning

confidence: 98%

“…105 In addition to DC differentiation and maturation, RUNX3 regulates CD11c and chemokine expression in an isoform-specific manner in vitro. 106 As DC are central coordinators of adaptive immune responses and self-tolerance, the importance of Runx proteins in their differentiation will have far-reaching effects in the immune system. In addition to DC, a recent study showed that specific ablation of the Runx1c isoform in mice resulted in a drastic reduction in granulocytic basophils, owing to a block in the transition of granulocyte progenitors to basophil progenitors.…”

Section: Runx In Myeloid Cell Specification and Functionsmentioning

confidence: 99%

The RUNX complex: reaching beyond haematopoiesis into immunity

2015

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SummaryAmong their diverse roles as transcriptional regulators during development and cell fate specification, the RUNX transcription factors are best known for the parts they play in haematopoiesis. RUNX proteins are expressed throughout all haematopoietic lineages, being necessary for the emergence of the first haematopoietic stem cells to their terminal differentiation. Although much progress has been made since their discoveries almost two decades ago, current appreciation of RUNX in haematopoiesis is largely grounded in their lineage-specifying roles. In contrast, the importance of RUNX to immunity has been mostly obscured for historic, technical and conceptual reasons. However, this paradigm is likely to shift over time, as a primary purpose of haematopoiesis is to resource the immune system. Furthermore, recent evidence suggests a role for RUNX in the innate immunity of non-haematopoietic cells. This review takes a haematopoiesis-centric approach to collate what is known of RUNX's contribution to the overall mammalian immune system and discuss their growing prominence in areas such as autoimmunity, inflammatory diseases and mucosal immunity.

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The novel RUNX3/p33 isoform is induced upon monocyte-derived dendritic cell maturation and downregulates IL-8 expression

Cited by 19 publications

References 51 publications

Placental DNA Methylation Alterations Associated with Maternal Tobacco Smoking at the RUNX3 Gene are also Associated with Gestational Age

Placental DNA Methylation Alterations Associated with Maternal Tobacco Smoking at the RUNX3 Gene are also Associated with Gestational Age

Increased genetic susceptibility to intestinal‐type gastric cancer is associated with increased activity of the RUNX3 distal promoter

The RUNX complex: reaching beyond haematopoiesis into immunity

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