The Novel Role of the NLRP3 Inflammasome in Mycotoxin-Induced Toxicological Mechanisms
Chengshui Liao,
Fengru Xu,
Zuhua Yu
et al.
Abstract:Mycotoxins are secondary metabolites produced by several fungi and moulds that exert toxicological effects on animals including immunotoxicity, genotoxicity, hepatotoxicity, teratogenicity, and neurotoxicity. However, the toxicological mechanisms of mycotoxins are complex and unclear. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is a multimeric cytosolic protein complex composed of the NLRP3 sensor, ASC adapter protein, and caspas… Show more
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