The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells

Campadelli-Fiume, Gabriella; Cocchi, Francesca; Menotti, Laura; Lopez, Marc

doi:10.1002/1099-1654(200009/10)10:5<305::aid-rmv286>3.0.co;2-t

Cited by 230 publications

(158 citation statements)

References 75 publications

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“…As shown in Figure 1, three cell lines (HEL, Ronald and CCD-1140Sk) were refractory to BHV-1-mediated CPE induction, whereas three different cell lines (Ventressca, MRC-5 and BJ) showed CPE after high multiplicity infection with BHV-1. Although it is possible that HEL, Ronald and CCD1140Sk fail to show CPE after BHV-1 infection due to the inability of BHV-1 to enter into these cell lines, this possibility is unlikely given that BHV-1 recognizes the same attachment and entry receptors on human cells as HSV-1, 18 and all of the cell lines used in this study are susceptible and permissive to infection by wild-type HSV-1 (data not shown).…”

Section: Bhv-1 Replication Is Restricted In Normal Human Cellsmentioning

confidence: 91%

“…The structure and life cycle of BHV-1 are similar to HSV-1, including the recognition of the attachment and entry receptors heparin sulfate and nectin-1. 18 However, unlike HSV-1, BHV-1 is unable to bind to host nectin-2, but is capable of recognizing the poliovirus receptor CD155, 18 a receptor associated with tumor cell migration and invasion. 19 One of the interesting features of BHV-1 is its strict host range compared with other herpesviruses, including HSV-1.…”

Section: Introductionmentioning

confidence: 99%

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Bovine herpesvirus type 1 as a novel oncolytic virus

2009

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Oncolytic virotherapy is a promising avenue of cancer gene therapy. Current vectors include human viruses that have been engineered to replicate in tumor cells or nonhuman viruses that are naturally oncotropic and preferentially replicate in tumor cells harboring defects in innate immune pathways such as the type 1 interferon (IFN) pathway. Bovine herpesvirus type 1 (BHV-1) is a species-specific herpesvirus closely related to the human herpes simplex virus type 1 (HSV-1). Although BHV-1 does not efficiently replicate in and affect cellular viability of normal human cells, it is capable of infecting and killing various immortalized and transformed human cell types. Surprisingly, BHV-1 infection of human cells fails to elicit IFN production at the mRNA or protein level and the ability of BHV-1 to kill immortalized and transformed human cells does not correlate with defects in IFN pathways. Furthermore, although some cross-reactivity between BHV-1 and HSV-1 exists, the majority of human antibody or serum samples tested failed to neutralize BHV-1 despite possessing HSV-1 neutralizing capacity. Thus, BHV-1 is a novel candidate oncolytic virus with a distinct mechanism of tumor targeting.

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Section: Bhv-1 Replication Is Restricted In Normal Human Cellsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Bovine herpesvirus type 1 as a novel oncolytic virus

2009

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“…It is clear that GAGs play a role in infection by herpes simplex virus (HSV) and human immunodeficiency virus (HIV) based on the inhibitory effect of heparin and synthetic polyanions on viral infection. 52,53 Heparin-binding motifs in animal proteins, such as growth factors, 54 are also found in viral envelope proteins, suggesting that virus infection might be linked to viral binding to sites on HSPGs involved in growth factor signaling. Furthermore, a study of the specific sequences in HS that bound growth factors and the tissue/organ distribution of HS with these sequences have helped explain the tropism of viral diseases including Dengue 55 virus and hepatitis C virus (HPCV).…”

Section: Pathogen Recognitionmentioning

confidence: 99%

“…Recent studies on HSV suggest that a specific isoform of 3-O-sulfotransferase is capable of introducing a sulfo group critical for both binding and entry of HSV into its host cell 53,58 ( Figure 5). Furthermore, the distribution of this isoform offers an explanation of the susceptibility of brain to HSV infection.…”

Section: Pathogen Recognitionmentioning

confidence: 99%

Role of Glycosaminoglycans in Cellular Communication

2004

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Glycosaminoglycans are of critical importance in intercellular communication in organisms. This ubiquitous class of linear polyanions interacts with a wide variety of proteins, including growth factors and chemokines, which regulate important physiological processes. The presence of glycosaminoglycans on cell membranes and in the extracellular matrix also has resulted in their exploitation by infectious pathogens to gain access and entry into animal cells. This Account examines the structural and physical characteristics of these molecules responsible for their interaction with proteins important in cell-cell communication.

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“…Moreover, CD155 is member of the nectin family; 78 its paralogs have wide tissue distribution, 71 including hematopoietic tissues, and include Herpesviridae receptors. 83 There are multiple clinical scenarios where PV-derived vectors could be employed into clinical therapeutic strategies and fill a gap, which is currently not covered by conventional HSC vector systems. All conventional vector systems are replication incompetent.…”

Section: Poliovirus In Hematopoietic Stem Cells M Freistadt Et Almentioning

confidence: 99%

CD34+ hematopoietic stem cells support entry and replication of poliovirus: a potential new gene introduction route

et al. 2013

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Pluripotent hematopoietic stem cells (HSC) are critical in sustaining and constantly renewing the blood and immune system. The ability to alter biological characteristics of HSC by introducing and expressing genes would have enormous therapeutic possibilities. Previous unpublished work suggested that human HSC co-express CD34 (cluster of differentiation 34; an HSC marker) and CD155 (poliovirus receptor; also called Necl-5/Tage4/PVR/CD155). In the present study, we demonstrate the co-expression of CD34 and CD155 in primary human HSC. In addition, we demonstrate that poliovirus infects and replicates in human hematopoietic progenitor cell lines. Finally, we show that poliovirus replicates in CD34 þ enriched primary HSC. CD34 þ enriched HSC co-express CD155 and support poliovirus replication. These data may help further understanding of poliovirus spread in vivo and also demonstrate that human HSC may be amenable for gene therapy via poliovirus-capsid-based vectors. They may also help elucidate the normal function of Necl-5/Tage4/PVR/CD155.

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The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells

Cited by 230 publications

References 75 publications

Bovine herpesvirus type 1 as a novel oncolytic virus

Bovine herpesvirus type 1 as a novel oncolytic virus

Role of Glycosaminoglycans in Cellular Communication

CD34+ hematopoietic stem cells support entry and replication of poliovirus: a potential new gene introduction route

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