2013
DOI: 10.1016/j.jbior.2012.10.004
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The novel poly(A) polymerase Star-PAP is a signal-regulated switch at the 3′-end of mRNAs

Abstract: The mRNA 3′-untranslated region (3′-UTR) modulates message stability, transport, intracellular location and translation. We have discovered a novel nuclear poly(A) polymerase termed Star-PAP (nuclear speckle targeted PIPKIα regulated-poly(A) polymerase) that couples with the transcriptional machinery and is regulated by the phosphoinositide lipid messenger phosphatidylinositol-4,5-bisphosphate (PI4,5P2), the central lipid in phosphoinositide signaling. PI4,5P2 is generated primarily by type I phosphatidylinosi… Show more

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Cited by 27 publications
(27 citation statements)
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“…Moreover, in the nucleus, PtdIns(4,5) P 2 regulates the activity of a poly(A) polymerase, termed Star-PAP (nuclear speckle targeted PIPKIalpha regulated-poly(A) polymerase) to selectively control the expression of some targeted genes [101]. In humans, PtdIns(4,5) P 2 plays also a major role in regulating various signaling pathways, namely because of the rapid switching it can undergo thanks to the different PPIn kinases and phosphatases using it as a substrate (Figure 1).…”
Section: Ptdins(45)p2 a Phosphoinositide Involved In Actin Dynammentioning
confidence: 99%
“…Moreover, in the nucleus, PtdIns(4,5) P 2 regulates the activity of a poly(A) polymerase, termed Star-PAP (nuclear speckle targeted PIPKIalpha regulated-poly(A) polymerase) to selectively control the expression of some targeted genes [101]. In humans, PtdIns(4,5) P 2 plays also a major role in regulating various signaling pathways, namely because of the rapid switching it can undergo thanks to the different PPIn kinases and phosphatases using it as a substrate (Figure 1).…”
Section: Ptdins(45)p2 a Phosphoinositide Involved In Actin Dynammentioning
confidence: 99%
“…PIPKIα specifically associates with the PI4,5P 2 effector Star-PAP (for S peckle T argeted P IPKIα R egulated- P oly( A ) P olymerase, a non-canonical poly(A) polymerase (PAP), that is critical for the 3’ cleavage, polyadenylation and expression of select mRNAs [183, 195]. Sufficient evidence indicates that PIPKIα, PI4,5P 2 and Star-PAP function together in a complex to control the mRNA processing and expression of select mRNAs [182, 183, 196].…”
Section: Pip Kinases Regulate Pi45p2 Effectors In the Nucleusmentioning
confidence: 99%
“…This again highlights the paradigm where PIPKIs define the specificity of PI4,5P 2 signaling by associating with PI4,5P 2 effectors, in this case PKCδ. The collaborative roles for PIPKIα, PI4,5P 2 , and PKCδ in Star-PAP control of DNA damage induced expression of the apoptotic gene BIK [182, 195] (Figure 4). …”
Section: Pip Kinases Regulate Pi45p2 Effectors In the Nucleusmentioning
confidence: 99%
See 1 more Smart Citation
“…Moreover, the reported presence of PI(4)P5Ks, one of the two key enzymes in PtdIns(4,5) P 2 production, in the nucleus seems to underscore the pivotal importance of PtdIns(4,5) P 2 in nuclear functions. Interestingly, the PI(4)P5KIα and its product PtdIns(4,5) P 2 are suggested to take part in transcription control of certain types of genes through their interaction with poly(A) polymerase termed ‘Star-PAP’ in the nucleus 21 , 43 . Recent studies also indicate the presence of PI(5)P and its metabolizing enzyme PI(5)P4Ks in the nucleus, 12 , 14 , 16 , 44 , 45 thereby demonstrating the widespread expression of a variety of PI kinases in the nucleus.…”
Section: Discussionmentioning
confidence: 99%