The novel phytocomponent asiaticoside-D isolated from Centella asiatica exhibits monoamine oxidase-B inhibiting potential in the rotenone degenerated cerebral ganglions of Lumbricus terrestris

Counter effects of Asiaticosids-D through putative neurotransmission on rotenone induced cerebral ganglionic injury in Lumbricus terrestris

“…C. asiatica has been reported to biological activities desired for human health such as wound healing (Somboonwong et al, 2012), anti-inflammatory (George et al, 2009) and antioxidant activities (Hamid et al, 2002). In agreement with such reports and also with our previous reports on Asiaticoside-D (Gohil et al, 2010; Subaraja and Vanisree, 2019c), the current study was designed to an ROT induced ganglionic degeneration in worms and suggests that the Asiaticoside-D deserves against future studies for its use as an effective medicine that could minimize the morbidity of ganglionic degenerative disease patient.…”

“…Increase in the serotonergic neurotransmission can cause an increased locomotor activity while decrease in serotonergic neurotransmission can result in the decreased locomotor activity (Gardner, 1976). Thus, the previously reported by Subaraja and Vanisree, (2019c) the dysfunctional locomotion, swimming, crawling and cognitive functions in worms could be correlated to the DAT, OAT, TBH changes in ROT induced worms, Asiaticoside-D could maintain the neurotransmitter pathways of CGs, perhaps by regulating octopamine levels that could modulate the motor co-ordination. OAT is the major transporters by which octopamine are up taken from extracellular fluid; however, when OAT function or expressions are altered and the levels of other monoamine transporters are alerted (Gallant et al, 2003).…”

“…The laboratory maintained Lumbricus terrestris was maintained and groupings were randomly divided into five groups with each group containing twelve worms as previously described by Subaraja and Vanisree, (2019c).…”

Centella asiatica Protects d-Galactose/AlCl3 Mediated Alzheimer’s Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus

“…Centella asiatica (CA), locally known as “pegaga” in Malaysia is one of the valuable herbal medicine widely used in the treatment of various chronic ailments and also is proved to be safe and effective [15,16]. It is used in Ayurveda and Chinese traditional medicine to reverse/treat cognitive impairment and to enhance cognitive functions.…”

Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease

“…Madecassoside was also found to be effective at ameliorating the deficits observed in PD rat models via its antioxidative activities, maintaining the redox balance ( Xu et al, 2013 ). Similarly, asiaticoside has been found to reduce oxidative stress induced by rotenone ( Gopi and Arambakkam Janardhanam, 2017 ; Subaraja and Vanisree, 2019 ). Likewise, asiatic acid provided antioxidative benefits in a drosophila PD model, protecting mitochondria against rotenone-induced oxidative stress and apoptosis.…”