The novel high molecular weight <i>Dermatophagoides farinae</i> protein Zen‐1 is a major allergen in North American and European mite allergic dogs with atopic dermatitis

Olivry, Thierry; Dunston, Stanley M.; Favrot, Claude; Prélaud, Pascal; Tsukui, Toshihiro

doi:10.1111/vde.12393

Cited by 18 publications

(42 citation statements)

References 27 publications

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“…Given that no commercially available Der f 2 test exists, it is important to assess whether Der f 2 immunotherapy may be helpful in the treatment of Df sensitized dogs in the absence of this information. In one study, only 28% of European dogs showed positive IgE serology against Der f 2 . However, another study performed in Portugal and Spain challenged these findings and suggested that Der f 2 reactivity is prevalent, at least in Southern European atopic dogs .…”

Section: Discussionmentioning

confidence: 98%

“…Data on the prevalence of Der f 2 sensitization in Europe are conflicting and mainly suggest a low prevalence . Because Allermmune ® has thus far only been tested in Japanese dogs and dogs experimentally sensitized to Der f 2, the goal of this study was to evaluate the short‐term efficacy of Allermmune ® in atopic European dogs showing positive test reactions to Dermatophagoides farinae (Df).…”

Section: Introductionmentioning

confidence: 99%

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An open study on the efficacy of a recombinant Der f 2 (Dermatophagoides farinae) immunotherapy in atopic dogs in Hungary and Switzerland

Fischer

Tarpataki

Leidi³

et al. 2018

Veterinary Dermatology

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

An open study on the efficacy of a recombinant Der f 2 (Dermatophagoides farinae) immunotherapy in atopic dogs in Hungary and Switzerland

Fischer

Tarpataki

Leidi³

et al. 2018

Veterinary Dermatology

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“…These difering results prompted further European studies and, very recently, the presence of anti-Der f 1, Der f 2, Der f 15 and Der f 18-speciic IgE was detected in the serum of 18 Spanish atopic dogs sensitised to DF, resulting in the revised view that both low and high MW allergens are important in continental Europe. 15 To further concur with the Japanese group's indings, Olivry et al 16 concluded that Zen 1 was also a major allergen in North American and European atopic dogs sensitised to house dust mites. The reasons for the diferences between the various studies over time are unclear and many factors may play a role, not least the diferent methods of allergen/antibody detection and identiication used in the various studies.…”

Section: Introductionmentioning

confidence: 85%

Incidence of anti‐Der f 2 and anti‐Zen 1‐specific immunoglobulin E antibodies in atopic dogs from South‐East England

Patel¹,

Curtis²,

Cerundolo³

2019

Veterinary Record

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Recent studies from North America and continental Europe have reported Zen 1 as a major allergen in atopic dogs, and Der f 2 as a minor allergen. In contrast, Der f 2 is considered a major allergen in Japan. In this study, allergen-specific IgE against Der f 2, Zen 1 and crude Dermatophagoides farinae (DF) was determined using ELISA assays in English atopic dogs. Serum samples were obtained from 59 dogs with non-seasonal atopic dermatitis. ELISA assays using horseradish peroxidase-labelled anti-dog IgE monoclonal antibody (Bethyl; A40-125P) and recombinant Der f 2 (Zenoaq), natural Zen 1 (Zenoaq) and DF extract (Greer Laboratories; North Carolina) were performed by Zenoaq, Fukushima, Japan. The mean optical density (OD) of each sample was determined and the cut-off value was calculated from OD readings obtained from four healthy control dogs. Der f 2, Zen 1 and DF-specific IgE antibodies were found in the serum samples taken from 57 (97 per cent), 45 (76 per cent) and 47 (80 per cent) atopic dogs, respectively, suggesting that both Zen 1 and Der f 2 are ‘major allergens’ in the South-East England.

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“…This finding may be explained by the fact that there could be different routes of sensitization in atopic dermatitis and respiratory allergy but also by a more polyclonal response in patients with atopic dermatitis which includes otherwise more rarely recognized allergens. Allergic dogs which mainly show atopic dermatitis as the most relevant allergic manifestation also mount IgE-reactivity preferentially to house dust mite body-derived allergens [38] but not to allergens which are associated with airborne feces. This would indicate that the body-derived allergen indeed may sensitize via the skin.…”

Section: Allergen Molecules To Study Atopic Dermatitis Pathomechanismsmentioning

confidence: 99%

Molecular aspects of allergens in atopic dermatitis

Campana

Dzoro

Mittermann

et al. 2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewMolecular allergology uses pure, mainly recombinant and structurally defined allergen molecules and allergen-derived epitopes to study mechanisms of IgE-associated allergy, to diagnose, and even predict the development of allergic manifestations and to treat and prevent IgE-associated allergies. Atopic dermatitis, a chronic inflammatory skin disease is almost always associated with IgE sensitization to allergens. However, also non-IgE-mediated pathomechanisms seem to be operative in atopic dermatitis and it is often difficult to identify the disease-causing allergens. Here we review recent work showing the usefulness of molecular allergology to study mechanisms of atopic dermatitis, for diagnosis and eventually for treatment and prevention of atopic dermatitis.Recent findingsIgE sensitization to airborne, food-derived, microbial allergens, and autoallergens has been found to be associated with atopic dermatitis. Using defined allergen molecules and non-IgE-reactive allergen derivatives, evidence could be provided for the existence of IgE- and non-IgE-mediated mechanisms of inflammation in atopic dermatitis. Furthermore, effects of epicutaneous allergen administration on systemic allergen-specific immune responses have been studied. Multi-allergen tests containing micro-arrayed allergen molecules have been shown to be useful for the identification of culprit allergens in atopic dermatitis and may improve the management of atopic dermatitis by allergen-specific immunotherapy, allergen avoidance, and IgE-targeting therapies in a personalized medicine approach.SummaryMolecular allergology allows for dissection of the pathomechanisms of atopic dermatitis, provides new forms of allergy diagnosis for identification of disease-causing allergens, and opens the door to new forms of management by allergen-specific and T cells-targeting or IgE-targeting interventions in a personalized medicine approach.

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The novel high molecular weight Dermatophagoides farinae protein Zen‐1 is a major allergen in North American and European mite allergic dogs with atopic dermatitis

Abstract: This study establishes Zen-1 as a major allergen in atopic dogs sensitized to Df.

Cited by 18 publications

References 27 publications

An open study on the efficacy of a recombinant Der f 2 (Dermatophagoides farinae) immunotherapy in atopic dogs in Hungary and Switzerland

An open study on the efficacy of a recombinant Der f 2 (Dermatophagoides farinae) immunotherapy in atopic dogs in Hungary and Switzerland

Incidence of anti‐Der f 2 and anti‐Zen 1‐specific immunoglobulin E antibodies in atopic dogs from South‐East England

Molecular aspects of allergens in atopic dermatitis

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