The novel diagnostic marker in low-LVEF heart failure patients

Demir, Şerafettin; Ede, Hüseyin; Kaplan, Mehmet; Yavuz, Fethi; Yücel, Celal; Kurt, Ibrahim Halil

doi:10.4149/bll_2018_076

Cited by 6 publications

(6 citation statements)

References 13 publications

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“…PICP, a product in the metabolism of collagen type 1, was proven useful for the diagnosis and prognosis of heart failure and is associated with GLS values in patients with diabetes [28,29]. Moreover, on endomyocardial biopsy, PICP indicates the presence of collagen type I, adding to the hypothesis that this molecule can serve as a biomarker of cardiac fibrosis [30].…”

Section: Discussionmentioning

confidence: 99%

Connection between Cardiac Fibrosis Biomarkers and Echocardiography Parameters in Advanced Chronic Kidney Disease Patients

Ureche

Dodi

Covic

et al. 2023

JCM

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Background: Myocardial fibrosis represents a mainstay pathway in the pathophysiology of uremic cardiomyopathy. This process leads to structural and functional changes in the heart, which can be detected by echocardiography. The purpose of our study was to determine the association between four echocardiographic parameters (ejection fraction (EF), global longitudinal strain (GLS), mean E/e’ ratio, and left atrial volume indexed) and biomarkers associated with cardiac fibrosis, such as procollagen type I carboxy-terminal propeptide (PICP), procollagen type III N-terminal peptide (P3NP), and galectin-3 (Gal-3) in patients with end-stage renal disease (ESRD). Methods: 140 patients with ESRD were enrolled and investigated by echocardiography and the serum levels of the aforementioned biomarkers were determined at baseline. Results: The mean EF was 53.63 ± 8%, the mean GLS was −10.2 ± 5.3%, the mean E/e’ ratio was 9.8 ± 4.3, and the mean left atrial volume indexed (LAVI) was 45.8 ± 14.2 mL/m2. The average levels for PICP, P3NP, and Gal-3 were 457.2 ± 240 µg/L, 242 ± 199.9 µg/L, and 10.7 ± 3.7 ng/mL, respectively. In regression analysis, PICP was strongly associated with all four echocardiographic parameters (EF: p = 0.0002, R2 = 0.69; GLS: p = 0.00001, R2 = 0.81; mean E/e’: p = 0.00002; R2 = 0.89; LAVI: p = 0.003; R2 = 0.73). P3NP and Gal-3 were only associated with the EF (p = 0.01, R2 = 0.31 and p = 0.02; R2 = 0.35, respectively). Conclusion: Our study evidenced that PICP, a collagen-derived biomarker, is associated with important echocardiography parameters, suggesting that it can serve as an indicator of the presence of subclinical systolic and diastolic dysfunction in patients with advanced CKD.

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Section: Discussionmentioning

confidence: 99%

Connection between Cardiac Fibrosis Biomarkers and Echocardiography Parameters in Advanced Chronic Kidney Disease Patients

Ureche

Dodi

Covic

et al. 2023

JCM

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“…We also have documented the BNP is associated with anxiety in heart failure patients and the LVEF was significantly and negatively related with HAM-A 14 score. As important reflectors of cardiac function, NYHA classification, BNP and LVEF are widely used factors in predicting the existence and severity of heart failure [ 33 – 35 ]. It was relatively easy to conceive that the anxiety status would significantly increase as the symptoms of heart failure were getting worse.…”

Section: Discussionmentioning

confidence: 99%

Neutrophilic granulocyte percentage is associated with anxiety in Chinese hospitalized heart failure patients

Zhang

Yao

et al. 2022

BMC Cardiovasc Disord

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Background In patients with heart failure, anxiety disorder is common and associated with adverse prognosis. This study intended to find more confounding factors of Chinese heart failure patients. Methods We enrolled 284 hospitalized heart failure patients, whose New York Heart Association (NYHA) classed as II-IV and left ventricular ejection fraction (LVEF) ≤ 45%. All the patients were scaled in Hamilton Rating Scale for Anxiety (14-items) (HAM-A14). Ordinal logistic regression analysis was performed to examine the association of correlated factors with anxiety disorder. Results There were 184 patients had anxiety accounting for 64.8% of all 284 hospitalized heart failure patients. The neutrophilic granulocyte percentage, urea nitrogen, total bilirubin and brain natriuretic peptide were positively associated with HAM-A14 score, meanwhile, the hemoglobin, red blood cells counts, albumin and LVEF were negatively associated with HAM-A14 score (All P < 0.05). After the adjustments of sex, hemoglobin, urea nitrogen, total bilirubin, albumin and brain natriuretic peptide, the neutrophilic granulocyte percentage was significantly associated with anxiety (OR = 43.265, P = 0.012). The neutrophilic granulocyte percentage was 0.616 ± 0.111, 0.640 ± 0.102, 0.681 ± 0.106 and 0.683 ± 0.113 in heart failure patients with no anxiety, possible anxiety, confirmed anxiety and obvious anxiety, respectively. Conclusions Neutrophilic granulocyte percentage as well as the traditional risk factors such as sex, urea nitrogen and brain natriuretic peptide is associated with anxiety in hospitalized heart failure patients.

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“…Thirdly, complications, such as impaired renal function, may differentially infl uence the levels of both biomarkers (24). Consequently, the use of sNEP, simultaneously to NT-proBNP as a gold standard biomarker in HF and as a default comparator, when investigating novel biomarkers and therapies (28)(29)(30), may be of diagnostic advantage providing an additional valuable prognostic information for identifying diverse HF patient subpopulations. However, less sNEP in HFrEF sheds a new light on this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Altered serum levels of neprilysin in heart failure patients with reduced ejection fraction

Nemcekova¹,

Malikova²,

Gonçalvesová³

et al. 2021

BLL

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The novel diagnostic marker in low-LVEF heart failure patients

Abstract: PIP may not mirror acute events in follow-up of chronic heart failure but it is a very beneficial biomarker in diagnosis of low-LVEF heart failure with high sensitivity and specificity (Tab. 2, Fig. 1, Ref. 16).

Cited by 6 publications

References 13 publications

Connection between Cardiac Fibrosis Biomarkers and Echocardiography Parameters in Advanced Chronic Kidney Disease Patients

Connection between Cardiac Fibrosis Biomarkers and Echocardiography Parameters in Advanced Chronic Kidney Disease Patients

Neutrophilic granulocyte percentage is associated with anxiety in Chinese hospitalized heart failure patients

Altered serum levels of neprilysin in heart failure patients with reduced ejection fraction

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