The novel Chinese coronavirus (2019‐nCoV) infections: Challenges for fighting the storm

2019 novel coronavirus (2019-nCoV) outbreak: A new challenge

“…Furthermore, the risk of acute respiratory distress syndrome, with or without specific bacterial superinfection, has complicated the clinical course of up to 29% of patients (12) The first wave of 2019-CoV has caused 1775 deaths, despite the severity of illness was mild in most of the cases [1, 4-9, 12, 14-15]. Wang and colleagues [19] have interestingly reviewed underlying diseases, and demographic characteristics of deaths occurred in the Wuhan epidemic and have found that older adults (>70-years-old) have presented a shorter period between first symptom and death [11.5 (range 6-19) days Vs. 20 (range 10-41); P=0.033] as compared to younger persons, as previously reported for other beta-coronavirus [17][18]: this confirms the increased severity in the elderly for CoV illness [1,[4][5][6][7][8][9][10][11][12][13][14][15]. Furthermore, according to Wang and colleagues [19], 2019-CoV has developed a median period between symptomatic phase to death (median days 14) somewhat J o u r n a l P r e -p r o o f similar to MERS-CoV (median days 14) and SARS-CoV (median days 17.4) of MERS [12,[17][18] ( Table 2).…”

“…Leukopenia was the most common abnormality [1,[4][5][6][7][8][9], reported in up to 63% of subjects in Huang et al study [1]. Thrombocytopenia occurred in the reports by Holshue and Chen [4,10], but it is rarely J o u r n a l P r e -p r o o f reported in other series [1,[5][6][7][8][9][10][11][12][13][14][15], although low platelets counts were found in up to 45% of SARS-CoV and MERS-CoV infections [17][18]. Nevertheless, abnormalities in hepatic (e.g., slightly increase in AST and ALT levels) and muscle enzymes (e.g., slightly increase in creatine-kinase or lactate-dehydrogenase) were seen in early cases and later reported (Table 1) [1,[4][5][6][7][8][9][10][11][12][13][14][15].…”

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

“…Initial reports identified two species of snakes that could be a possible reservoir of the COVID-19. However, to date, there has been no consistent evidence of coronavirus reservoirs other than mammals and birds [10,18]. Genomic sequence analysis of COVID-19 showed 88% identity with two bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses [19,20], indicating that mammals are the most likely link between COVID-19 and humans.…”

“…As of January 30, 2020, 7734 cases have been confirmed in China and 90 other cases have also been reported from a number of countries that include Taiwan, Thailand, Vietnam, Malaysia, Nepal, Sri Lanka, Cambodia, Japan, Singapore, Republic of Korea, United Arab Emirates, United States, The Philippines, India, Australia, Canada, Finland, France, and Germany. The case fatality rate was calculated to be 2.2% (170/7824) [10]. The first case of COVID-19 infection confirmed in the United States led to the https://doi.org/10.1016/j.jaut.2020.102433 Received 10 February 2020; Received in revised form 17 February 2020; Accepted 18 February 2020 description, identification, diagnosis, clinical course, and management of this case.…”

Corona Virus International Public Health Emergencies: Implications for Radiology Management

“…Thus, 2019-nCoV has created enormous challenges for medical institutions in China (2). This article discusses how radiology departments can most effectively respond to this public health emergency.…”