The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of l-ascorbic acid: Synthesis, cytostatic, and antiviral activity evaluations

Synthesis and structural studies of C-5 aryl- and C-6 alkyl-substituted pyrimidine derivatives

“…Moreover, NOE between 2 0 -OH and 2-OCH 3 proved that 2-OCH 3 protons are more deshielded than 4-OCH 3 . The chemical shifts pattern of C-5 and C-6 disubstituted pyrimidine derivatives in 13 C NMR spectra are consistent with those observed for related compounds [7][8][9][10]18]. Moreover, the magnitudes of one-, two-, three-and fourbond C-F couplings in 7 at C-6 0 , C-5 0 , C-4 0 and C-3 0 , respectively, are in accord once with the literature data for fluorinated pyrimidine derivatives [7][8][9][10].…”

Synthesis, X-ray crystal structure study and antitumoral evaluations of 5,6-disubstituted pyrimidine derivatives

“…20 Recently, we have reported that some C-5 and/or C-6 substituted pyrimidine derivatives exhibited antiviral and cytostatic activities. [21][22][23][24] Syntheses and biological evaluations of C-6 alkylated pyrimidines as model compounds for development of tracer molecules in PET have been also reported. 25,26 Thus, we found that pyrimidine derivatives containing 2,3-dihydroxypropyl and 1,3-dihydroxyisobutyl side chain can be efficiently phosphorylated by HSV-1 TK and thus fulfill the necessary requirements for in vivo imaging of the HSV-1 TK gene expression.…”

Crystal structure of 5-iodo-1-tosylpyrimidine-2,4(1H,3H)-dione, C11H9IN2O4S

“…Uracil and its derivatives exhibit a broad spectrum of activity, and have been used as antitumor, antibacterial, and antiviral drugs [1][2][3]. For example, 5-fluorouracil was known one of the anticancer agents used clinically for the treatment of stomach, colorectal, and neck cancers [4,5].…”