The novel boric acid modified material as micro separation plant for 1,3-BDO: Adsorption behavior and mechanism

Jiang, Long; Liu, Yaojie; Zheng, Kexin; Zhang, Qun; Yu, Zongjiang; Xian, Ming; Xu, Chao

doi:10.1016/j.seppur.2022.122376

Cited by 4 publications

(1 citation statement)

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“…Tryptophan, an essential amino acid for both humans and animals, is extensively used as a supplement in the food and feed industries and as a medicine to improve sleep quality and mood [1]. The rising demand for tryptophan has significantly expanded its global market, driving research and development efforts on upstream and downstream processes for its industrial production, particularly through microbial fermentation [2,3,4,5]. The conventional downstream process for tryptophan involves complex separation technologies including centrifugation, membrane filtration, adsorption, and crystallization [6].…”

Section: Introductionmentioning

confidence: 99%

A Scale-Up of Fluidized Bed Granulation Process for Calcium-Tryptophan

Han,

Sung,

Kim

et al. 2024

Preprint

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The importance of tryptophan in both human and animal nutrition continues to drive its demand and market growth. The fluidized bed granulation is one of the crucial processes for industrial production of tryptophan from microbial fermentation, particularly as the simplified process of evaporation and granulation to efficiently generate commercial granular products. In this study, solid flow analysis for scaling up fluidized bed granulators in the manufacturing of calcium-tryptophan granules was conducted in terms of solid flow characteristics of the granules, flow regime within the granulator, and design considerations of the granulator. Based on the established scale-up case of calcium-tryptophan granules, it was founded that the flow regime of bubbling fluidization occurred similarly in both pilot and plant scale fluidized bed granulator. Then, the desired height (transport disengaging height, TDH) and entrainment rate (to secure the capacity of entrained particle recovery equipment such as cyclones or bag filters) were determined to obtain basic design data for scale-up of the fluidized bed granulation.

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