The Nottingham Fatigue after Stroke (NotFAST) study: factors associated with severity of fatigue in stroke patients without depression

Drummond, Avril; Hawkins, Loiuse; Sprigg, Nikola; Ward, Nick; Mistri, Amit; Tyrrell, Pippa; Mead, Gillian; Worthington, Esme; Lincoln, Nadina B.

doi:10.1177/0269215517695857

Cited by 32 publications

(29 citation statements)

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“…Three cross-sectional surveys were embedded within cohort studies 91 , 94 , 97 . Only one of the studies (NotFAST) had a follow-up report 81 – 85 . Details of all studies are reported in Table 3 as well as the Extended data .…”

Section: Resultsmentioning

confidence: 99%

Post-stroke fatigue: a scoping review

et al. 2020

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Background: Post-stroke fatigue (PSF) is one of the most common and frustrating outcomes of stroke. It has a high prevalence and it can persist for many years after stroke. PSF itself contributes to a wider range of undesirable outcomes that affect all aspects of daily life. The aim of this review was to identify and summarise the most recent research on PSF, in order to update the evidence base. Methods: We updated an existing review (Hinkle et al. 2017) systematically searching CINAHL, MEDLINE, PsycINFO, and PubMed to cover new research studies between 1st March 2016 and the search date (19th January 2020). We included interventional and observational research, and clinical practice guidelines that were not covered in the original review. After duplicate removal in EndNote, two reviewers screened the search results in Rayyan, and data from eligible full texts were extracted onto an Excel spreadsheet. Finally, we used RobotReviewer and a human reviewer to assess the risk of bias of randomised trials for this scoping review. Results: We identified 45 records for 30 studies (14 observational, 10 interventional studies, and 6 guidelines). Apart from one, the interventional studies were single-centred, had high risk of bias and small sample size (median 50). They investigated exercise, pharmacotherapy, psychotherapy, education, and light therapy. Observational studies mainly reported the factors related to PSF including co-morbidities, depression and anxiety, quality of life, activities of daily living, stroke severity, medication use and polypharmacy, polymorphism, pain, apathy, limb heaviness, neuroticism, mobility, and thyroid-stimulating hormone. Guidelines either did not report on PSF or, when reported, their recommendations were supported by little or low level of evidence. Conclusion: Although we identified a number of recent studies which have added to our current knowledge on PSF, none are robust enough to change current clinical practice.

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Section: Resultsmentioning

confidence: 99%

Post-stroke fatigue: a scoping review

et al. 2020

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“…In our previous study, we investigated the factors affecting fatigue at four to six weeks following stroke onset (n=268); these results have been reported in detail elsewhere (9). In summary, 115 (43%) participants reported fatigue, of whom 71 (62%) identified this as a post-stroke symptom.…”

Section: Introductionmentioning

confidence: 87%

“…NotFAST was a multi-centre, longitudinal cohort study; the methodology has been reported previously (9). Participants were recruited from four UK inpatient stroke services Participants were ineligible if they were unable to read or speak English sufficient to complete questionnaires or had a documented diagnosis of dementia.…”

Section: Methodsmentioning

confidence: 99%

The Nottingham Fatigue After Stroke (NotFAST) study: results from follow-up six months after stroke

Hawkins

Lincoln

Sprigg

et al. 2017

Topics in Stroke Rehabilitation

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Background Post-stroke fatigue is common and disabling. Objectives The aim of NotFAST was to examine factors associated with fatigue in stroke survivors without depression, six months after stroke. Methods Participants were recruited from four UK stroke units. Those with high levels of depressive symptoms (score ≥7 on Brief Assessment Schedule Depression Cards) or aphasia were excluded. Follow-up assessment was conducted at six months after stroke. They were assessed on the Fatigue Severity Scale, Rivermead Mobility Index, Nottingham Extended Activities of Daily Living scale, Barthel Index, Beck Anxiety Index, Brief Assessment Schedule Depression Cards, Impact of Event Scale-Revised, and Sleep Hygiene Index. Results Of the 371 participants recruited, 263 (71%) were contacted at six months after stroke and 213 (57%) returned questionnaires. Approximately half (n = 109, 51%) reported fatigue at six months. Of those reporting fatigue initially (n = 88), 61 (69%) continued to report fatigue. 'De novo' (new) fatigue was reported by 48 (38%) of those not fatigued initially. Lower Nottingham Extended Activities of Daily Living scores and higher Beck Anxiety Index scores were independently associated with fatigue at six months. Conclusions Half the stroke survivors reported fatigue at six months post-stroke. Reduced independence in activities of daily living and higher anxiety levels were associated with the level of fatigue. Persistent and delayed onset fatigue may affect independence and participation in rehabilitation, and these findings should be used to inform the development of appropriate interventions.

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“…Potential interviewees were identified from participants in the NotFAST study (Drummond et al, 2017). This was a multi-centre longitudinal cohort study to investigate post-stroke fatigue and its associated factors in patients who did not have high levels of depressive symptoms or aphasia.…”

Section: Designmentioning

confidence: 99%

“…The aim of the present study was to explore the day-to-day fatigue-related experiences and perspectives of participants who reported high levels of fatigue at six months following stroke in the Nottingham Fatigue After Stroke (NotFAST) study (Drummond et al, 2017).…”

Section: Introductionmentioning

confidence: 99%