The Nose Knows: Intranasal Midazolam To Treat Acute Seizures During Inpatient Epilepsy Monitoring

Vossler, David G.

doi:10.1177/1535759720955167

Cited by 1 publication

(1 citation statement)

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“…In both, the RCTs’ treatment success consisted of two components: First is the seizure termination, and second, there was no seizure remission for up to six hours. Presently, we could not find the categorized percentage of effectiveness of MDZ-NS in different kinds of seizures, but studies by Vossler [ 24 ] and Brigo et al [ 25 ] suggested that midazolam is effective in all kinds of seizures [ 24 , 25 ]. Also, the time to the first seizure following treatment is longer with midazolam nasal spray than with a placebo.…”

Section: Reviewmentioning

confidence: 98%

The Evaluation of the Efficacy and Safety of Midazolam Nasal Spray in Patients With Seizure Clusters: A Systematic Review and Meta-Analysis

Niraj¹,

Mahajan²,

Prakash³

et al. 2023

Cureus

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Midazolam nasal spray (MDZ-NS) is a new emerging rescue medication that suppresses epileptic seizures. Until now, few studies, pharmacokinetic (PK) and pharmacodynamic (PD) profiles, and clinical trials have shown that midazolam nasal spray could become an effective and promising alternative to conventional routes (intravenous {IV}/rectal). Therefore, we thought of conducting a systematic review and meta-analysis After the administration of MDZ-NS, either the patients remained seizure-free for six hours or more or the seizure was terminated within 10 minutes and had no recurrence between 10 minutes and six hours. The risk ratio (RR) obtained was 1.54 (95% CI: 1.25-1.91). The result was statistically significant as a higher success rate was observed with the use of 5 mg midazolam nasal spray compared to placebo (p < 0.0001).Heterogeneity was not observed in the results of the included studies (inconsistency index {I 2 }: 0%).The present systematic review and meta-analysis demonstrated that 5 mg midazolam nasal spray was efficacious in treating patients with seizure clusters and is well-tolerated. Also, its use is relatively safe.

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