In this chapter, we contend that the EU suffers from a self-harming border disorder. The discriminatory border regime, which we dissect in a pre-border visa regime, the in-situ land and sea borders, and the post-border camps, has led to a recurrent demarcation of increasingly inhumane, unlawful, and deadlier borders, which is strongly at odds with the own humanist values and rule of law that the EU is supposed to uphold. So, the core of the border complexity that we expose lies in this irony: in the attempt to protect, via its border regime, what it considers its essence, the EU has triggered an autoimmune disorder that has turned that same border regime into the Union's most formidable threat.